Patents by Inventor Marta Filizola

Marta Filizola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SOX11 INHIBITORS FOR TREATING MANTLE CELL LYMPHOMA
    Publication number: 20230242496
    Abstract: Disclosed are compounds that are chemical inhibitors of SOX11. The compounds disclosed are useful in treatment of various cancers.
    Type: Application
    Filed: June 15, 2021
    Publication date: August 3, 2023
    Applicant: Icahn School of Medicine At Mount Sinai
    Inventors: Jian JIN, Marta FILIZOLA, Aneel AGGARWAL, Samir PAREKH, Abhijeet KAPOOR, Shashidhar S. JATIANI, H. Umit KANISKAN, Jianping HU, Yudao SHEN, Fanye MENG, Lihuai QIN, Yulin HAN, Xufen YU, Chengwei ZHANG, Prashasti KUMAR, Rinku JAIN, Clement LEE
  • Tetrahydronaphthyridinepentanamide integrin antagonists
    Patent number: 11192889
    Abstract: Tetrahydronaphthyridines of formula are disclosed. These compounds selectively inhibit ?V?3 without activating the ?V?3 receptor. They are useful for treating osteoporosis, acute myelogenous leukemia, sickle cell disease, focal segmental glomerulosclerosis, fibrosis, supravalvular aortic stenosis associated with Williams syndrome, tumors expressing ?V?3, tumor metastasis, bone resorption, T-cell lymphoma, retinal disease, age-related macular degeneration, diabetic retinitis, and herpes simplex virus infection. They may also be used for inhibiting tumor angiogenesis.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: December 7, 2021
    Assignee: THE ROCKEFELLER UNIVERSITY
    Inventors: Barry S. Coller, Marta Filizola, Michael Andrew Foley
  • TETRAHYDRONAPHTHYRIDINEPENTANAMIDE INTEGRIN ANTAGONISTS
    Publication number: 20200181138
    Abstract: Tetrahydronaphthyridines of formula are disclosed. These compounds selectively inhibit ?V?3 without activating the ?V?3 receptor. They are useful for treating osteoporosis, acute myelogenous leukemia, sickle cell disease, focal segmental glomerulosclerosis, fibrosis, supravalvular aortic stenosis associated with Williams syndrome, tumors expressing ?V?3, tumor metastasis, bone resorption, T-cell lymphoma, retinal disease, age-related macular degeneration, diabetic retinitis, and herpes simplex virus infection. They may also be used for inhibiting tumor angiogenesis.
    Type: Application
    Filed: July 5, 2017
    Publication date: June 11, 2020
    Applicants: The Rockefeller University, ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Barry S. COLLER, Marta FILIZOLA, Michael Andrew FOLEY
  • Kappa opioid receptor selective compounds, compositions, and uses thereof
    Patent number: 9868730
    Abstract: The present invention provides, inter alia, compounds of formula (I): (structurally represented). Also provided are pharmaceutical compositions containing such compounds and methods for treating or ameliorating the effects of a medical condition in a subject using such compounds or pharmaceutical compositions.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: January 16, 2018
    Assignees: The Trustees of Columbia University in the City of New York, Icahn School of Medicine at Mount Sinai
    Inventors: Jonathan Javitch, Marie-Laure Rives, Marta Filizola, Thomas E. Prisinzano
  • Oxadiazolo[3,2-A]pyrimidines and thiadiazolo[3,2-A]pyrimidines
    Patent number: 9532989
    Abstract: The present invention relates to compounds of Formula P-I where the variables (e.g. R1, Y, A, R1, Ra, Ra?, Rb, Rb?, Rc, Rc?, Rd, Rd?, Re, or Re?) and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The present invention further relates to methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: January 3, 2017
    Assignees: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, THE ROCKEFELLER UNIVERSITY
    Inventors: Barry S. Coller, Craig Thomas, Marta Filizola, Joshua McCoy, Wenwei Huang, Min Shen
  • 7-(piperazin-1-yl)-5H-[1,3,4]thiadiazolo[3,2-A]pyrimidin-5-ones for the treatment of thrombotic disorders
    Patent number: 9303044
    Abstract: The present invention relates to compounds and compositions of Formula P useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The definitions of variables A, B, R2, R3, R4, Ra, Ra?, Rb, Rb?, Rc, Rd, Rd?, Re, and Re? are provided in the disclosure. The present invention further relates to methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.
    Type: Grant
    Filed: January 16, 2013
    Date of Patent: April 5, 2016
    Assignees: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE ROCKEFELLER UNIVERSITY, ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Barry S. Coller, Craig Thomas, Marta Filizola, Joshua McCoy, Wenwei Huang, Min Shen, Jian-Kang Jiang
  • KAPPA OPIOID RECEPTOR SELECTIVE COMPOUNDS, COMPOSITIONS, AND USES THEREOF
    Publication number: 20160002216
    Abstract: The present invention provides, inter alia, compounds of formula (I): (structurally represented). Also provided are pharmaceutical compositions containing such compounds and methods for treating or ameliorating the effects of a medical condition in a subject using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: February 14, 2014
    Publication date: January 7, 2016
    Inventors: Jonathan JAVITCH, Marie-Laure RIVES, Marta FILIZOLA, Thomas E, PRISINZANO
  • ORGANIC COMPOUNDS
    Publication number: 20150374697
    Abstract: The present invention relates to compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The present invention further relates to methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.
    Type: Application
    Filed: June 4, 2015
    Publication date: December 31, 2015
    Inventors: Barry S. Coller, Craig Thomas, Marta Filizola, Joshua McCoy, Wenwei Huang, Min Shen
  • Oxadiazolo[3,2-a]pyrimidines and thiadiazolo[3,2-a]pyrimidines
    Patent number: 9066948
    Abstract: The present invention relates to compounds of formula P-1 and related compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The definitions of A, Y, R1, R2, Ra, Ra?, Rb, Rb?, Rc, Rc?, Rd, Rd?, Re, and Re? are provided herein. The present invention further relates to methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.
    Type: Grant
    Filed: July 15, 2011
    Date of Patent: June 30, 2015
    Assignees: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE ROCKEFELLER UNIVERSITY, ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Barry S. Coller, Craig Thomas, Marta Filizola, Joshua McCoy, Wenwei Huang, Min Shen
  • ORGANIC COMPOUNDS
    Publication number: 20150050325
    Abstract: The present invention relates to compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The present invention further relates to a drug-eluting stent comprising said compounds and methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.
    Type: Application
    Filed: January 16, 2013
    Publication date: February 19, 2015
    Applicant: The Rockefeller University
    Inventors: Barry S. Coller, Craig Thomas, Marta Filizola, Joshua McCoy, Wenwei Huang, Min Shen, Jian-Kang Jiang
  • ORGANIC COMPOUNDS
    Publication number: 20130251761
    Abstract: The present invention relates to compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The present invention further relates to methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.
    Type: Application
    Filed: July 15, 2011
    Publication date: September 26, 2013
    Inventors: Barry S. Coller, Craig Thomas, Marta Filizola, Joshua Mccoy, Wenwei Huang, Min Shen