Abstract: A turbocharger includes a waste gate valve, a compressor, a turbine, a turbine housing which houses the turbine, a bypass channel which includes an opening cross-section, the bypass channel bypassing the turbine, a bypass channel portion formed in the turbine housing, an actuator housing which includes a separate first coolant channel having a coolant inlet port and a coolant outlet port, an electric motor arranged in the actuator housing, a transmission which includes an output shaft, the transmission being arranged in the actuator housing, and a control body coupled to the output shaft. The actuator housing is formed separately and is secured to the turbine housing. The control body controls the opening cross-section of the bypass channel.

Abstract: A coolant pump for an internal combustion engine. The coolant pump includes a delivery duct, a drive shaft, a coolant pump impeller arranged on the drive shaft to rotate therewith and to convey a coolant, and an adjustable control slide which controls a throughflow cross-section of an annular gap arranged between an outlet of the coolant pump impeller and the surrounding delivery duct. The control slide comprises a first pressure chamber arranged on a side of the control slide facing away from the coolant pump impeller and a second pressure chamber arranged opposite thereto. A control pump includes a control pump impeller arranged at the drive shaft to rotate therewith. A connecting duct fluidically connects the flow duct to the second pressure chamber. A pressure duct fluidically connects the flow duct outlet to the first pressure chamber. A valve opens and closes a throughflow cross-section of the pressure duct.

Abstract: A turbocharger includes a waste gate valve, a compressor with a turbine, a turbine housing which houses the turbine, a bypass channel with an opening cross-section, a bypass channel portion formed in the turbine housing, an actuator housing with a separate coolant channel, an electric motor arranged in the actuator housing, a transmission with an output shaft, the transmission being arranged in the actuator housing and being provided as a worm wheel gear unit, and a control body coupled to the output shaft of the transmission. The bypass channel bypasses the turbine. The actuator housing is removably secured to the turbine housing. The control body controls the opening cross-section of the bypass channel.

Abstract: A valve unit includes a positioning device for converting a rotary motion into a linear motion, a valve rod, a drive unit, a drive shaft with an eccentric arranged thereon, a coupling element comprising a slot, and an output shaft arranged at the eccentric which moves in the slot of the coupling element. The valve rod is connected with the coupling element. The valve rod is linearly movable with the coupling element between an initial position where the valve is closed and an end position. The slot comprises a guide path which cooperates with the eccentric having an angle with a plane perpendicular to a direction of movement of the adjusting element. The initial position of the eccentric is a position which is located before a dead center existing for an axial movement of the output shaft. The dead center is passed during a rotational movement of the drive shaft.

Abstract: A coolant pump for an internal combustion engine. The coolant pump includes a delivery duct, a drive shaft, a coolant pump impeller arranged on the drive shaft to rotate therewith and to convey a coolant, and an adjustable control slide which controls a throughflow cross-section of an annular gap arranged between an outlet of the coolant pump impeller and the surrounding delivery duct. The control slide comprises a first pressure chamber arranged on a side of the control slide facing away from the coolant pump impeller and a second pressure chamber arranged opposite thereto. A control pump includes a control pump impeller arranged at the drive shaft to rotate therewith. A connecting duct fluidically connects the flow duct to the second pressure chamber. A pressure duct fluidically connects the flow duct outlet to the first pressure chamber. A valve opens and closes a throughflow cross-section of the pressure duct.

Abstract: A turbocharger includes a waste gate valve, a compressor, a turbine, a turbine housing which houses the turbine, a bypass channel which bypasses the turbine, a bypass channel section arranged in the turbine housing, an actuator housing which has a separate coolant channel, an electric motor arranged in the actuator housing, a transmission which has an output shaft, a control body coupled to the output shaft, and an actuator cover. The transmission is arranged in the actuator housing. The actuator housing is detachably secured to the turbine housing. The control body controls an opening cross-section of the bypass channel. The separate coolant channel of the actuator housing surrounds a circumference of the transmission and is closed axially by the actuator cover.

Abstract: The present invention generally relates to the methods and use of clonal evolution analysis of the kinetics and genetic alterations associated with the development of resistance to a therapy using whole-exome and deep targeted sequencing in treating patients in need thereof.

Abstract: A spring arrangement for a variable valve drive of an internal combustion engine includes an intermediate lever, a control shaft, a control shaft roller, a working cam contour, and a spring element. The intermediate lever comprises a contact surface, a camshaft roller which bears against a camshaft, and a slot roller which bears against a slotted guide. The control shaft roller is arranged on the intermediate lever to face away from the slotted guide. The control shaft roller bears against the control shaft. The working cam contour is formed at an end of the intermediate lever opposite the camshaft roller. The spring element comprises a force component on the contact surface in the direction of the camshaft and the slotted guide, and an end leg. The spring element loads the camshaft roller against the camshaft and the slot roller against the slotted guide. The end leg bears against the contact surface.

Abstract: A turbocharger includes a waste gate valve, a compressor, a turbine, a turbine housing which houses the turbine, a bypass channel which includes an opening cross-section, the bypass channel bypassing the turbine, a bypass channel portion formed in the turbine housing, an actuator housing which includes a separate first coolant channel having a coolant inlet port and a coolant outlet port, an electric motor arranged in the actuator housing, a transmission which includes an output shaft, the transmission being arranged in the actuator housing, and a control body coupled to the output shaft. The actuator housing is formed separately and is secured to the turbine housing. The control body controls the opening cross-section of the bypass channel.

Abstract: A turbocharger includes a waste gate valve, a compressor with a turbine, a turbine housing which houses the turbine, a bypass channel with an opening cross-section, a bypass channel portion formed in the turbine housing, an actuator housing with a separate coolant channel, an electric motor arranged in the actuator housing, a transmission with an output shaft, the transmission being arranged in the actuator housing and being provided as a worm wheel gear unit, and a control body coupled to the output shaft of the transmission. The bypass channel bypasses the turbine. The actuator housing is removably secured to the turbine housing. The control body controls the opening cross-section of the bypass channel.

Abstract: A turbocharger includes a waste gate valve, a compressor, a turbine, a turbine housing which houses the turbine, a bypass channel which bypasses the turbine, a bypass channel section arranged in the turbine housing, an actuator housing which has a separate coolant channel, an electric motor arranged in the actuator housing, a transmission which has an output shaft, a control body coupled to the output shaft, and an actuator cover. The transmission is arranged in the actuator housing. The actuator housing is detachably secured to the turbine housing. The control body controls an opening cross-section of the bypass channel. The separate coolant channel of the actuator housing surrounds a circumference of the transmission and is closed axially by the actuator cover.

Abstract: A variable pump for an internal combustion engine incudes a drive wheel, a drive shaft configured to be driven via the drive wheel, a coupling pump impeller comprising pump blades, a coupling turbine wheel comprising turbine blades arranged axially opposite to the pump blades, and an impeller which is fixedly connected with the coupling turbine wheel. The coupling pump impeller is arranged to be rotationally fixed on the drive shaft. The coupling turbine wheel is configured to rotate on the drive shaft. The coupling pump impeller is arranged so as to be axially displaceable with respect to the coupling turbine wheel.

Abstract: A stator includes a stator stack comprising stator poles, a groove arranged between each of the stator poles, and a coil winding comprising a winding end arranged on each of the stator poles. The winding ends comprise cophasal coil windings and non-cophasal coil windings. A guiding body comprises an axial surface arranged opposite to the stator stack, a wall extending perpendicular to a central axis of the stator stack, and guiding body contours. Connecting bodies connect the cophasal coil windings with each other. Each of the connecting bodies comprises a connecting body contour. The connecting body contours engage with the corresponding guiding body contours. Isolating bodies electrically isolate the non-cophasal coil windings from each other. The winding ends extend at a common axial end of the stator beyond the stator stack into the guiding body.

Abstract: A spring arrangement for a variable valve drive of an internal combustion engine includes an intermediate lever, a control shaft, a control shaft roller, a working cam contour, and a spring element. The intermediate lever comprises a contact surface, a camshaft roller which bears against a camshaft, and a slot roller which bears against a slotted guide. The control shaft roller is arranged on the intermediate lever to face away from the slotted guide. The control shaft roller bears against the control shaft. The working cam contour is formed at an end of the intermediate lever opposite the camshaft roller. The spring element comprises a force component on the contact surface in the direction of the camshaft and the slotted guide, and an end leg. The spring element loads the camshaft roller against the camshaft and the slot roller against the slotted guide. The end leg bears against the contact surface.

Abstract: A mechanically controllable valve drive arrangement includes gas exchange valves each having cylinders associated therewith, a camshaft comprising a peripheral contour, a bearing, an adjusting lever comprising a first end and a second end, a valve lift adjustment device comprising a control shaft which acts on the first end, and a transmission arrangement associated with a respective gas exchange valve. The adjusting lever is supported in the bearing. Each transmission arrangement comprises at least one intermediate lever arrangement comprising an engagement element, and an intermediate lever comprising a working cam, and at least one pivot lever arrangement comprising a pivot lever. The working cam is operatively connected to the pivot lever. The intermediate lever is operatively connected to the peripheral contour. The engagement element is operatively connected to the valve lift adjustment device. The second end of the adjusting lever is operatively connected to the engagement element.

Abstract: A valve train assembly for an engine comprising cylinders, each comprising a gas inlet and a gas outlet valve. A camshaft comprises a peripheral contour. A valve stroke adjusting device comprises a control shaft comprising control contours. An intermediate lever arrangement comprises an intermediate lever comprising a working curve which cooperates with a swivel lever, and an engagement element connected to a control contour. Each intermediate lever is connected to the peripheral contour. A transmission arrangement provides that an intermediate lever arrangement and a swivel lever arrangement is associated with each gas inlet valve. A control contour for an idle range is similar to a control contour for a full-load range. A control contour for a part-load range of a gas inlet valve of a shut-off cylinder comprises a section different to a control contour for a part-load range of the gas inlet valve of a remaining cylinder.

Abstract: An intermediate lever arrangement for a mechanically-controllable valve drive arrangement, includes a pivot lever arrangement. At least one intermediate lever(s) comprising a working cam is configured to be in an operative connection with the pivot lever arrangement. A bearing shaft is arranged on the at least one intermediate lever(s). An engagement element comprising a circumferential point is mounted in the at least one intermediate lever(s) arrangement so as to rotate about an axis of rotation. A fixing device is arranged on the bearing shaft. The fixing device is configured to fix the engagement element in a defined position. A device is configured so that the circumferential point of the engagement element, upon a rotation by an angle ?, describes a curved shape which deviates from an arc of a circle.

Abstract: A mechanically controllable valve-train assembly includes a plurality of gas exchange valves, at least two cylinders assigned to each of the gas exchange valves, and valve-lift adjusting devices which each comprise a rotatable eccentric shaft. The eccentric shaft comprises at least one cam element and circumferential control surfaces which comprise at least one eccentric member. The eccentric shaft is driven by a drive device to set various valve-lift positions. A transmission assembly assigned to each of the gas exchange valves is mounted in a cylinder head via a bearing device so as to be movable and is operatively connected to one of the valve-lift adjusting devices and to a camshaft. The at least one cam element is operatively connected to a spring-loaded tappet element and is arranged outside the circumferential control surfaces and at a level of a zero-lift position of the circumferential control surfaces.

Abstract: A valve unit includes a positioning device for converting a rotary motion into a linear motion, a valve rod, a drive unit, a drive shaft with an eccentric arranged thereon, a coupling element comprising a slot, and an output shaft arranged at the eccentric which moves in the slot of the coupling element. The valve rod is connected with the coupling element. The valve rod is linearly movable with the coupling element between an initial position where the valve is closed and an end position. The slot comprises a guide path which cooperates with the eccentric having an angle with a plane perpendicular to a direction of movement of the adjusting element. The initial position of the eccentric is a position which is located before a dead center existing for an axial movement of the output shaft. The dead center is passed during a rotational movement of the drive shaft.

Abstract: A valve device for an internal combustion engine includes a multi-part housing. A drive unit generates a rotational moment. The drive unit is arranged in a motor chamber. A transmission unit is arranged in a transmission chamber. An eccentric is configured to be driven by the transmission unit. A valve rod is configured to be displaceable in translation. The valve rod extends into a valve rod displacement chamber. A coupling element converts a displacement of the eccentric into a translational displacement of the valve rod. A valve seat is arranged between an inlet and an outlet. A valve closing body is attached to the valve rod. The valve closing body is configured to be lowered onto the valve seat and lifted off the valve seat. A cover is disposed between the eccentric and the coupling element. The cover is configured to separate the transmission chamber from the valve rod displacement chamber.