Abstract: The invention relates to cobalamin derivatives (a) having no binding affinity or low binding affinity to the transport protein transcobalamin II TCII) and (b) retaining activity as a vitamin B12 substitute, optionally carrying a therapeutic and/or diagnostic agent, such as a radioactive metal. These compounds have a much reduced accumulation rate in blood and benign organs, such as kidney and liver, compared to the accumulation rate in neoplastic tissues, and are more rapidly eliminated from blood. The invention further relates to a method of diagnosis and a method of treatment of a neoplastic disease or an infection by microorganisms in a mammal comprising (a) exposing the mammal to a period of a vitamin B12-free diet, and (b) subsequently applying a cobalamin derivative of the invention carrying a diagnostic and/or therapeutic agent. By selecting cobalamin derivatives acting as vitamin B12 substitutes, the risk of the formation of resistant offspring in neoplastic tissue is much reduced.

Abstract: The invention relates to a computer application in the field of control, monitoring, modification and/or optimization of processes which comprise real process sequences of discrete events, so-called “discrete event dynamic systems”, which cannot usually be described by systems of (differential) equations. Such processes occur for example in technical developments as well as in other business activities in the industrial or tertiary sector. Such a real process is reflected in a process model which is connected to the real process via at least one interface. If the interface(s) is/are bi-directional, real process data can be transmitted into the model directly, i.e. without data conversion, and thus the real process can be monitored; in the model, simulations can be carried out with changed process data; and finally if the result of the simulation is successful, process modifications can be transferred directly to the real process.

Abstract: This invention relates to the structure and design of a method and a system for designing and implementing Web and similar applications in an automated, computerized way, in particular without any computer programming. In principle, this is achieved by literally drawing a process model expressing what the desired Web application should do, then preferably simulating and/or testing the desired application, and finally automatically enabling the application by using the process model as the controlling engine of the designed application. The latter is done by uploading the designed process model to a server or computer network thus implementing it as run-time application. No other workflow system or similar additional software nor any special hardware is required.

Abstract: The present invention relates to novel facultative methylotrophic microorganisms of the genus Hyphomicrobium, to protein-containing biomass, and to a process for the microbiological purification of aqueous solutions, e.g. wastewaters, which contain methanol, ethanol, glucose, dimethyl phosphite, trimethyl phosphite, sodium formate, sodium acetate, methylammonium chloride, dimethylammonium chloride, ethylmethylammonium chloride or, chiefly, sodium methyl sulfate, as pollutants. The respective microorganism is cultured in aqueous solution and the pollutant is degraded simultaneously.

Abstract: The present invention relates to novel facultative methylotrophic microorganisms of the genus Pseudomonas, or of a genus Pseudomonas-type genus, to protein-containing biomass, and to a process for the microbiological purification of aqueous solutions, e.g. wastewater solutions, which contain methanol, ethanol, acetate, glucose, alkylammonium compounds, e.g., trimethylethylammonium chloride, or alkylamine oxides, e.g. trimethylamine oxide, as pollutants.