Patents by Inventor Marshall Grant

Marshall Grant has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating hypoglycemia events in diabetes treatment
    Patent number: 11980656
    Abstract: An ultra-rapid acting insulin composition and method for treating hyperglycemia in patients with diabetes are disclose. The composition is an inhalable dry powder composition comprising fumaryl diketopiperazine and insulin for pulmonary delivery, which significantly reduces the rates of hypoglycemic events in patients in patients on mealtime insulin therapy.
    Type: Grant
    Filed: August 3, 2021
    Date of Patent: May 14, 2024
    Assignee: MannKind Corporation
    Inventors: Marshall Grant, Simon R. Bruce, Robert A. Baughman
  • METHOD FOR IMPROVING THE PHARMACEUTIC PROPERTIES OF MICROPARTICLES COMPRISING DIKETOPIPERAZINE AND AN ACTIVE AGENT
    Publication number: 20230414500
    Abstract: Methods are provided for drying a particle. Specifically, there is provided a spray-dried diketopiperazine-insulin particle formulation having improved aerodynamic performance and in which the active agent is more stabile and efficiently delivered as compared to that of the lyophilized diketopiperazine-insulin formulation. The dry powders have utility as pharmaceutical formulations for pulmonary delivery.
    Type: Application
    Filed: September 12, 2023
    Publication date: December 28, 2023
    Inventors: Bryan R. Wilson, Marshall Grant
  • HIGH CAPACITY DIKETOPIPERAZINE MICROPARTICLES AND METHODS
    Publication number: 20230016875
    Abstract: Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine microparticle are formed using fumaryl diketopiperazine and can comprise a drug in large doses for the treatment of disease or disorders by pulmonary delivery via oral inhalation.
    Type: Application
    Filed: July 26, 2022
    Publication date: January 19, 2023
    Applicant: MannKind Corporation
    Inventors: Marshall Grant, Paul Menkin, Grayson W. Stowell
  • High capacity diketopiperazine microparticles and methods
    Patent number: 11433135
    Abstract: Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine microparticle are formed using fumaryl diketopiperazine and can comprise a drug in large doses for the treatment of disease or disorders by pulmonary delivery via oral inhalation.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: September 6, 2022
    Assignee: MannKind Corporation
    Inventors: Marshall Grant, Paul Menkin, Grayson W. Stowell
  • COMPOSITION AND METHOD FOR REDUCING HYPOGLYCEMIA EVENTS IN DIABETES TREATMENT
    Publication number: 20210361746
    Abstract: An ultra-rapid acting insulin composition and method for treating hyperglycemia in patients with diabetes are disclose. The composition is an inhalable dry powder composition comprising fumaryl diketopiperazine and insulin for pulmonary delivery, which significantly reduces the rates of hypoglycemic events in patients in patients on mealtime insulin therapy.
    Type: Application
    Filed: August 3, 2021
    Publication date: November 25, 2021
    Applicant: MannKind Corporation
    Inventors: Marshall Grant, Simon R. Bruce, Robert A. Baughman
  • Composition and method for reducing hypoglycemia events in diabetes treatment
    Patent number: 11110151
    Abstract: An ultra-rapid acting insulin composition and method for treating hyperglycemia in patients with diabetes are disclose. The composition is an inhalable dry powder composition comprising fumaryl diketopiperazine and insulin for pulmonary delivery, which significantly reduces the rates of hypoglycemic events in patients in patients on mealtime insulin therapy.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: September 7, 2021
    Assignee: MannKind Corporation
    Inventors: Marshall Grant, Simon R. Bruce, Robert A. Baughman
  • METHOD AND COMPOSITION FOR TREATING OBESITY
    Publication number: 20210259963
    Abstract: A method for treating obesity associated to Prader Willi Syndrome and/or binge eating is disclosed. The method utilizes a rapid drug delivery system which delivers small molecules and peptides to the lungs by oral inhalation.
    Type: Application
    Filed: April 25, 2019
    Publication date: August 26, 2021
    Applicant: MannKind Corporation
    Inventors: Michael CASTAGNA, David KENDALL, Kelly KRAFT, Chad C. SMUTNEY, Marshall GRANT
  • METHOD AND COMPOSITION FOR ADMINISTERING PROSTAGLANDINS
    Publication number: 20200405731
    Abstract: A method for treating migraines is disclosed. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent, including small molecules and peptides being administered to a patient in need of treatment. In particular, the drug delivery system is designed for inhalation for delivery of drugs to the pulmonary circulation in a rapid and therapeutically effective manner.
    Type: Application
    Filed: September 9, 2020
    Publication date: December 31, 2020
    Inventors: Joseph J. Guarneri, Marshall Grant, Chad C. Smutney, John J. Freeman, JR., Nikhil Amin, Kelly S. Kraft, Andrea Leone-Bay
  • HIGH CAPACITY DIKETOPIPERAZINE MICROPARTICLES AND METHODS
    Publication number: 20200147221
    Abstract: Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine microparticle are formed using fumaryl diketopiperazine and can comprise a drug in large doses for the treatment of disease or disorders by pulmonary delivery via oral inhalation.
    Type: Application
    Filed: January 10, 2020
    Publication date: May 14, 2020
    Applicant: MannKind Corporation
    Inventors: Marshall Grant, Paul Menkin, Grayson W. Stowell
  • High capacity diketopiperazine microparticles and methods
    Patent number: 10603383
    Abstract: Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine microparticle are formed using fumaryl diketopiperazine and can comprise a drug in large doses for the treatment of disease or disorders by pulmonary delivery via oral inhalation.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: March 31, 2020
    Assignee: MannKind Corporation
    Inventors: Marshall Grant, Paul Menkin, Grayson W. Stowell
  • COMPOSITION AND METHOD FOR REDUCING HYPOGLYCEMIA EVENTS IN DIABETES TREATMENT
    Publication number: 20190365866
    Abstract: An ultra-rapid acting insulin composition and method for treating hyperglycemia in patients with diabetes are disclose. The composition is an inhalable dry powder composition comprising fumaryl diketopiperazine and insulin for pulmonary delivery, which significantly reduces the rates of hypoglycemic events in patients in patients on mealtime insulin therapy.
    Type: Application
    Filed: June 21, 2019
    Publication date: December 5, 2019
    Applicant: MannKind Corporation
    Inventors: Marshall Grant, Simon R. Bruce, Robert A. Baughman
  • HIGH CAPACITY DIKETOPIPERAZINE MICROPARTICLES AND METHODS
    Publication number: 20190336606
    Abstract: Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine microparticle are formed using fumaryl diketopiperazine and can comprise a drug in large doses for the treatment of disease or disorders by pulmonary delivery via oral inhalation.
    Type: Application
    Filed: June 26, 2019
    Publication date: November 7, 2019
    Applicant: MannKind Corporation
    Inventors: Marshall Grant, Paul Menkin, Grayson W. Stowell
  • METHOD FOR IMPROVING THE PHARMACEUTIC PROPERTIES OF MICROPARTICLES COMPRISING DIKETOPIPERAZINE AND AN ACTIVE AGENT
    Publication number: 20190314276
    Abstract: Methods are provided for drying a particle. Specifically, there is provided a spray-dried diketopiperazine-insulin particle formulation having improved aerodynamic performance and in which the active agent is more stabile and efficiently delivered as compared to that of the lyophilized diketopiperazine-insulin formulation. The dry powders have utility as pharmaceutical formulations for pulmonary delivery.
    Type: Application
    Filed: June 26, 2019
    Publication date: October 17, 2019
    Inventors: Bryan R. Wilson, Marshall Grant
  • Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
    Patent number: 10376466
    Abstract: Methods are provided for drying a particle. Specifically, there is provided a spray-dried diketopiperazine-insulin particle formulation having improved aerodynamic performance and in which the active agent is more stabile and efficiently delivered as compared to that of the lyophilized diketopiperazine-insulin formulation. The dry powders have utility as pharmaceutical formulations for pulmonary delivery.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: August 13, 2019
    Assignee: MannKind Corporation
    Inventors: Bryan R. Wilson, Marshall Grant
  • High capacity diketopiperazine microparticles and methods
    Patent number: 10376587
    Abstract: Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine microparticle are formed using fumaryl diketopiperazine and can comprise a drug in large doses for the treatment of disease or disorders by pulmonary delivery via oral inhalation.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: August 13, 2019
    Assignee: MannKind Corporation
    Inventors: Marshall Grant, Paul Menkin, Grayson W. Stowell
  • HIGH CAPACITY DIKETOPIPERAZINE MICROPARTICLES AND METHODS
    Publication number: 20190076530
    Abstract: Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine microparticle are formed using fumaryl diketopiperazine and can comprise a drug in large doses for the treatment of disease or disorders by pulmonary delivery via oral inhalation.
    Type: Application
    Filed: October 4, 2018
    Publication date: March 14, 2019
    Inventors: Marshall Grant, Paul Menkin, Grayson W. Stowell
  • METHOD FOR IMPROVING THE PHARMACEUTIC PROPERTIES OF MICROPARTICLES COMPRISING DIKETOPIPERAZINE AND AN ACTIVE AGENT
    Publication number: 20190029954
    Abstract: Methods are provided for drying a particle. Specifically, there is provided a spray-dried diketopiperazine-insulin particle formulation having improved aerodynamic performance and in which the active agent is more stabile and efficiently delivered as compared to that of the lyophilized diketopiperazine-insulin formulation. The dry powders have utility as pharmaceutical formulations for pulmonary delivery.
    Type: Application
    Filed: October 4, 2018
    Publication date: January 31, 2019
    Inventors: Bryan R. Wilson, Marshall Grant
  • Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
    Patent number: 10130581
    Abstract: Methods are provided for drying a particle. Specifically, there is provided a spray-dried diketopiperazine-insulin particle formulation having improved aerodynamic performance and in which the active agent is more stabile and efficiently delivered as compared to that of the lyophilized diketopiperazine-insulin formulation. The dry powders have utility as pharmaceutical formulations for pulmonary delivery.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: November 20, 2018
    Assignee: MannKind Corporation
    Inventors: Bryan R. Wilson, Marshall Grant
  • High capacity diketopiperazine microparticles and methods
    Patent number: 10130709
    Abstract: Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine microparticle are formed using fumaryl diketopiperazine and can comprise a drug in large doses for the treatment of disease or disorders by pulmonary delivery via oral inhalation.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: November 20, 2018
    Assignee: MannKind Corporation
    Inventors: Marshall Grant, Paul Menkin, Grayson W. Stowell
  • METHOD AND COMPOSITION FOR TREATING MIGRAINES
    Publication number: 20170232001
    Abstract: A method for treating migraines is disclosed. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent, including small molecules and peptides being administered to a patient in need of treatment. In particular, the drug delivery system is designed for inhalation for delivery of drugs to the pulmonary circulation in a rapid and therapeutically effective manner.
    Type: Application
    Filed: February 28, 2017
    Publication date: August 17, 2017
    Inventors: Andrea Leone-Bay, Grayson W. Stowell, Joseph J. Guarneri, Dawn M. Carlson, Marshall Grant, Chad C. Smutney