Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30).

Abstract: A method and system for identifying scale. The method may include disposing a fluid sampling tool into a wellbore. The fluid sampling tool may comprise at least one probe configured to fluidly connect the fluid sampling tool to a formation in the wellbore and at least one passageway that passes through the at least one probe and into the fluid sampling tool. The method may further comprise drawing a formation fluid, as a fluid sample, through the at least one probe and through the at least one passageway, perturbing the formation fluid, and analyzing the fluid sample in the fluid sampling tool for one or more indications of scale.

Abstract: The present disclosure is directed toward systems and methods for an augmented reality transportation system. For example, the systems and methods described herein present an augmented reality environment for a driver or a passenger including augmented reality elements to mark specific locations within a display of real-world surroundings. Additionally, the systems and methods described herein analyze historical information to determine placements for augmented reality elements. The systems and methods also enable a user to share an augmented reality or virtual reality environment with another user.

Abstract: The present invention relates to methods of determining the presence or absence of certain cancers in a human individual, as well as to related methods to determine the response to therapy against certain cancers in a human individual, in particular ovarian cancer in a woman. Such methods are based on the detection-from (eg cell-free) DNA of said human individual—of one or more methylated (or un-methylated) CpGs being associated with differentially methylated regions (DMRs) of the present invention; such as methylation (or un-methylation) at one or more or all of certain CpGs being associated with such DMRs. Accordingly, such methods have diagnostic, prognostic and/or predictive utility for detecting or managing certain cancers in women or men, in particular ovarian cancer in women.

Abstract: A method for estimating a rate of penetration while drilling a subterranean wellbore includes estimating a first rate of penetration while drilling using a first measurement method, estimating a second rate of penetration while drilling using a second measurement method, and combining the first and second rates of penetration to obtain a combined rate of penetration of drilling.

Abstract: In one aspect the invention is arranged to provide a hair treatment apparatus adapted to reduce the temperature of hair. This apparatus includes at least one thermal energy storage core arranged to draw heat out of hair wherein said at least one thermal energy storage core is arranged to cool hair to a temperature below 0° Celsius.

Abstract: The invention provides methods and compositions for breeding pepper (Capsicum sp. such as Capsicum annuum) lines, including isogenic and nearly isogenic lines, displaying one or more mature fruit color(s) of interest. Predictive genetic markers and associated sequences and primers, associated with phenotypic diversity at the Ccs locus encoding Capsanthin-Capsorubin Synthase, and the Ze locus encoding Zeaxanthin Epoxidase are also provided, as well as methods for breeding pepper lines. Further provided are pepper plants, and plant parts including seeds, seed mixtures, fruit, and packaged fruit, which display mature fruit color(s) of interest.

Abstract: An apparatus and method are provided for speculatively vectorising program code. The apparatus includes processing circuitry for executing program code, the program code including an identified code region comprising at least a plurality of speculative vector memory access instructions. Execution of each speculative vector memory access instruction is employed to perform speculative vectorisation of a series of scalar memory access operations using a plurality of lanes of processing. Tracking storage is used to maintain, for each speculative vector memory access instruction, tracking information providing an indication of a memory address being accessed within each lane. Checking circuitry then references the tracking information during execution of the identified code region by the processing circuitry, in order to detect any inter lane memory hazard resulting from the execution of the plurality of speculative vector memory access instructions.

Abstract: In one aspect the invention provides a boat support frame loading and unloading apparatus configured to draw a boat on to and off a boat support frame. This boat support frame has a loading end and a terminal end opposite to the loading end. The apparatus provided includes at least one roller assembly mounted to the support frame adjacent to the loading end of the support frame, said at least one roller assembly incorporating at least one roller element. The apparatus also includes at least one drive mechanism configured to rotate one or more roller elements to draw a boat onto and off the support frame through the loading end of the support frame. The roller assembly also includes a hull contact surface formed by a flexible belt which has a circumference greater than the circumference of the said at least one roller element incorporated into the roller assembly.

Abstract: The present disclosure provides pepper plants exhibiting resistance to Phytophthora capsici. Such plants may comprise novel introgressed chromosomal regions associated with disease resistance. In certain aspects, compositions, including novel polymorphic markers and methods for producing, breeding, identifying, and selecting plants or germplasm with a disease resistance phenotype are provided.

Abstract: The invention provides methods and compositions for breeding pepper (Capsicum sp. such as Capsicum annuum) lines, including isogenic and nearly isogenic lines, displaying one or more mature fruit color(s) of interest. Predictive genetic markers and associated sequences and primers, associated with phenotypic diversity at the Ccs locus encoding Capsanthin-Capsorubin Synthase, and the Ze locus encoding Zeaxanthin Epoxidase are also provided, as well as methods for breeding pepper lines. Further provided are pepper plants, and plant parts including seeds, seed mixtures, fruit, and packaged fruit, which display mature fruit color(s) of interest.

Abstract: An apparatus comprises a main processor to execute a main stream of program instructions, two or more checker processors to execute respective checker streams of program instructions in parallel with each other, the checker streams corresponding to different portions of the main stream executed by the main processor, and error detection circuitry to detect an error when a mismatch is detected between an outcome of a given portion of the main stream executed on the main processor and an outcome of the corresponding checker stream executed on one of the plurality of checker processors. This approach enables high performance main processors 4 to be checked for errors with lower circuit area and power consumption overhead than a dual-core lockstep technique.

Abstract: The present disclosure provides pepper plants exhibiting resistance to Phytophthora capsici. Such plants may comprise novel introgressed chromosomal regions associated with disease resistance. In certain aspects, compositions, including novel polymorphic markers and methods for producing, breeding, identifying, and selecting plants or germplasm with a disease resistance phenotype are provided.

Abstract: A main processor 4 executes a main program and has an associated cache memory 6. Event detection circuitry 12 detects events consequent upon execution of the main program and indicative of data to be used by the main processor. One or more programmable further processors 16, 18 is triggered to execute a further program by the events detected by the event detection circuitry 12. Prefetch circuitry 28 is responsive to the further program executed by the one or more programmable further processors to trigger prefetching of the data to be used by the main processor to the cache memory.

Abstract: The invention provides methods and compositions for breeding pepper (Capsicum sp. such as Capsicum annuum) lines, including isogenic and nearly isogenic lines, displaying one or more mature fruit color(s) of interest. Predictive genetic markers and associated sequences and primers, associated with phenotypic diversity at the Ccs locus encoding Capsanthin-Capsorubin Synthase, and the Ze locus encoding Zeaxanthin Epoxidase are also provided, as well as methods for breeding pepper lines. Further provided are pepper plants, and plant parts including seeds, seed mixtures, fruit, and packaged fruit, which display mature fruit color(s) of interest.

Abstract: An apparatus comprises a main processor to execute a main stream of program instructions, two or more checker processors to execute respective checker streams of program instructions in parallel with each other, the checker streams corresponding to different portions of the main stream executed by the main processor, and error detection circuitry to detect an error when a mismatch is detected between an outcome of a given portion of the main stream executed on the main processor and an outcome of the corresponding checker stream executed on one of the plurality of checker processors. This approach enables high performance main processors 4 to be checked for errors with lower circuit area and power consumption overhead than a dual-core lockstep technique.

Abstract: In one aspect the invention provides a boat support frame loading and unloading apparatus configured to draw a boat on to and off a boat support frame. This boat support frame has a loading end and a terminal end opposite to the loading end. The apparatus provided includes at least one roller assembly mounted to the support frame adjacent to the loading end of the support frame, said at least one roller assembly incorporating at least one roller element. The apparatus also includes at least one drive mechanism configured to rotate one or more roller elements to draw a boat onto and off the support frame through the loading end of the support frame. The roller assembly also includes a hull contact surface formed by a flexible belt which has a circumference greater than the circumference of the said at least one roller element incorporated into the roller assembly.

Abstract: In one aspect the invention provides a boat support frame loading and unloading apparatus configured to draw a boat on to and off a boat support frame. This boat support frame has a loading end and a terminal end opposite to the loading end. The apparatus provided includes at least one roller assembly mounted to the support frame adjacent to the loading end of the support frame, said at least one roller assembly incorporating at least one roller element. The apparatus also includes at least one drive mechanism configured to rotate one or more roller elements to draw a boat onto and off the support frame through the loading end of the support frame. The roller assembly also includes a hull contact surface formed by a flexible belt which has a circumference greater than the circumference of the said at least one roller element incorporated into the roller assembly.

Abstract: A main processor 4 executes a main program and has an associated cache memory 6. Event detection circuitry 12 detects events consequent upon execution of the main program and indicative of data to be used by the main processor. One or more programmable further processors 16, 18 is triggered to execute a further program by the events detected by the event detection circuitry 12. Prefetch circuitry 28 is responsive to the further program executed by the one or more programmable further processors to trigger prefetching of the data to be used by the main processor to the cache memory.

Abstract: The present disclosure provides pepper plants exhibiting resistance to Phytophthora capsici. Such plants may comprise novel introgressed chromosomal regions associated with disease resistance. In certain aspects, compositions, including novel polymorphic markers and methods for producing, breeding, identifying, and selecting plants or germplasm with a disease resistance phenotype are provided.