Patents by Inventor Martin FLECK

Martin FLECK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS
    Publication number: 20230257395
    Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: April 19, 2023
    Publication date: August 17, 2023
    Inventors: Florian Paul Christian BINDER, Thomas Martin FLECK, Jens WILLWACHER
  • Tetrazole derivatives as TRPA1 inhibitors
    Patent number: 11661430
    Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing the same.
    Type: Grant
    Filed: October 13, 2021
    Date of Patent: May 30, 2023
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Florian Paul Christian Binder, Thomas Martin Fleck, Jens Willwacher
  • TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS
    Publication number: 20220112210
    Abstract: The present disclosure provides certain tetrazole derivatives that are inhibitors of transient receptor potential ankyrin 1 (TRPA1), and are therefore useful for the treatment of diseases treatable by inhibition of TRPA1. Also provided are pharmaceutical compositions containing the same, and processes for preparing said compounds.
    Type: Application
    Filed: October 13, 2021
    Publication date: April 14, 2022
    Inventors: Florian Paul Christian BINDER, Thomas Martin FLECK, Jens WILLWACHER
  • MODIFIED CYCLIC DINUCLEOTIDE COMPOUNDS
    Publication number: 20210024567
    Abstract: Compounds of formula (I) wherein Base, R1 and R2 are defined as in claim 1, are modulators of STING.
    Type: Application
    Filed: March 22, 2019
    Publication date: January 28, 2021
    Inventors: Thorsten OOST, Martin FLECK, Christian Andreas KUTTRUFF
  • CYCLIC DINUCLEOTIDE COMPOUNDS CONTAINING 2-AZA-HYPOXANTHINE OR 6H-PYTAZOLO[1,5-D][1,2,4]TRIZAIN-7-ONE AS STRING AGONISTS
    Publication number: 20210009627
    Abstract: Compounds of formula I, wherein Base, R1 and R2 are defined as in claim 1, are modulators of STING.
    Type: Application
    Filed: March 22, 2019
    Publication date: January 14, 2021
    Inventors: Annekatrin Charlotte HEIMANN, Martin FLECK, Christian Andreas KUTTRUFF, Thorsten OOST
  • Cyclic dinucleotide compounds
    Patent number: 10537590
    Abstract: The present invention relates to compounds of general formula I, wherein the groups R1, R2 and R3 are defined as in claim 1, which have valuable pharmacological properties, particularly are modulators of STING.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: January 21, 2020
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Thorsten Oost, Sebastian Carotta, Martin Fleck
  • Modified cyclic dinucleotide compounds
    Patent number: 10392419
    Abstract: Compounds of formula (I) wherein Base1 and Base2 are defined as in claim 1 are modulators of STING.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: August 27, 2019
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Thorsten Oost, Martin Fleck, Christian Andreas Kuttruff, Sebastian Carotta
  • MODIFIED CYCLIC DINUCLEOTIDE COMPOUNDS
    Publication number: 20180273578
    Abstract: Compounds of formula (I) wherein Base1 and Base2 are defined as in claim 1 are modulators of STING.
    Type: Application
    Filed: March 20, 2018
    Publication date: September 27, 2018
    Inventors: Thorsten OOST, Martin FLECK, Christian Andreas KUTTRUFF, Sebastian CAROTTA
  • CYCLIC DINUCLEOTIDE COMPOUNDS
    Publication number: 20180092937
    Abstract: The present invention relates to compounds of general formula I, wherein the groups R1, R2 and R3 are defined as in claim 1, which have valuable pharmacological properties, particularly are modulators of STING.
    Type: Application
    Filed: September 27, 2017
    Publication date: April 5, 2018
    Inventors: Thorsten OOST, Sebastian CAROTTA, Martin FLECK
  • Tetrahydroisoquinoline derivatives, pharmaceutical compositions and uses thereof
    Patent number: 9340510
    Abstract: The invention relates to new pyrrolidine derivatives of the formula wherein R1 to R6, n and m are as defined in the description and claims, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: May 17, 2016
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Gerald Juergen Roth, Martin Fleck, Peter Wilhelm Haebel, Annekatrin Heimann, Niklas Heine
  • Tetrahydroisoquinoline derivatives, pharmaceutical compositions and uses thereof
    Publication number: 20160075657
    Abstract: The invention relates to new pyrrolidine derivatives of the formula wherein R1 to R6, n and m are as defined in the description and claims, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
    Type: Application
    Filed: September 16, 2015
    Publication date: March 17, 2016
    Inventors: Gerald Juergen ROTH, Martin FLECK, Peter Wilhelm HAEBEL, Annekatrin HEIMANN, Niklas HEINE
  • Pyrrolidine derivatives, pharmaceutical compositions and uses thereof
    Patent number: 9278954
    Abstract: Pyrrolidine derivatives which are inhibitors of acetyl-CoA carboxylase(s) and their use in the treatment of obesity and type-2 diabetes. An exemplary compound is 2-(4-(1-[5-Chloro-6-(2-hydroxy-2-methyl-propoxy)-pyrimidin-4-yl]-(R)-pyrrolidin-3-yloxy)-phenyl)-N-cyclopropyl-propionamide.
    Type: Grant
    Filed: May 12, 2014
    Date of Patent: March 8, 2016
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Niklas Heine, Martin Fleck, Bernd Nosse, Gerald Juergen Roth
  • Pyrrolidine derivatives, pharmaceutical compositions and uses thereof
    Patent number: 9169205
    Abstract: Pyrrolidine derivatives of the formula and their use as medicaments for the treatment of obesity and type 2 diabetes.
    Type: Grant
    Filed: October 1, 2013
    Date of Patent: October 27, 2015
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Martin Fleck, Niklas Heine, Bernd Nosse, Gerald Juergen Roth, Annekatrin Heimann
  • Compounds, pharmaceutical compositions and uses thereof
    Patent number: 9006450
    Abstract: The invention relates to new piperidine derivatives of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: April 14, 2015
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Gerald Juergen Roth, Martin Fleck, Thorsten Lehmann-Lintz, Heike Neubauer, Bernd Nosse
  • Pyrimidine-substituted pyrrolidine derivatives, pharmaceutical compositions and uses thereof
    Patent number: 8962641
    Abstract: The invention relates to new pyrrolidine derivatives of the formula wherein R1 to R3, Ar, L T and n are as defined in the description and claims, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: April 7, 2014
    Date of Patent: February 24, 2015
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Martin Fleck, Annekatrin Heimann, Niklas Heine, Bernd Nosse, Gerald Juergen Roth
  • Pyrrolidine derivatives, pharmaceutical compositions and uses thereof
    Publication number: 20140343083
    Abstract: Pyrrolidine derivatives which are inhibitors of acetyl-CoA carboxylase(s) and their use in the treatment of obesity and type-2 diabetes. An exemplary compound is 2-(4-(1-[5-Chloro-6-(2-hydroxy-2-methyl-propoxy)-pyrimidin-4-yl]-(R)-pyrrolidin-3-yloxy)-phenyl)-N-cyclopropyl-propionamide.
    Type: Application
    Filed: May 12, 2014
    Publication date: November 20, 2014
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Niklas HEINE, Martin FLECK, Bernd NOSSE, Gerald Juergen ROTH
  • Compounds, pharmaceutical compositions and uses thereof
    Patent number: 8877754
    Abstract: The invention relates to new compounds of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: November 4, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Gerald Juergen Roth, Martin Fleck, Heike Neubauer, Bernd Nosse
  • Pyrrolidine derivatives, pharmaceutical compositions and uses thereof
    Patent number: 8877741
    Abstract: The invention relates to new pyrrolidine derivatives of the formula to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: November 4, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Martin Fleck, Niklas Heine, Bernd Nosse, Gerald Juergen Roth
  • PYRIMIDINE-SUBSTITUTED PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
    Publication number: 20140315882
    Abstract: The invention relates to new pyrrolidine derivatives of the formula wherein R1 to R3, Ar, L T and n are as defined in the description and claims, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
    Type: Application
    Filed: April 7, 2014
    Publication date: October 23, 2014
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Martin FLECK, Annekatrin HEIMANN, Niklas HEINE, Bernd NOSSE, Gerald Juergen ROTH
  • Compounds, pharmaceutical compositions and uses thereof
    Patent number: 8835472
    Abstract: The invention relates to new compounds of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: September 16, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Gerald Juergen Roth, Martin Fleck, Niklas Heine, Joerg Kley, Thorsten Lehmann-Lintz, Heike Neubauer, Bernd Nosse