Patents by Inventor Martha Karen Newell

Martha Karen Newell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for treating human proliferative diseases, with a combination of fatty acid metabolism inhibitors and glycolytic inhibitors
    Patent number: 7445794
    Abstract: The present invention generally relates to systems and methods for treating inflammatory and proliferative diseases, and wounds, using a combination of (1) fatty acid metabolism inhibitors and (2) glycolytic inhibitors and/or UCP and/or Fas inhibitors or antibodies. More particularly, the invention combines an oxirane carboxylic acid compound, represented by etomoxir, with a 2-deoxyglucose compound, represented by 2-deoxy-D-glucose, and/or an antibody against UCP and/or Fas antigen. The systems and methods of the invention can be used to treat drug-resistant or multi-drug resistant cancers (i.e., cancers resistant to conventional cancer drug therapies).
    Type: Grant
    Filed: April 28, 2005
    Date of Patent: November 4, 2008
    Assignee: The Regents of the University of Colorado
    Inventors: Martha Karen Newell, Elizabeth Villobos-Menuey, Evan Newell
  • Methods and products related to metabolic interactions in disease
    Publication number: 20080182329
    Abstract: The invention involves methods of regulating cell growth and division to control disease processes by manipulating mitochondrial metabolism and the expression of cell surface immune proteins. The invention also involves related compositions and screening assays.
    Type: Application
    Filed: August 17, 2007
    Publication date: July 31, 2008
    Applicant: University of Vermont and State Agricultural College
    Inventor: Martha Karen Newell
  • Methods and products related to metabolic interactions in disease
    Publication number: 20080181864
    Abstract: The invention involves methods of regulating cell growth and division to control disease processes by manipulating mitochondrial metabolism and the expression of cell surface immune proteins. The invention also involves related compositions and screening assays.
    Type: Application
    Filed: August 20, 2007
    Publication date: July 31, 2008
    Applicant: University of Vermont and State Agricultural College
    Inventor: Martha Karen Newell
  • Methods and products related to metabolic interactions in disease
    Patent number: 7390782
    Abstract: The invention involves methods of regulating cell growth and division to control disease processes by manipulating mitochondrial metabolism and the expression of cell surface immune proteins. The invention also involves related compositions and screening assays.
    Type: Grant
    Filed: March 17, 2004
    Date of Patent: June 24, 2008
    Assignee: University of Vermont and State Agricultural College
    Inventor: Martha Karen Newell
  • Methods and products related to metabolic interactions in disease
    Patent number: 7381413
    Abstract: The invention involves methods of regulating cell growth and division to control disease processes by manipulating mitochondrial metabolism and the expression of cell surface immune proteins. The invention also involves related compositions and screening assays.
    Type: Grant
    Filed: March 27, 1999
    Date of Patent: June 3, 2008
    Assignee: University of Vermont and State Agricultural College
    Inventor: Martha Karen Newell
  • Diagnostic and Therapeutic Treatments Related to Mitochondrial Disorders
    Publication number: 20080057039
    Abstract: Abstract: The invention is based in part on the discovery that chromosomal disorders such as Down Syndrome can be diagnosed by assessing maternal mitochondrial status. Thus the invention relates to diagnostic and therapeutic methods and related products for chromosomal disorders such as Downs Syndrome, for example, for identifying a risk of fetal Downs syndrome and methods of mitigating that risk. The methods also re useful for other therapies where it is desirable to manipulate mitochondria such as tissue generation.
    Type: Application
    Filed: May 12, 2004
    Publication date: March 6, 2008
    Inventors: Martha Karen Newell Rogers, Elizabeth Villalobos-Menuey, Robert Melamede, Robert Camley
  • Methods for regulating co-stimulatory molecule expression with reactive oxygen
    Publication number: 20040005291
    Abstract: The invention is based in part on the discovery that the expression of co-stimulatory molecules such as B7.1, B7.2 or CD40 can be regulated using reactive oxygen species (ROS). Thus, the invention relates to methods of regulating co-stimulatory molecules by modulating reactive oxygen. The methods and products are useful, for example, for modulating antigen specific immune responses, treating disease, and for modulating cell growth.
    Type: Application
    Filed: October 15, 2002
    Publication date: January 8, 2004
    Inventors: Martha Karen Newell Rogers, Robert Camley, Charles Richard Ill, Thomas Christensen, Zbigniew Celinski, Richard Trauger, Evan Newell, Elizabeth Villalobos-Menuey