Patents by Inventor Marta Marfil Sanchez

Marta Marfil Sanchez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INTERMEDIATES AND PROCESS FOR THE PREPARATION OF AROMATIC DERIVATIVES OF 1-ADAMANTANE
    Publication number: 20110040115
    Abstract: Process for the preparation of aromatic derivatives of 1-adamantane (tricyclo[3.3.1.1 (3,7)]decane), or an acceptable pharmaceutical salt thereof, based on a hydrolysis reaction of a precursor cyano compound. It also comprises different processes for obtaining the cyano compound. It is especially useful for obtaining Adapalene on an industrial scale in high yield and purity. It also comprises new intermediates useful in said preparation process.
    Type: Application
    Filed: December 1, 2006
    Publication date: February 17, 2011
    Applicant: FINORGA SAS
    Inventors: Alexander Christian Comely, Marta Marfil Sánchez, Llorenc Rafecas Jané, Antoni Riera Escalé
  • PROCESS FOR THE PREPARATION OF AROMATIC DERIVATIVES OF 1-ADAMANTANE
    Publication number: 20100010265
    Abstract: Process for the obtaining of 1-adamantane (tricycle[3.3.1.1 (3,7)]decane) derivatives, or of a pharmaceutically acceptable salt thereof, based on a carboxylation reaction, via metallation, of a precursor compound with an adequate leaving group. It also comprises the preparation of the precursor compound by means of a selective coupling of the corresponding boron, magnesium or zinc derivative with the corresponding disubstitute aromatic derivative. It is especially useful for the obtaining of Adapalene at industrial scale with good yield and high purity.
    Type: Application
    Filed: September 21, 2009
    Publication date: January 14, 2010
    Inventors: Alexander Christian Comely, Marta Marfil Sanchez, Llorenc Rafecas Jane, Xavier Verdaguer Espaulella
  • Process for the preparation of aromatic derivatives of 1-adamantane
    Patent number: 7645910
    Abstract: Process for the obtaining of 1-adamantane (tricycle[3.3.1.1 (3,7)]decane) derivatives, or of a pharmaceutically acceptable salt thereof, based on a carboxylation reaction, via metallation, of a precursor compound with an adequate leaving group. It also comprises the preparation of the precursor compound by means of a selective coupling of the corresponding boron, magnesium or zinc derivative with the corresponding disubstitute aromatic derivative. It is especially useful for the obtaining of Adapalene at industrial scale with good yield and high purity.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: January 12, 2010
    Assignee: Finorga SAS
    Inventors: Alexander Christian Comely, Marta Marfil Sánchez, Llorenç Rafecas Jané, Xavier Verdaguer Espaulella
  • PROCESS FOR THE PREPARATION OF AROMATIC DERIVATIVES OF 1-ADAMANTANE
    Publication number: 20090137841
    Abstract: Process for the obtaining of 1-adamantane (tricycle[3.3.1.1 (3,7)]decane) derivatives, or of a pharmaceutically acceptable salt thereof, based on a carboxylation reaction, via metallation, of a precursor compound with an adequate leaving group. It also comprises the preparation of the precursor compound by means of a selective coupling of the corresponding boron, magnesium or zinc derivative with the corresponding disubstitute aromatic derivative. It is especially useful for the obtaining of Adapalene at industrial scale with good yield and high purity.
    Type: Application
    Filed: December 1, 2006
    Publication date: May 28, 2009
    Inventors: Alexander Christian Comely, Marta Marfil Sanchez, Llorenc Rafecas Jane, Xavier Verdaguer Espaulella