Patents by Inventor Martin Hajnsek
Martin Hajnsek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210148888Abstract: A sensor arrangement for detecting information indicative of a physiological substance in blood of a physiological subject, wherein the sensor arrangement has a first sensor structure configured for electrochemically sensing the physiological substance in at least part of the blood, wherein detecting the physiological substance is influenceable by hemolysis of the blood, a second sensor structure configured for electrochemically sensing a parameter in at least part of the blood, which parameter is indicative of hemolysis of the blood, and a plasma separation unit configured for separating plasma from the blood and arranged so that the separated plasma is supplied to the first sensor structure and the second sensor structure, whereas a rest of the blood is kept apart from the first sensor structure and the second sensor structure.Type: ApplicationFiled: August 9, 2018Publication date: May 20, 2021Inventors: Bruna Pekec, Martin Hajnsek
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Patent number: 9993187Abstract: A sensor arrangement for detecting information indicative of a physiological substance in a body material of a physiological subject, wherein the sensor arrangement comprises a substrate, a first sensor structure connected to the substrate and being configured for sensing the physiological substance electrochemically, and a second sensor structure connected to the substrate and being configured for sensing the physiological substance by a luminescence detection.Type: GrantFiled: January 22, 2015Date of Patent: June 12, 2018Assignee: JOANNEUM RESEARCH FORSCHUNGSGESELLSCHAFT MBH & CO. KGInventor: Martin Hajnsek
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Publication number: 20170290538Abstract: An in vivo amperometric sensor is provided for measuring the concentration of an analyte in a body fluid. The sensor comprises a counter electrode and a working electrode, and the working electrode comprises a sensing layer which is generally water permeable and arranged on a support member adjacent to a contact pad. The sensing layer comprises an immobilized enzyme capable of acting catalytically in the presence of the analyte to cause an electrical signal. The sensing layer has an upper surface facing the body fluid and a lower surface facing away from the body fluid, and the immobilized enzyme is distributed within the sensing layer in such a way that the enzyme concentration in the middle between the upper and lower surfaces is at least as high as on the upper surface of the sensing layer.Type: ApplicationFiled: June 23, 2017Publication date: October 12, 2017Inventors: Arnulf Staib, Reinhold Mischler, Martin Hajnsek, Harvey Buck, Walter Jernigan
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Patent number: 9700252Abstract: An in vivo amperometric sensor is provided for measuring the concentration of an analyte in a body fluid. The sensor comprises a counter electrode and a working electrode, and the working electrode comprises a sensing layer which is generally water permeable and arranged on a support member adjacent to a contact pad. The sensing layer comprises an immobilized enzyme capable of acting catalytically in the presence of the analyte to cause an electrical signal. The sensing layer has an upper surface facing the body fluid and a lower surface facing away from the body fluid, and the immobilized enzyme is distributed within the sensing layer in such a way that the enzyme concentration in the middle between the upper and lower surfaces is at least as high as on the upper surface of the sensing layer.Type: GrantFiled: August 2, 2013Date of Patent: July 11, 2017Assignee: Roche Diabetes Care, Inc.Inventors: Arnulf Staib, Reinhold Mischler, Martin Hajnsek, Harvey Buck, Walter Jernigan
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Publication number: 20170000396Abstract: An in vivo amperometric sensor is provided for measuring the concentration of an analyte in a body fluid. The sensor comprises a counter electrode and a working electrode, and the working electrode comprises a sensing layer which is generally water permeable and arranged on a support member adjacent to a contact pad. The sensing layer comprises an immobilized enzyme capable of acting catalytically in the presence of the analyte to cause an electrical signal. The sensing layer has an upper surface facing the body fluid and a lower surface facing away from the body fluid, and the immobilized enzyme is distributed within the sensing layer in such a way that the enzyme concentration in the middle between the upper and lower surfaces is at least as high as on the upper surface of the sensing layer.Type: ApplicationFiled: August 2, 2013Publication date: January 5, 2017Applicant: Roche Diagnostics Operations, Inc.Inventors: Arnulf Staib, Reinhold Mischler, Martin Hajnsek, Harvey Buck, Walter Jernigan
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Publication number: 20150223742Abstract: A sensor arrangement for detecting information indicative of a physiological substance in a body material of a physiological subject, wherein the sensor arrangement comprises a substrate a first sensor structure connected to the substrate and being configured for sensing the physiological substance electrochemically, and a second sensor structure connected to the substrate and being configured for sensing the physiological substance by a luminescence detection.Type: ApplicationFiled: January 22, 2015Publication date: August 13, 2015Inventor: Martin Hajnsek
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Publication number: 20150038814Abstract: An in vivo amperometric sensor is provided for measuring the concentration of an analyte in a body fluid. The sensor comprises a counter electrode and a working electrode, and the working electrode comprises a sensing layer which is generally water permeable and arranged on a support member adjacent to a contact pad. The sensing layer comprises an immobilized enzyme capable of acting catalytically in the presence of the analyte to cause an electrical signal. The sensing layer has an upper surface facing the body fluid and a lower surface facing away from the body fluid, and the immobilized enzyme is distributed within the sensing layer in such a way that the enzyme concentration in the middle between the upper and lower surfaces is at least as high as on the upper surface of the sensing layer.Type: ApplicationFiled: August 2, 2013Publication date: February 5, 2015Applicant: Roche Diagnostics Operations, Inc.Inventors: Arnulf Staib, Reinhold Mischler, Martin Hajnsek, Harvey Buck, Walter Jernigan
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Patent number: 8871068Abstract: The disclosure concerns a high efficiency electrochemical sensor with high signal yield for determining an analyte in a fluid medium comprising, at least one reference electrode, at least one working electrode having particles of an electrocatalyst in an electrode matrix, and an enzyme that is suitable for determining an analyte is selectively covalently bound to the particles of the electrocatalyst. The disclosure also describes a process for producing the electrochemical sensor and a method for determining an analyte in a fluid medium using the electrochemical sensor. have a high efficiency and thus achieve a high signal yield.Type: GrantFiled: July 18, 2008Date of Patent: October 28, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Arnulf Staib, Thomas Meier, Reinhold Mischler, Harald Peschel, Martin Hajnsek
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Patent number: 8527024Abstract: An in vivo amperometric sensor is provided for measuring the concentration of an analyte in a body fluid. The sensor comprises a counter electrode and a working electrode, and the working electrode comprises a sensing layer which is generally water permeable and arranged on a support member adjacent to a contact pad. The sensing layer comprises an immobilized enzyme capable of acting catalytically in the presence of the analyte to cause an electrical signal. The sensing layer has an upper surface facing the body fluid and a lower surface facing away from the body fluid, and the immobilized enzyme is distributed within the sensing layer in such a way that the enzyme concentration in the middle between the upper and lower surfaces is at least as high as on the upper surface of the sensing layer.Type: GrantFiled: December 19, 2008Date of Patent: September 3, 2013Assignee: Roche Diagnostics Operations, Inc.Inventors: Arnulf Staib, Reinhold Mischler, Martin Hajnsek, Harvey Buck, Walter Jernigan
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Publication number: 20090099433Abstract: An in vivo amperometric sensor is provided for measuring the concentration of an analyte in a body fluid. The sensor comprises a counter electrode and a working electrode, and the working electrode comprises a sensing layer which is generally water permeable and arranged on a support member adjacent to a contact pad. The sensing layer comprises an immobilized enzyme capable of acting catalytically in the presence of the analyte to cause an electrical signal. The sensing layer has an upper surface facing the body fluid and a lower surface facing away from the body fluid, and the immobilized enzyme is distributed within the sensing layer in such a way that the enzyme concentration in the middle between the upper and lower surfaces is at least as high as on the upper surface of the sensing layer.Type: ApplicationFiled: December 19, 2008Publication date: April 16, 2009Inventors: Arnulf Staib, Reinhold Mischler, Martin Hajnsek, Harvey Buck, Walter Jernigan
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Publication number: 20090071846Abstract: The disclosure concerns a high efficiency electrochemical sensor with high signal yield for determining an analyte in a fluid medium comprising, at least one reference electrode, at least one working electrode having particles of an electrocatalyst in an electrode matrix, and an enzyme that is suitable for determining an analyte is selectively covalently bound to the particles of the electrocatalyst. The disclosure also describes a process for producing the electrochemical sensor and a method for determining an analyte in a fluid medium using the electrochemical sensor. have a high efficiency and thus achieve a high signal yield.Type: ApplicationFiled: July 18, 2008Publication date: March 19, 2009Inventors: Arnulf Staib, Thomas Meier, Reinhold Mischler, Harald Peschel, Martin Hajnsek
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Patent number: 7297241Abstract: The invention relates to a method and device for the monitoring of a medical microsample in the flow measuring cell of an analyzer with regard to position and absence of bubbles by means of an alternating voltage applied to the measuring cell, the measuring cell being provided with a multitude of electrode systems placed one behind the other, each system comprising a number of single electrodes for measuring a substance contained in the microsample by means of a measurement voltage which essentially is a DC voltage. To monitor the exact position of the microsample and/or to detect air bubbles in the area of each electrode system, the alternating voltage and the measurement voltage are simultaneously and directly applied to the single electrodes of the corresponding electrode system, and the measured AC component respectively the measured impedance gives a measure for the position of the microsample and the absence of bubbles.Type: GrantFiled: August 22, 2003Date of Patent: November 20, 2007Assignee: Roche Diagnostics Operations, Inc.Inventors: Heinz Kontschieder, Herfried Huemer, Martin Hajnsek
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Publication number: 20060011493Abstract: The invention relates to a method and device for the monitoring of a medical microsample (P) in the flow measuring cell (1) of an analyzer with regard to position and absence of bubbles by means of an alternating voltage applied to the measuring cell (1), said measuring cell (1) being provided with a multitude of electrode systems (2, 3) placed one behind the other, each system comprising a number of single electrodes (WE, RE, CE) for measuring a substance contained in the microsample (P) by means of a measurement voltage which essentially is a DC voltage. To monitor the exact position of the microsample (P) and/or to detect air bubbles in the area of each electrode system, the alternating voltage and the measurement voltage are simultaneously and directly applied to the single electrodes (WE, RE, CE) of the corresponding electrode system (2, 3), and the measured AC component respectively the measured impedance gives a measure for the position of the microsample (P) and the absence of bubbles.Type: ApplicationFiled: August 22, 2003Publication date: January 19, 2006Inventors: Heinz Kontschieder, Herfried Huemer, Martin Hajnsek