Patents by Inventor Martin FREESMEYER

Martin FREESMEYER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11701439
    Abstract: The invention relates to compounds according to the general formula (I) or a pharmaceutically acceptable salt of an inorganic or organic acid, a hydrate, a stereoisomer or a solvate thereof, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 being selected independently of one another from hydrogen and alkoxy. The compounds of formula (I) as ligands are suitable for the production of radioactively labelled 68Ga, 64Cu, 67Ga, 111In or 99mTc complexes. The invention further relates to a method for producing the compounds of formula (I) and the radioactively labelled complexes and to the use of the radioactively labelled complexes in imaging methods, such as PET/CT, in particular of the liver.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: July 18, 2023
    Assignee: X-NUCLEAR DIAGNOSTICS GMBH
    Inventors: Martin Freesmeyer, Julia Greiser
  • Publication number: 20210069357
    Abstract: The invention relates to compounds according to the general formula (I) or a pharmaceutically acceptable salt of an inorganic or organic acid, a hydrate, a stereoisomer or a solvate thereof, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 being selected independently of one another from hydrogen and alkoxy. The compounds of formula (I) as ligands are suitable for the production of radioactively labelled 68Ga, 64Cu, 67Ga, 111In or 99mTc complexes. The invention further relates to a method for producing the compounds of formula (I) and the radioactively labelled complexes and to the use of the radioactively labelled complexes in imaging methods, such as PET/CT, in particular of the liver.
    Type: Application
    Filed: December 10, 2018
    Publication date: March 11, 2021
    Applicant: UNIVERSITÄTSKLINIKUM JENA
    Inventors: Martin FREESMEYER, Julia GREISER
  • Patent number: 10524748
    Abstract: A method for determining the locations of origin of radiation signals in a measurement zone in which radiation signals are detected from the measurement zone by means of a quantity of radiation detectors at a measurement time, and measurement values associated with the measurement time are provided. The determination of the locations of origin is carried out taking into account the measurement values of all of the radiation detectors and of the known positional relationships of the radiation detectors relative to one another using a reference dataset. The measuring device of the invention, for the simultaneous detection of radiation events of decaying radionuclides in the measurement zone has a quantity of radiation detectors provided in a measuring head. An ultrasound probe may be arranged in the measuring head. Detection, determination and imaging of a two-dimensional intensity distribution of radiation signals of a radionuclide is possible in the entire measurement zone.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: January 7, 2020
    Assignee: Universitaetsklinikum Jena
    Inventor: Martin Freesmeyer
  • Publication number: 20170119327
    Abstract: A method for determining the locations of origin of radiation signals in a measurement zone in which radiation signals are detected from the measurement zone by means of a quantity of radiation detectors at a measurement time, and measurement values associated with the measurement time are provided. The determination of the locations of origin is carried out taking into account the measurement values of all of the radiation detectors and of the known positional relationships of the radiation detectors relative to one another using a reference dataset. The measuring device of the invention, for the simultaneous detection of radiation events of decaying radionuclides in the measurement zone has a quantity of radiation detectors is provided in a measuring head. An ultrasound probe may be arranged in the measuring head. Detection, determination and imaging of a two-dimensional intensity distribution of radiation signals of a radionuclide is possible in the entire measurement zone.
    Type: Application
    Filed: June 11, 2015
    Publication date: May 4, 2017
    Inventor: Martin FREESMEYER
  • Publication number: 20150305700
    Abstract: A combined nuclear and ultrasonic system for hybrid imaging is proposed. It comprises a hand-held nuclear radiation detector, a hand-held ultrasonic probe, a nuclear tracking system for tracking the nuclear radiation detector while measuring a nuclear radiation and obtaining nuclear radiation detector coordinates representing a position of the tracked nuclear radiation detector in relation to an image coordinate system of a hybrid image, an ultrasonic tracking system for tracking of the ultrasonic probe during the receiving of ultrasonic signals so that ultrasonic probe coordinates are obtained which represent a position of the tracked ultrasonic probe in relation to an image coordinate system of the hybrid image, and a data acquisition module, which gathers the nuclear radiation detector measurements, nuclear radiation detector coordinates, ultrasonic signals from the ultrasonic probe, and ultrasonic probe coordinates, and matches them with an image coordinate system of a hybrid image.
    Type: Application
    Filed: November 25, 2013
    Publication date: October 29, 2015
    Inventors: Thomas WENDLER, Stefan WIESNER, Jörg TRAUB, Martin FREESMEYER