Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

Abstract: This invention establishes a new paradigm for treatment of Parkinson's disease (PD) by eliminating senescent cells that reside in or around the site of the disease pathophysiology. Exposure of test subjects to the herbicide paraquat (PQ) increases the risk for developing Parkinson's disease. The data in this disclosure show that PQ induces a senescence arrest and SASP in astrocytes, in culture and in vivo in mice, and senescent cell markers were present in astrocytes in midbrain tissue from PD patients. In a transgenic mouse model, senescent cell ablation protected against PQ-induced PD-like neuropathology. Removal of senescent cells from affected sites using small molecule agents that specifically target senescent cells can help prevent or ameliorate signs and symptoms of the disease.

Abstract: A support apparatus for removably connecting fitness equipment to an exercise frame. The support apparatus can include first and second rack sections configured to be fixed in a spaced arrangement to a frame member, each rack section including at least one receiving channel having an opening at one end, and a bracket for supporting the exercise equipment.

Abstract: A weight training apparatus reconfigurable between an open configuration and a compact configuration in which the apparatus is packed into a smaller form than in the open configuration. The apparatus includes one or more storage compartments configured to removably receive and retain a weighted material to selectively increase the weight of the apparatus. If including more than one storage compartment, each can be movable relative to one other and are shaped and arranged to enable the apparatus to be reconfigured to the compact configuration in a filled condition in which the storage compartments contain weighted material. The apparatus can be configured in the compact configuration without weighted material for transport or storage. The absence of any weighted material makes the apparatus lightweight to carry, as well as enabling it to compact to a much smaller size than in the in-use filled configuration.

Abstract: A support apparatus for removably connecting fitness equipment to an exercise frame. The support apparatus can include first and second rack sections configured to be fixed in a spaced arrangement to a frame member, each rack section including at least one receiving channel having an opening at one end, and a bracket for supporting the exercise equipment.