Abstract: A lateral flow assay device of the present disclosure has numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. The vent pockets have protrusions to help prevent accidental resealing. The device also can have a gasket to ensure free air movement between open vent pockets. Flow control features that protrude horizontally into a chamber proximal to an outlet act to deflect the flow to the side of the chamber opposite from the outlet, prior to the flow entering the outlet. Such features can reduce the flow velocity of the sample fluid and increase the effective fluid flow path length, enhance mixing of reagents with a sample, and enabling more accurate control of fluid flow in the device.

Abstract: An automated method for performing an assay of the present disclosure can be performed in a microfluidic device that is a lateral flow device having numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. Each chamber can have a reagent recess proximal to an inlet end of the chamber. A reagent pellet formed in a reagent recess can be effectively mixed with a sample as the sample flows into the chamber. A flexible circuit with patterned metallic electrical components disposed on a heat stable material can be in direct contact with fluid in the chambers and has resistive heating elements aligned with, for example, a chamber for performing an amplification reaction.

Abstract: Method and apparatus are provided for processing a sample on a slide. A capillary processing module has a crank to raise and lower a slide, and/or a side inlet to apply a fluid to the slide. A capillary gap is formed between the slide and a chamber floor of the capillary processing module when the crank has lowered the slide. Capillary action causes the fluid to spread through the capillary space across a processing area and to contact the sample. When the crank raises the slide, the fluid is withdrawn from the processing area of the slide because the capillary gap is eliminated.

Abstract: Techniques to permit a digital image capture device to stabilize a video stream in real-time (during video capture operations) are presented. In general, techniques are disclosed for stabilizing video images using an overscan region and a look-ahead technique enabled by buffering a number of video input frames before generating a first stabilized video output frame. (Capturing a larger image than is displayed creates a buffer of pixels around the edge of an image; overscan is the term given to this buffer of pixels.) More particularly, techniques are disclosed for buffering an initial number of input frames so that a “current” frame can use motion data from both “past” and “future” frames to adjust the strength of a stabilization metric value so as to keep the current frame within its overscan. This look-ahead and look-behind capability permits a smoother stabilizing regime with fewer abrupt adjustments.

Abstract: An image is compressed according to a compression ratio selected based on a compression metric. In one embodiment, the compression metric is based on image characteristics indicative of the amount of image noise in an image, such as gain and lux. Greater compression ratios are used for image having compression metrics indicating a higher degree of noise. Because an image with higher image noise levels already has a reduced visual quality, the impact of higher compression is less significant as compared to the impact of compression on images having low image noise. In an embodiment, an image is divided into a number of regions, for each of which a compression metric and corresponding compression ratio is determined, so that regions of the image having high image noise may be compressed more than regions having low image noise.

Abstract: Techniques to permit a digital image capture device to stabilize a video stream in real-time (during video capture operations) are presented. In general, techniques are disclosed for stabilizing video images using an overscan region and a look-ahead technique enabled by buffering a number of video input frames before generating a first stabilized video output frame. (Capturing a larger image than is displayed creates a buffer of pixels around the edge of an image; overscan is the term given to this buffer of pixels.) More particularly, techniques are disclosed for buffering an initial number of input frames so that a “current” frame can use motion data from both “past” and “future” frames to adjust the strength of a stabilization metric value so as to keep the current frame within its overscan. This look-ahead and look-behind capability permits a smoother stabilizing regime with fewer abrupt adjustments.

Abstract: Techniques to permit a digital image capture device to stabilize a video stream in real-time (during video capture operations) are presented. In general, techniques are disclosed for stabilizing video images using an overscan region and a look-ahead technique enabled by buffering a number of video input frames before generating a first stabilized video output frame. (Capturing a larger image than is displayed creates a buffer of pixels around the edge of an image; overscan is the term given to this buffer of pixels.) More particularly, techniques are disclosed for buffering an initial number of input frames so that a “current” frame can use motion data from both “past” and “future” frames to adjust the strength of a stabilization metric value so as to keep the current frame within its overscan. This look-ahead and look-behind capability permits a smoother stabilizing regime with fewer abrupt adjustments.

Abstract: An image is compressed according to a compression ratio selected based on a compression metric. In one embodiment, the compression metric is based on image characteristics indicative of the amount of image noise in an image, such as gain and lux. Greater compression ratios are used for image having compression metrics indicating a higher degree of noise. Because an image with higher image noise levels already has a reduced visual quality, the impact of higher compression is less significant as compared to the impact of compression on images having low image noise. In an embodiment, an image is divided into a number of regions, for each of which a compression metric and corresponding compression ratio is determined, so that regions of the image having high image noise may be compressed more than regions having low image noise.

Abstract: Techniques to permit a digital image capture device to stabilize a video stream in real-time (during video capture operations) are presented. In general, techniques are disclosed for stabilizing video images using an overscan region and a look-ahead technique enabled by buffering a number of video input frames before generating a first stabilized video output frame. (Capturing a larger image than is displayed creates a buffer of pixels around the edge of an image; overscan is the term given to this buffer of pixels.) More particularly, techniques are disclosed for buffering an initial number of input frames so that a “current” frame can use motion data from both “past” and “future” frames to adjust the strength of a stabilization metric value so as to keep the current frame within its overscan. This look-ahead and look-behind capability permits a smoother stabilizing regime with fewer abrupt adjustments.

Abstract: A jaw crusher has a substantially fixed jaw and an opposed movable jaw. A pair of opposed side walls extend from either side of the jaws to define a crushing zone. Each side wall includes one or a plurality of side liners configured to protect the side walls. A security or capture projection extends from the side wall to one side and adjacent to each side liner and prevents the side liner from falling downward from the crushing zone in the event of dislodgement from its mounting position during use.

Abstract: In one embodiment, the invention relates to a method of detecting cervical cancer, and other types of cancer, using a combination of at least three genomic clones, or fragments thereof, of high risk Human Papilloma Virus. For example, the invention relates to a composition comprising at least three full length genomic clones, or fragments thereof, of high risk Human Papilloma Viruses.

Abstract: In one embodiment, the invention relates to a method of detecting cervical cancer, and other types of cancer, using a combination of at least three genomic clones, or fragments thereof, of high risk Human Papilloma Virus. For example, the invention relates to a composition comprising at least three full length genomic clones, or fragments thereof, of high risk Human Papilloma Viruses.

Abstract: In one embodiment, the invention relates to a method of detecting cervical cancer, and other types of cancer, using a combination of at least three genomic clones, or fragments thereof, of high risk Human Papilloma Virus. For example, the invention relates to a composition comprising at least three full length genomic clones, or fragments thereof, of high risk Human Papilloma Viruses.

Abstract: A biological sample processing system for on-site liquid production comprises a processing apparatus for processing of biological samples arranged on microscope slides, and a production unit connected to the apparatus. The production unit comprises a first ingredient source, a second ingredient source, and a mixer station. The mixer station is configured to mix ingredients to produce a liquid product. Supply conduits are arranged to supply an amount of a first ingredient and an amount of a second ingredient from the first and second ingredient sources to the mixer station. A delivery conduit is provided for transportation of an amount of the liquid product from the mixer station. A production controller is arranged in communication with the production unit, and is configured to control the operation of the production unit.

Abstract: A method, apparatus and system for automated removal of an embedding medium from an embedded biological sample. The method comprising the steps of: providing an automated sample processing apparatus having an automated process operation capability that causes automated process operation events through robotic sample process functions; providing a clearing solvent, e.g. an organic solvent, capable of lowering the melting point of an embedding medium and/or dissolving an embedding medium; loading a plurality of carriers with embedded biological samples in the automated sample processing apparatus; exposing an embedded biological sample to the clearing solvent, whereby the embedding medium is liquefied; and providing a washing solution capable of removing the clearing solvent and the liquefied embedded medium from said biological sample, said clearing solvent and said washing solution being immiscible.

Abstract: A new fibrinogen binding protein or polypeptide originating from coagulase negative staphylococci, biotechnological methods for producing the protein or polypeptide having fibrinogen binding activity and a recombinant DNA molecule coding for the protein (or fragments thereof), and micro-organisms (including viruses) containing this recombinant DNA molecule. The present invention further comprises the therapeutic and diagnostic use of the protein and/or DNA, e.g., a diagnostic kit for determining the presence and/or type of coagulase negative staphylococci and a vaccine composition, comprising the protein or DNA.

Abstract: In one embodiment, the invention relates to a method of detecting cervical cancer, and other types of cancer, using a combination of at least three genomic clones, or fragments thereof, of high risk Human Papilloma Virus. For example, the invention relates to a composition comprising at least three full length genomic clones, or fragments thereof, of high risk Human Papilloma Viruses.

Abstract: There is disclosed a method of pre-treatment and staining, according to a protocol, of a biological sample disposed upon the surface of a carrier, the method comprising the step of recording at least one parameter relating to at least one protocol step in a non-volatile memory located either upon or within the carrier or a device incorporating the carrier. Also disclosed is a device comprising: a non-volatile memory; a surface of the device adapted to carry a biological sample; and communications means electrically coupled to the memory for enabling data transmission to or from an external apparatus. Also disclosed is a method of controlling processing of a biological sample disposed upon a carrier, comprising: providing, upon or within the carrier or an apparatus holding the carrier, a non-volatile memory having information relating to sample processing priority or protocol; reading the information; and scheduling the processing based upon the information.

Abstract: A new fibrinogen binding protein or polypeptide originating from coagulase negative staphylococci, biotechnological methods for producing the protein or polypeptide having fibrinogen binding activity and a recombinant DNA molecule coding for the protein (or fragments thereof), and micro-organisms (including viruses) containing this recombinant DNA molecule. The present invention further comprises the therapeutic and diagnostic use of the protein and/or DNA, e.g., a diagnostic kit for determining the presence and/or type of coagulase negative staphylococci and a vaccine composition, comprising the protein or DNA.

Abstract: A new fibrinogen binding protein or polypeptide originating from coagulase negative staphylococci, biotechnological methods for producing the protein or polypeptide having fibrinogen binding activity and a recombinant DNA molecule coding for the protein (or fragments thereof), and micro-organisms (including viruses) containing this recombinant DNA molecule. The present invention further comprises the therapeutic and diagnostic use of the protein and/or DNA, e.g., a diagnostic kit for determining the presence and/or type of coagulase negative staphylococci and a vaccine composition, comprising the protein or DNA.