Abstract: The invention relates to an arrangement of a machine tool (10) and a workpiece holder (111) connected to a workpiece (14), wherein the workpiece holder (111) comprises at least one surface (111a) pointing radially towards the outside, in particular a substantially planar surface, which is configured for contact with a clamping element (109) of a multi-axis workpiece arm (11) which clamping element (109) is disposed in the radial direction between the workpiece holder (111) and a chuck (120), wherein the clamping element (109) is displaceable relative to the chuck (120) for clamping and releasing the workpiece holder (111), wherein the clamping element (109) is configured to vary a clamping force (F) exerted on the workpiece holder (111) when it is displaced relative to the chuck (120).

Abstract: The invention is directed to a method for determining a monomer sequence of a polymer that is translocated through a nanopore. Monomers of the polymer are labeled with fluorescent labels such that in free solution fluorescent labels of adjacent monomers substantially quench each other and wherein the nanopore constrains fluorescent labels within its bore into a constrained state wherein no detectable fluorescent signal can be generated. By exciting the fluorescent label of each monomer as it exits the nanopore and transitions from a constrained state to a quenched state with an adjacent fluorescent label, a fluorescent signal can be generated by the exiting fluorescent label that allows its monomer to be identified, thereby permitting a monomer sequence to be determined from a sequence of fluorescent signals as the polymer translocates through the nanopore.

Abstract: A user interacts with a medical imaging system and a medical reporting system to prepare a medical report. The medical reporting system includes report templates for medical reports. The report templates include placeholder fields with unique placeholder designations and metadata. After a user entry in the medical imaging system to select an image dataset, the image dataset and analysis tools are made available to the user. After a user entry in the medical reporting system to select a report template, a report template is made available. Placeholders contained in the selected report template are displayed with corresponding placeholder designations and metadata, automatically sent to the imaging system, and displayed as data requests. According to the data requests displayed, the data corresponding to the data requests is ascertained or determined by the user and assigned to the placeholder designations. A report editor automatically saves the data in the placeholder fields.

Abstract: The present invention relates to a process for synthesis of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol abbreviated THIP, having the INN name gaboxadol, starting from pyrrolidin-2-one. The process comprises a new direct process to obtain the intermediate dimethyl 5-hydroxy-3,6-dihydropyridine-1,4(2H)-dicarboxylate or the intermediate diethyl 5-hydroxy-3,6-dihydropyridine-1,4(2H)-dicarboxylate.

Abstract: The invention relates to a dosing system for an inhalation device which is capable of aliquoting a precise and accurately metered volume from a larger pre-defined fill volume. The dosing system comprises a filling chamber for receiving a liquid to be aerosolized, the filling chamber having a lateral wall, an inlet opening and an outlet opening with a closing means (11) for closing the outlet opening. The dosing system further comprises an overflow chamber surrounding the inlet opening of the filling chamber and a plunger which can be inserted, at least partially, into the filling chamber, and which sealingly contacts the lateral wall such as to displace liquid from said filling chamber upon insertion, and push a metered volume of the liquid out from the filling chamber through the outlet opening and feed it to the nebulizing means of the inhalation device.

Abstract: The present invention relates to a process for synthesis of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol abbreviated THIP, having the INN name gaboxadol, starting from pyrrolidin-2-one. The process comprises a new direct process to obtain the intermediate dimethyl 5-hydroxy-3,6-dihydropyridine-1,4(2H)-5 dicarboxylate or the intermediate diethyl 5-hydroxy-3,6-dihydropyridine-1,4(2H)-dicarboxylate.

Abstract: The invention is directed to a method for determining a monomer sequence of a polymer that is translocated through a nanopore. Monomers of the polymer are labeled with fluorescent labels such that in free solution fluorescent labels of adjacent monomers substantially quench each other and wherein the nanopore constrains fluorescent labels within its bore into a constrained state wherein no detectable fluorescent signal can be generated. By exciting the fluorescent label of each monomer as it exits the nanopore and transitions from a constrained state to a quenched state with an adjacent fluorescent label, a fluorescent signal can be generated by the exiting fluorescent label that allows its monomer to be identified, thereby permitting a monomer sequence to be determined from a sequence of fluorescent signals as the polymer translocates through the nanopore.

Abstract: Methods are provided for the treatment of RSV infections in young children. More specifically, methods are provided wherein polypeptides that bind F protein of hRSV and that neutralize RSV infection are administered to the lungs of young children at specific dose regimens.

Abstract: An electrical connector includes at least two electrical connector elements extending side by side along a longitudinal direction, each of the electrical connector elements being connectable to a respective wire of an associated electrical cable. An electrical device is in electrical contact with the respective electrical connector elements. A flexible carrier bears inwardly against the electrical connector elements. The electrical device is mounted on an inner side of the flexible carrier which faces the connector elements.

Abstract: The invention relates to a machine tool (1), in particular a dental milling machine or mill-turning machine, comprising a spindle (10) for receiving a tool and a working arm (12) for receiving a workpiece and comprising at least one nozzle (14a) attached to the spindle (10), in particular with its outlet direction (R) substantially parallel to the axis of rotation (A) of the spindle (10), characterized in that a deflecting body (16) is attached to the spindle (10) or clamped therein, said deflecting body extending in particular at least partially in front of the nozzle (14a). Further, the invention relates to a method of operating the machine tool (1).

Abstract: An interconnection includes a cable assembly and a board assembly. The cable assembly includes a cable having an inner conductor. The board assembly comprises an intermediate layer disposed between first and second outer layers, a recess disposed between the first and second outer layers so as to form a cable-receiving space at a first side edge, and a first inner-conductor contact opening extending through at least one of the first and second outer layers and opening into the cable-receiving space. The inner conductor is inserted at the first side edge into the cable-receiving space and is disposed at an offset in a longitudinal direction relative to the first inner-conductor contact opening. The inner conductor is electrically conductively soldered via a first soldered inner-conductor connection to a first inner-conductor connection region of the first and/or second outer layers, at least in a region of the first inner-conductor contact opening.

Abstract: The invention is directed to methods and apparatus for detecting sequences of optical signals from parallel reactions on an array of nanostructures, such as nanopores, nanowells, or nanoparticles. In accordance with the invention, an array of nanostructures is provided, each nanostructure comprising a reaction site and each capable of confining a reaction that generates a sequence of optical signals, and the nanostructures of the array being arranged in clusters each comprising a number of nanostructures. Each different cluster is disposed within a different resolution limited area and the number of nanostructures in each cluster is either greater than one or a random variable with an average value greater than zero. Optical signals from reactions in the nanostructures are detected by an optical system operatively associated with the array.

Abstract: An electrical connector for a multi-wire electrical cable includes at least two cable-side electrical contact elements, including associated terminals to each of which is to be connected a wire of the electrical cable, and at least two output-side electrical contact elements, from each of which projects an electrical connector element by which an electrical connection is establishable to a mating connector. A carrier body is disposed between the cable-side electrical contact elements and the output-side electrical contact elements. The cable-side electrical contact elements, the output-side electrical contact elements and the carrier body are disposed in a spaced-apart relationship to each other, and the cable-side and output-side contact elements are electrically connected to each other via an electrical device disposed on the carrier body.

Abstract: An electrical connector includes at least two electrical connector elements extending side by side along a longitudinal direction, each of the electrical connector elements being connectable to a respective wire of an associated electrical cable. An electrical device is in electrical contact with the respective electrical connector elements. A flexible carrier bears inwardly against the electrical connector elements. The electrical device is mounted on an inner side of the flexible carrier which faces the connector elements.

Abstract: An inhalation device, assembly or system can include a kit and a pharmaceutical composition. The device can be adapted for administering therapeutic aerosols to pediatric patients, including neonates, infants or toddlers. The device can further include a vibrating mesh aerosol generator that can be insertable into a flow channel of the inhalation device through a lateral opening, and a valved face mask. The device can be connectable to a gas source through which a gas, such as oxygen, can be received into the flow channel at a low flow rate.

Abstract: A dental milling machine comprising a workpiece holder (2) and a changer arm (10) is characterized in that the changer arm (10) has a substantially U-shaped gripping attachment (12) and in that a tool (14) of the dental milling machine (1) has a tool fixation element (16). The tool fixation element has grooves (18) or holding projections at two mutually opposed positions which face away from each other, over which grooves or holding projections the U-shaped gripping attachment (12) of the changer arm (10) can engage, wherein parts of the U-shaped gripping attachment (12), more particularly the side flanks (12a, 12b) of the U-shaped gripping attachment (12), make contact with the grooves (18) or holding projections of the tool fixation element (16) under preload.

Abstract: Various methods, systems and devices for optical detection and analysis of polymers, such as polynucleotides, using nanopores, e.g., for determining sequences of nucleic acids, are provided herein. In certain variations, methods and systems for determining a nucleotide sequence of a polynucleotide, which include measuring mixed FRET signals as a polynucleotide translocates through a nanopore and determining a nucleotide sequence of the polynucleotide from the mixed FRET signals, are provided.

Abstract: A method for processing a wide band gap semiconductor wafer is proposed. The method includes depositing a non-monocrystalline support layer at a back side of a wide band gap semiconductor wafer, depositing an epitaxial layer at a front side of the wide band gap semiconductor wafer, and splitting the wide band gap semiconductor wafer along a splitting region to obtain a device wafer including at least a part of the epitaxial layer, and a remaining wafer including the non-monocrystalline support layer.

Abstract: The invention relates to a machining device for the machine-assisted production and machining of dental workpieces (16), particularly of artificial teeth and/or other dental replacement parts, the at least one workpiece (16) being clamped in at least one workpiece retainer (11) which can be raised, lowered and rotatably driven, is positioned on a rotational axis (9), and, for the purpose of machining, feeds said workpiece (16) to at least one tool spindle (4, 5, 6) that is rotationally driven and has a tool (7) secured thereto, an additional tool retainer (2, 2a, 2b) with a plurality of tools (7) arranged thereupon being associated with said workpiece retainer (11, 11a, 11b) and lying opposite on one side thereof, and a workpiece changer (22, 22a, 22b) which receives the workpieces (16, 16a, 16b, 16c) to be machined, such that they can be exchanged, being arranged on the other side of said workpiece retainer (11, 11a, 11b).