Patents by Inventor Martin Markowitz

Martin Markowitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MOLECULAR CLONE OF HIV-1
    Publication number: 20130177583
    Abstract: The present invention relates, in general, to HIV-1 and, in particular, to a molecular clone of HIV-1. The invention further relates to methods of inducing an immune response to HIV-1 in a patient and to immunogens suitable for use in such methods. The invention also relates to anti-HIV-1 antibodies and to methods of using same to prevent or treat HIV-infection.
    Type: Application
    Filed: March 3, 2011
    Publication date: July 11, 2013
    Applicants: Duke University, The UAB Research Foundation
    Inventors: George M. Shaw, Beatrice H. Hahn, Hui Li, Barton F. Haynes, Martin Markowitz
  • Protease assay for therapeutic drug monitoring
    Patent number: 7320878
    Abstract: The present invention concerns a further development and use of biological assays to determine the amount or concentration of an active ingredient present in a sample. The enzyme assay of the present invention determines the amount or concentration of protease inhibitors, including retroviral protease inhibitors such as HIV inhibitors.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: January 22, 2008
    Assignees: Tibotec Pharmaceuticals, Ltd., Aaron Diamond Aids Research Center, The Rockefeller University
    Inventors: Sergei Gulnik, Betty Yu, John W Erickson, Martin Markowitz
  • Protease assay for therapeutic drug monitoring
    Publication number: 20050221286
    Abstract: The present invention concerns a further development and use of biological assays to determine the amount or concentration of an active ingredient present in a sample. The enzyme assay of the present invention determines the amount or concentration of protease inhibitors, including retroviral protease inhibitors such as HIV inhibitors.
    Type: Application
    Filed: November 8, 2002
    Publication date: October 6, 2005
    Inventors: Sergei Gulnik, Betty Yu, John Erickson, Martin Markowitz
  • Vaccination of hiv infected persons following highly active antiretrovial therapy
    Publication number: 20040034209
    Abstract: The present invention provides a method of permitting cessation of antiviral therapy on HIV-infected subjects without virus rebound or with at least a delayed virus rebound or a decreased post rebound set-point. The method comprises the re-induction of HIV-specific immune responses using a vaccination strategy to induce both humoral and cell-mediated immunity. The present invention achieves an immunological control of persistent infectious virus after discontinuation of antiviral therapy. The vaccine strategy according to the invention is both safe and immunogenic in the subject HIV-infected patient population.
    Type: Application
    Filed: October 9, 2002
    Publication date: February 19, 2004
    Inventors: David Ho, Martin Markowitz, MICHEL KLEIN, RAPHAELLE EL HABIB