Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Abstract: A brake dust particle filter for a disc brake assembly with a brake disc and a brake caliper is provided, the brake dust particle filter being configured to collect particles resulting from braking, wherein the brake dust filter comprises: a housing comprising a first and a second side wall which are arranged opposite to each other and a peripheral wall connecting the first and the second side wall; wherein the first side wall comprises at least one guiding element protruding towards the second side wall within the housing, the guiding element having a face which is arranged opposite to a peripheral wall section of the peripheral wall; and the brake dust particle filter is configured to accommodate the brake disc between a distal edge of the guiding element and the second side wall.

Abstract: Harvesting vehicle, in particular forage harvester or combine harvester, comprising a mounting frame (10), wherein the mounting fame (10) is designed to couple an attachment to the mounting frame (10) and via the mounting frame (10) to the harvesting vehicle, and comprising a drive coupler (16) which engages with the mounting frame (10) and which is designed to form a drive connection between the attachment and the harvesting vehicle in order to transmit a drive power provided by the harvesting vehicle in the direction of the attachment, wherein the drive coupler (16) has a drive hub (17) which can be coupled to the harvesting vehicle, a coupling disk (19) which can be coupled to the attachment and a centering mandrel (22) which cooperates with the attachment, wherein the centering mandrel (22) is fixedly engaged with the coupling disk (19), a slide piece (24) which can be displaced in a translatory manner relative to the drive hub (17) is coupled fixedly in terms of rotation to the drive hub (17), and wherei

Abstract: A filter element for filtering a fluid has a filter body with a filter medium folded in a zigzag shape with folds extending in a fold direction. The filter body has an end edge bonding which seals fold ends of the folds. The filter body has an outer contour with recesses. The end edge bonding, in a region of the recesses of the outer contour of the filter body, is embodied discontinuously. The end edge bonding has at least one outwardly positioned first bonding segment and an inwardly positioned second bonding segment, viewed in the fold direction. The inwardly positioned second bonding segment, in a transverse direction relative to the fold direction, is arranged at a spacing to the at least one outwardly positioned first bonding segment. The at least one outwardly positioned first bonding segment and the inwardly positioned second bonding segment bond at least one common fold.

Abstract: The subject matter is the assembly of a containment means with an aseptic working chamber and associated decontamination arrangement. The working chamber is delimited at the bottom by a base, and above the working chamber is a circulating air zone, in which a circulating air filter with a circulating air fan is arranged. The circulating air zone and the working chamber are delimited towards the outside by a housing. At least a first returning air channel leads from the working chamber into the circulating air zone. A returning air filter is fluidically connected to the returning air channel, specifically is arranged facing the circulating air zone. The returning air filter can be arranged at the opening of the returning air channel into the circulating air zone or arranged in the circulating air channel, set back from the opening. The returning air filter and the circulating air filter are in the form of a plate filter or an exchangeable filter cartridge or a replaceable filter insert.

Abstract: The arrangement is provided for monitoring state and sequence of movement in an aseptic work chamber of a containment standing in an installation room. At least one work glove projects into the work chamber, wherein the respective work glove is able to stretch up to a maximum grasping range in the three spatial axes in the work chamber. The arrangement comprises a tracking system, the recordings of which serve to continuously localize the at least one work glove in three dimensions and are stored in a computer unit. At least one three-dimensional or two-dimensional prohibited region, which may be adjoined by a warning region, is defined in the work chamber. Individual surface sections or the entire floor of the containment can be defined as a prohibited region. A prohibited region and possibly a warning region in front of this can be set up around machines which are installed in the work chamber and which constitute a danger for the operator.

Abstract: The system comprising containment equipment is intended for the aseptic transfer of a powder, namely for emptying a container filled with powder into a collection container and/or for filling a container with powder from a storage container. The containment equipment has a working chamber surrounded by a housing. A robot is installed in the containment equipment, having an arm arrangement that moves over a pivot range. If there is a collection container it has an inlet leading from the working chamber, and if there is a storage container it has an outlet leading off into the working chamber. The container can be closed at least with a first closure element. A transfer head is mounted at the inlet into the collection container and/or at the outlet of the storage container, each protruding into the working chamber. The passive part forms the double flap together with an active part contained in the transfer head.

Abstract: A work glove is installed at the port flange, with the result that the operator can enter the working chamber of the containment in a protected manner. A multiplicity of port flanges are usually mounted on the containment and a work glove is fastened in each case to the respective port flange. Machinery for processing material to be treated is often set up in the working chamber. In order to temporarily block the access, a shut-off part which can be moved into a blocking position and an open position is provided. In order to record personal data relating to the operator, the arrangement has a capture unit which has a connection to a microcontroller.

Abstract: The present invention is related to production of a sterol mix in a modified yeast cell, wherein the amount of zymosterol present in said mix is dramatically reduced or abolished via modification of sterol acyltransferase activity within said yeast. The modified yeast cell can be used for production of vitamin D3 or derivatives and/or metabolites thereof.

Abstract: The invention relates to a glove device (4), the glove (3) of which is provided for protected intervention in a working chamber (11) of a containment (1) through an access (24) present in a port flange (2). The port flange (2) is built into a front panel (12) or into a wall of a housing (10) of the containment (1) positioned in an installation area (19). Machinery (13) for processing goods to be treated can be provided in the working chamber (11). The glove device (4) is designed as an assembly in the form of an insert which can be inserted into the port flange (2) in a gas-tight manner, said glove device comprising, on one side, a seal (41) which can be removed or is to be opened and, on the other side, a cover part (7) or a shut-off part (5) which is releasable from the assembly, and the vacuum-packed glove (3) between these two sides. The glove device (4) also has a fixing part (40) which is intended for gas-tight fastening to the port flange (2) and between which the seal (41) is gripped.

Abstract: A constant velocity joint having an inner hub, an annular outer hub, a plurality of balls and a shaft connection component, with the outer hub in contact with the shaft connection component. The shaft connection component has, at an end region facing the outer hub, a securing structure which is in contact with a contacting structure of the outer hub. The outer hub contacting structure includes recesses corresponding to the raised portions of shaft connection component. The raised portions engage in the recesses to form a securing structure. The tracks and the recesses of the outer hub are arranged axially in alignment with each other.

Abstract: A rotor for an electric motor includes a shaft having a central portion supporting a laminated core of an electrical sheet material. The central portion is also composed of an electrical sheet material. The ends of the rotor shaft may be formed from a different material than the material of the central portion, and may be connected to the central portion by a force-fitting interference fit and/or a knurled interference fit. An electric motor having such a rotor and a method for producing a such a rotor are provided.

Abstract: A multi-modal multi-media air filtration system which can include: a base having one or more connection features and a filter media assembly, the filter media assembly being configured to attach to the base portion at a first end. The filter media assembly can then also include a first filter media extending across a first air flow path and a second filter media extending across a second air flow path. The air filtration assembly can then also include an actuation assembly configured to selectively open or close one of the first air flow path or the second air flow path so as to alternate the degree of filtration passing through the filter media assembly based on the degree of filtration provided by the first or second filter media.

Abstract: A joint arrangement includes comprising a joint, a nut and an adapter unit. The joint has an inner hub, an outer hub, balls and a cage with recesses for the balls. The inner hub has a recess with an inner toothing for receiving a first shaft. A cavity of the joint arrangement located around the balls is closed on two end sides by a respective sealing device. The adapter unit includes a first adapter portion and a second adapter portion which cooperate to transmit torque across the joint arrangement to or from a second shaft.

Abstract: The present invention is related to an improved method for production of 7-dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention features modified yeast strains expressing enzymes having improved C-8 sterol isomerase activity leading to increased ratios of 7-DHC in the sterol mix.

Abstract: The present invention is related to an improved method for production of 7-dehydrocholesterol (7-DHC), an important intermediate towards biotechnological production of vitamin D3 or derivatives/metabolites thereof. The invention features modified host strains expressing enzymes having improved C-5 sterol 5 desaturase activity and their use in a process for production of vitamin D3 or derivatives and/or metabolites thereof.

Abstract: The present invention is related to production of a sterol mix in a modified yeast cell, wherein the amount of zymosterol present in said mix is dramatically reduced or abolished via modification of sterol acyltransferase activity within said yeast. The modified yeast cell can be used for production of vitamin D3 or derivatives and/or metabolites thereof.

Abstract: A train station has at least one transportation route for traffic of vehicles, wherein the at least one transportation route is provided with a vehicle tunnel. At least one public waiting area is arranged adjacent to the at least one transportation route. An enclosure is provided in which the at least one public waiting area is arranged, wherein the enclosure has at least one side wall. At least one ambient air purification arrangement for purifying ambient air is provided that has one or more filter units for separating solid, liquid or gaseous ambient air pollutants from the ambient air. The one or more filter units are arranged at and/or in the at least one side wall of the enclosure.

Abstract: The present invention is related to modified sterol acyltransferase enzymes with improved activity and/or specificity towards acylation of the vitamin D3 precursor 7-dehydrocholesterol (7-DHC) to be used in biotechnological production of vitamin D3. The invention further relates to a yeast strain expressing said modified enzymes and their use in a process for production of vitamin D3 or derivatives and/or metabolites thereof.