Abstract: A catheter system for ablation of tissue around a blood vessel, e.g., the pulmonary artery, to reduce neural activity of nerves surrounding the blood vessel. The catheter system includes an elongate shaft having a proximal portion coupled to a handle, and a distal portion. The distal portion includes a transducer and an expandable anchor, which may be actuated to transition between a collapsed delivery state and an expanded deployed state where the anchor centralizes the transducer within the blood vessel. The transducer may be actuated to emit energy to reduce neural activity of the nerves surrounding the blood vessel. Systems and method are further provided for confirming that neural activity of the nerves surround the blood vessel has been sufficiently reduced.

Abstract: Mutant Myxoma viruses are provided herein and methods of using these viruses to treat cancer or elicit an interferon response in a subject are also provided. The mutant Myxoma virus is modified to reduce or eliminate the activity or expression of Myxoma virus protein M62 as compared to a control virus. The mutant virus is capable of stimulating an interferon response in subjects after administration and can also lead to inhibition, reduction or elimination of the CD14+ tumor associated macrophage inhibition of CD4+ T cells in a subject having cancer and lead to a change in the tumor microenvironment to treat the cancer or work in combination with other cancer therapeutics to treat the cancer as described herein.

Abstract: A holster for securing a handgun to a wearer's body by way of a belt. The holster includes a body member having a central body portion which has an endless elastic loop member extending therearound. The body member has a first belt opening at one side of the central body portion and a second belt opening at the other side of the central body portion.

Abstract: A system and method, for obtaining and analyzing vascular data and generating results, that uses vascular test data to determine the state of the vessel. The data and the determinations can be used to generate reports, render diagnoses or identifying ailments, and may do so remotely. The system includes a telemedicine server and may include a number of other modules such as work stations, review tools, data storage modules, etc. The invention allows rapid and efficient analysis of the data, and provides mechanisms for comparing patient data to know or measured normative data sets, remotely if desired, and provides more accurate and less invasive diagnoses based on vascular conditions. The invention permits remote receipt, processing and distribution of the data and diagnoses.

Abstract: A method of manufacture of an insulated structural panel which includes the step of feeding and laminating of a pair of outer skins (13, 14) and a core of insulating material (8) interposed therebetween through a press bed (7) to facilitate adhesion of an adhesive to internal surfaces of each outer skin (13, 14) and thus facilitate bonding of the core of insulating material (8) to each adjacent internal surface of each outer skin (13, 14) wherein each outer skin (13, 14) has an outer surface which is gripped by a conveyor (26, 27) having a continuous working surface in contact with each of said outer surfaces (13, 14) characterised in that said continuous working surface is formed by a coating (40, 40A, 40B) of elastomer or other synthetic polymer applied to a metal substrate. There is also provided a laminating machine (10) for use in the method as well as a track plate (37) for use in the laminating machine (10).