Patents by Inventor Martin Farlow

Martin Farlow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of 1-aminocyclohexane derivatives to modify deposition of fibrillogenic a-beta peptides in amyloidopathies
    Publication number: 20050113458
    Abstract: The invention relates to the use of NMDA receptor antagonists such as 1-aminocyclohexane derivatives to modify deposition of potentially toxic and fibrillogenic A? peptides in amyloidopathies. Specifically, the invention relates to the ability of memantine to intervene in the processing of APP and decrease the levels of fibrillogenic A? peptides.
    Type: Application
    Filed: October 22, 2004
    Publication date: May 26, 2005
    Applicant: Forest Laboratories, Inc.
    Inventors: Sandeep Gupta, Pradeep Banerjee, Debomoy Lahiri, Martin Farlow
  • Methods and compositions for diagnosing tauopathies
    Publication number: 20020018995
    Abstract: The present invention relates generally to methods and compositions for the diagnosis, modeling and treatment of tau-related pathologies. In particular, the present invention shows that mutations in the tau gene lead to neurofibrillary tangle formation. More specifically gene mutations are described that lead to alterations in ratios of tau isoforms are shown to lead to the formation of abnormal tau filaments.
    Type: Application
    Filed: November 29, 2000
    Publication date: February 14, 2002
    Applicant: Advanced Research and Technology
    Inventors: Bernardino Ghetti, Maria Grazia Spillantini, Jill R. Murrell, Michel Goedert, Martin Farlow, Aaron Klug
  • Transgenic mouse expressing APP770-V717F
    Patent number: 6184435
    Abstract: Methods for screening for risk of Alzheimer's disease involve assaying for a guanine to thymine substitution at position 1924 of the gene encoding the human amyloid precursor protein. Also described are transgenic non-human mammals, especially transgenic mice, harboring an expressable gene sequence encoding human amyloid precursor protein having a phenyalanine for valine amino acid substitution in the transmembrane domain of the amyloid precursor protein.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 6, 2001
    Assignee: Advanced Research and Technology Institute
    Inventors: Merrill D. Benson, Jill Murrell, Martin Farlow, Bernardino Ghetti
  • Method for screening for alzheimer's disease
    Patent number: 5879883
    Abstract: Method for screening for risk of Alzheimer's disease involve assaying for a guanine to thymine substitution at position 1924 of the gene encoding the human amyloid precursor protein. Also described are transgenic mammals harboring an expressable gene sequence encoding human amyloid precursor protein having a phenyanine for valine amino acid substitution in the transmembrane domain of the amyloid precursor protein.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: March 9, 1999
    Assignee: Indiana University Foundation
    Inventors: Merrill D. Benson, Jill Murrell, Martin Farlow, Bernardino Ghetti