Patents by Inventor Martha S. Petrovick
Martha S. Petrovick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230287487Abstract: The disclosure provides various systems and methods for identifying individuals from one or more samples. In particular, improved systems and methods of analysis are provided for handling multiple contributors, as well as systems and methods that model not only individual error rates per locus but factor in amplification of errors induced through PCR cycles. In some embodiments, modeling of error rates can be applied in multi-contributor settings to more accurately establish real alleles from artifacts. Other aspects involve application of sequencing in error modeling. Further, methods are provided for determining the presence of common individual DNA profiles in one or more complex DNA mixtures and for deconvolution of multiple complex DNA mixtures into shared individual components. The methods of the disclosure do not require any prior knowledge of individual DNA profiles or contributors to the complex DNA mixtures.Type: ApplicationFiled: February 1, 2023Publication date: September 14, 2023Applicant: Massachusetts Institute of Technology.Inventors: Darrell Orlyn Ricke, James Harper, Brian S. Helfer, Joseph Isaacson, Adam M. Michaleas, Martha S. Petrovick, Eric Schwoebel, Anna Shcherbina, Philip Fremont-Smith, James G Watkins, Edward C. Wack
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Patent number: 11655498Abstract: The disclosure provides various systems and methods for identifying individuals from one or more samples. In particular, improved systems and methods of analysis are provided for handling multiple contributors, as well as systems and methods that model not only individual error rates per locus but factor in amplification of errors induced through PCR cycles. In some embodiments, modeling of error rates can be applied in multi-contributor settings to more accurately establish real alleles from artifacts. Other aspects involve application of sequencing in error modeling. Further, methods are provided for determining the presence of common individual DNA profiles in one or more complex DNA mixtures and for deconvolution of multiple complex DNA mixtures into shared individual components.Type: GrantFiled: July 6, 2018Date of Patent: May 23, 2023Assignee: Massachusetts Institute of TechnologyInventors: Darrell Orlyn Ricke, James Harper, Brian S. Helfer, Joseph Isaacson, Adam M. Michaleas, Martha S. Petrovick, Eric Schwoebel, Anna Shcherbina, Philip Fremont-Smith, James G. Watkins, Edward C. Wack
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Publication number: 20210017592Abstract: The disclosure provides various systems and methods for identifying individuals from one or more samples. In particular, improved systems and methods of analysis are provided for handling multiple contributors, as well as systems and methods that model not only individual error rates per locus but factor in amplification of errors induced through PCR cycles. In some embodiments, modeling of error rates can be applied in multi-contributor settings to more accurately establish real alleles from artifacts. Other aspects involve application of sequencing in error modeling. Further, methods are provided for determining the presence of common individual DNA profiles in one or more complex DNA mixtures and for deconvolution of multiple complex DNA mixtures into shared individual components.Type: ApplicationFiled: July 6, 2018Publication date: January 21, 2021Applicant: Massachusetts Institute of TechnologyInventors: Darrell Orlyn Ricke, James Harper, Brian S. Helfer, Joseph Isaacson, Adam M. Michaleas, Martha S. Petrovick, Eric Schwoebel, Anna Shcherbina, Philip Fremont-Smith, James G. Watkins, Edward C. Wack
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Patent number: 9494579Abstract: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.Type: GrantFiled: September 9, 2014Date of Patent: November 15, 2016Assignee: Massachusetts Institute of TechnologyInventors: Eric D. Schwoebel, James D. Harper, Martha S. Petrovick, Frances E. Nargi, Todd H. Rider, Kristine E. Hogan, Richard H. Mathews, Joseph Lacirignola, Mark Hennessy, Trina R. Vian, Rose M. Joseph, Raymond S. Uttaro, Shaun Berry, Bernadette Johnson, Mark A. Hollis
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Patent number: 9291549Abstract: The invention described herein provides methods for the detection of target particles, such as pathogens, soluble antigens, nucleic acids, toxins, chemicals, plant pathogens, blood borne pathogens, bacteria, viruses and the like. Also described is an emittor cell comprising a receptor, wherein the receptor can be an antibody or an Fc receptor, and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more receptors on the emittor cell. Also provided are optoelectronic sensor devices for detecting a target particle in a sample, including in a plurality of samples.Type: GrantFiled: April 24, 2012Date of Patent: March 22, 2016Assignee: Massachusetts Institute of TechnologyInventors: Eric Schwoebel, James Harper, Martha S. Petrovick, Frances Nargi, Mark Hollis, Bernadette Johnson, Joseph Lacirignola, Richard Mathews, Kristine Hogan, Trina Vian, Allan Heff, Mark Hennessy, Songeeta Palchaudhuri, Todd Rider
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Publication number: 20150050723Abstract: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.Type: ApplicationFiled: September 9, 2014Publication date: February 19, 2015Inventors: Eric D. Schwoebel, James D. Harper, Martha S. Petrovick, Frances E. Nargi, Todd H. Rider, Kristine E. Hogan, Richard H. Mathews, Joseph Lacirignola, Mark Hennessy, Trina R. Vian, Rose M. Joseph, Raymond S. Uttaro, Shaun Berry, Bernadette Johnson, Mark A. Hollis
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Patent number: 8835127Abstract: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.Type: GrantFiled: October 6, 2011Date of Patent: September 16, 2014Assignee: Massachusetts Institute of TechnologyInventors: Eric D. Schwoebel, James D. Harper, Martha S. Petrovick, Frances E. Nargi, Todd H. Rider, Kristine E. Hogan, Richard H. Mathews, Joseph Lacirignola, Mark Hennessy, Trina R. Vian, Rose M. Joseph, Raymond S. Uttaro, Shaun Berry, Bernadette Johnson, Mark A. Hollis
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Publication number: 20120225423Abstract: The invention described herein provides methods for the detection of target particles, such as pathogens, soluble antigens, nucleic acids, toxins, chemicals, plant pathogens, blood borne pathogens, bacteria, viruses and the like. Also described is an emittor cell comprising a receptor, wherein the receptor can be an antibody or an Fc receptor, and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more receptors on the emittor cell. Also provided are optoelectronic sensor devices for detecting a target particle in a sample, including in a plurality of samples.Type: ApplicationFiled: April 24, 2012Publication date: September 6, 2012Applicant: Massachusetts Institute of TechnologyInventors: Eric Schwoebel, James Harper, Martha S. Petrovick, Frances Nargi, Mark Hollis, Bernadette Johnson, Joseph Lacirignola, Richard Mathews, Kristine Hogan, Trina Vian, Allan Heff, Mark Hennessy, Songeeta Palchaudhuri, Todd Rider
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Patent number: 8216797Abstract: The invention described herein provides methods for the detection of target particles, such as pathogens, soluble antigens, nucleic acids, toxins, chemicals, plant pathogens, blood borne pathogens, bacteria, viruses and the like. Also described is an emittor cell comprising a receptor, wherein the receptor can be an antibody or an Fc receptor, and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more receptors on the emittor cell. Also provided are optoelectronic sensor devices for detecting a target particle in a sample, including in a plurality of samples.Type: GrantFiled: November 30, 2006Date of Patent: July 10, 2012Assignee: Massachusetts Institute of TechnologyInventors: Eric Schwoebel, James Harper, Martha S. Petrovick, Frances Nargi, Mark Hollis, Bernadette Johnson, Joseph Lacirignola, Richard Mathews, Kristine Hogan, Trina Vian, Allan Heff, Mark Hennessy, Songeeta Palchaudhuri, Todd Rider
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Publication number: 20120135404Abstract: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.Type: ApplicationFiled: October 6, 2011Publication date: May 31, 2012Applicant: Massachusetts Institute of TechnologyInventors: Eric. D. Schwoebel, James D. Harper, Martha S. Petrovick, Frances E. Nargi, Todd H. Rider, Kristine E. Hogan, Richard H. Mathews, Joseph Lacirignola, Mark Hennessy, Trina R. Vian, Rose M. Joseph, Raymond S. Uttaro, Shaun Berry, Bernadette Johnson, Mark A. Hollis
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Patent number: 8067184Abstract: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.Type: GrantFiled: July 3, 2008Date of Patent: November 29, 2011Assignee: Massachusetts Institute of TechnologyInventors: Eric D. Schwoebel, James D. Harper, Martha S. Petrovick, Frances E. Nargi, Todd H. Rider, Kristine E. Hogan, Richard H. Mathews, Joseph Lacirignola, Mark Hennessy, Trina R. Vian, Rose M. Joseph, Raymond S. Uttaro, Shaun Berry, Bernadette Johnson, Mark A. Hollis
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Publication number: 20100062415Abstract: The invention described herein provides methods for the detection of target particles, such as pathogens, soluble antigens, nucleic acids, toxins, chemicals, plant pathogens, blood borne pathogens, bacteria, viruses and the like. Also described is an emittor cell comprising a receptor, wherein the receptor can be an antibody or an Fc receptor, and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more receptors on the emittor cell. Also provided are optoelectronic sensor devices for detecting a target particle in a sample, including in a plurality of samples.Type: ApplicationFiled: November 30, 2006Publication date: March 11, 2010Inventors: Eric Schwoebel, James Harper, Martha S. Petrovick, Frances Nargi, Mark Hollis, Bernadette Johnson, Joseph Lacirignola, Richard Mathews, Kristine Hogan, Trina Vian, Allan Heff, Mark Hennessy, Songeeta Palchaudhuri, Todd Rider
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Publication number: 20100041031Abstract: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.Type: ApplicationFiled: July 3, 2008Publication date: February 18, 2010Inventors: Eric D. Schwoebel, James D. Harper, Martha S. Petrovick, Frances E. Nargi, Todd H. Rider, Kristine E. Hogan, Richard H. Mathews, Joseph Lacirignola, Mark Hennessy, Trina R. Vian, Rose M. Joseph, Raymond S. Uttaro, Shaun Berry, Bernadette Johnson, Mark A. Hollis
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Publication number: 20090221056Abstract: Methods to produce cells that remain viable at ambient or non-refrigerated temperatures, or which can be stored in a dry state are described. In particular, cell preservation is for long term storage of cells, such as mammalian cells, at ambient or non-refrigerated temperatures, while retaining cell viability. Also provided are sensor cells that can detect target particles, biological agents or other materials and which remain viable at ambient or non-refrigerated temperatures, or which can be stored in a dry state.Type: ApplicationFiled: November 30, 2006Publication date: September 3, 2009Inventors: Martha S. Petrovick, Eric D. Schwoebel, Frances E. Nargi, James D. Harper, Todd H. Rider
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Patent number: 7422860Abstract: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.Type: GrantFiled: December 1, 2004Date of Patent: September 9, 2008Assignee: Massachusetts Institute of TechnologyInventors: Eric D. Schwoebel, James D. Harper, Martha S. Petrovick, Frances E. Nargi, Todd H. Rider, Kristine E. Hogan, Richard H. Mathews, Joseph Lacirignola, Mark Hennessy, Trina R. Vian, Rose M. Joseph, Raymond S. Uttaro, Shaun Berry, Bernadette Johnson, Mark A. Hollis
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Publication number: 20080166705Abstract: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.Type: ApplicationFiled: December 1, 2004Publication date: July 10, 2008Applicant: Massachusetts Institute of TechnologyInventors: Eric D. Schwoebel, James D. Harper, Martha S. Petrovick, Frances E. Nargi, Todd H. Rider, Kristine E. Hogan, Richard H. Mathews, Joseph Lacirignola, Mark Hennessy, Trina R. Vian, Rose M. Joseph, Raymond S. Uttaro, Shaun Berry, Bernadette Johnson, Mark A. Hollis