Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

Abstract: A water-resistant orthopedic undercast sleeve that includes a tubular sheet material formed of extruded filaments having water-resistant properties and a thickness sufficient to provide both cushioning and moisture transport in a single layer between a cast and a limb onto which the sleeve is applied. The water resistant properties are achieved by at least one process, including a water-resistant filler, finish or coating applied to the filaments during extrusion, applying a water resistant finish to the finish during extrusion, applying a water resistant finish to the filaments during a subsequent spinning process, or coating the filaments with a water-resistant finish in a separate process. Moisture egress channels are formed in the sheet material for transporting moisture away from the limb, longitudinally along the length of the sleeve, and out of the space between the sleeve and cast.

Abstract: A low density fabric substrate for a medical bandaging product. The substrate has a plurality of longitudinally-extending voids formed in the fabric for permitting water penetration through the fabric thickness from one of the major faces to the other major faces. A reactive system is impregnated into or coated onto the substrate and remains stable when maintained in substantially moisture-free conditions and hardens upon exposure to sufficient moisture to form a rigid, self supporting structure. A soft, flexible protective material covers at least one of the major faces of the substrate along its length to provide a cushioning barrier between the substrate and the skin of a patient when the material is in use.

Abstract: A medical bandaging product, including a non-woven, fibrous, flexible medical material adapted for being applied and conformed to a body part to be supported, and a reactive system impregnated into or coated onto the medical material. The system remains stable when maintained in a non-activated condition in the absence of an activating agent, such as water, and hardens upon activation by exposure to the activating agent to form a rigid, self supporting structure. An enclosure is provided within which the medical material is maintained against exposure to the activating agent until use. The product may be in pre-cut shapes or in roll-form for cutting off a desired length for a given use.

Abstract: A method of dispensing and resealing a moisture curable medical material against moisture intrusion is provided. The method includes the steps of providing a moisture-impervious product container comprising an elongate sleeve sealable to prevent entry of moisture, providing an elongate medical material positioned in the sleeve, sealing the medical material in the sleeve against entry of moisture until use, providing a dispensing carton within which the sleeve and medical material positioned therein is contained, and bearing a tab against the length of the sleeve devoid of medical material and into a laterally-extending opening in the sealing member to form a doubled thickness of the sleeve having a sealing fold therein to form a seal that is resistant to moisture intrusion into the sleeve.

Abstract: A medical bandaging product, including a sleeve formed of moisture-impervious material and sealable to prevent entry of moisture, and a medical material positioned in the sleeve and sealed therein against entry of moisture until use. The medical material is a substrate having two marginal areas of relatively lower modulus yarns and/or a more open knitted structure to provide reduced abrasion against the skin. A reactive system on the substrate remains stable when maintained in substantially moisture-free conditions and hardens upon exposure to sufficient moisture to form a rigid, self supporting structure. A soft, flexible protective material covers at least one of the major faces of the substrate along its length to provide a cushioning barrier between the substrate and the skin of a patient when the material is in use.

Abstract: A medical bandaging product that includes a container formed of moisture-impervious material, a medical material positioned in the container in substantially moisture-free conditions and sealed therein against entry of moisture, and a dispensing carton within which the container and medical material positioned therein is contained. The dispensing carton includes an opening in the carton through which the medical material is removed through an opening in the container, and an S-shaped sealing member carried by the carton adjacent the opening for receiving across the opening in the carton a length of the container devoid of medical material A tab bears against the length of the container devoid of medical material to form a doubled thickness of the container having a sealing fold therein to form a seal that is resistant to moisture intrusion into the container.

Abstract: A medical bandaging product, including a sleeve formed of moisture-impervious material and sealable to prevent entry of moisture, and a medical material positioned in the sleeve and sealed therein against entry of moisture until use. The medical material is a substrate having two marginal areas of relatively lower modulus yarns and/or a more open knitted structure to provide reduced abrasion against the skin. A reactive system on the substrate remains stable when maintained in substantially moisture-free conditions and hardens upon exposure to sufficient moisture to form a rigid, self supporting structure. A soft, flexible protective material covers at least one of the major faces of the substrate along its length to provide a cushioning barrier between the substrate and the skin of a patient when the material is in use.

Abstract: A medical bandaging product fabricated of a rib-knitted fabric constructed of synthetic yarns selected from the group of acrylic, polyester and polypropylene yarns. An elastic yarn provides elasticity to the fabric, and an effective amount of a water repelling treatment is applied to the fabric for imparting water-repellent characteristics. The fabric may be used as a cast liner or as a protective wrapping of a splint product.

Abstract: A medical bandaging product, including a sleeve formed of moisture-impervious material and sealable to prevent entry of moisture, and a medical material positioned in the sleeve and sealed therein against entry of moisture until use. The medical material is a substrate having two marginal areas of relatively lower modulus yarns and/or a more open knitted structure to provide reduced abrasion against the skin. A reactive system on the substrate remains stable when maintained in substantially moisture-free conditions and hardens upon exposure to sufficient moisture to form a rigid, self supporting structure. A soft, flexible protective material covers at least one of the major faces of the substrate along its length to provide a cushioning barrier between the substrate and the skin of a patient when the material is in use.

Abstract: A medical bandaging product, including a non-woven, fibrous, flexible medical material adapted for being applied and conformed to a body part to be supported, and a reactive system impregnated into or coated onto the medical material. The system remains stable when maintained in a non-activated condition in the absence of an activating agent, such as water, and hardens upon activation by exposure to the activating agent to form a rigid, self supporting structure. An enclosure is provided within which the medical material is maintained against exposure to the activating agent until use. The product may be in pre-cut shapes or in roll-form for cutting off a desired length for a given use.

Abstract: A method of dispensing and resealing a moisture curable medical material against moisture intrusion is provided. The method includes the steps of providing a moisture-impervious product container comprising an elongate sleeve sealable to prevent entry of moisture, providing an elongate medical material positioned in the sleeve, sealing the medical material in the sleeve against entry of moisture until use, providing a dispensing carton within which the sleeve and medical material positioned therein is contained, and bearing a tab against the length of the sleeve devoid of medical material and into a laterally-extending opening in the sealing member to form a doubled thickness of the sleeve having a sealing fold therein to form a seal that is resistant to moisture intrusion into the sleeve.

Abstract: A water-resistant orthopedic undercast sleeve that includes a tubular sheet material formed of extruded filaments having water-resistant properties and a thickness sufficient to provide both cushioning and moisture transport in a single layer between a cast and a limb onto which the sleeve is applied. The water resistant properties are achieved by at least one process, including a water-resistant filler, finish or coating applied to the filaments during extrusion, applying a water resistant finish to the finish during extrusion, applying a water resistant finish to the filaments during a subsequent spinning process, or coating the filaments with a water-resistant finish in a separate process. Moisture egress channels are formed in the sheet material for transporting moisture away from the limb, longitudinally along the length of the sleeve, and out of the space between the sleeve and cast.

Abstract: A medical bandaging product that includes a container formed of moisture-impervious material, a medical material positioned in the container in substantially moisture-free conditions and sealed therein against entry of moisture, and a dispensing carton within which the container and medical material positioned therein is contained. The dispensing carton includes an opening in the carton through which the medical material is removed through an opening in the container, and an S-shaped sealing member carried by the carton adjacent the opening for receiving across the opening in the carton a length of the container devoid of medical material A tab bears against the length of the container devoid of medical material to form a doubled thickness of the container having a sealing fold therein to form a seal that is resistant to moisture intrusion into the container.

Abstract: A low density fabric substrate for a medical bandaging product. The substrate has a plurality of longitudinally-extending voids formed in the fabric for permitting water penetration through the fabric thickness from one of the major faces to the other major faces. A reactive system is impregnated into or coated onto the substrate and remains stable when maintained in substantially moisture-free conditions and hardens upon exposure to sufficient moisture to form a rigid, self supporting structure. A soft, flexible protective material covers at least one of the major faces of the substrate along its length to provide a cushioning barrier between the substrate and the skin of a patient when the material is in use.

Abstract: A medical bandaging product, including a sleeve formed of moisture-impervious material and sealable to prevent entry of moisture, and a medical material positioned in the sleeve and sealed therein against entry of moisture until use. The medical material is a substrate having two marginal areas of relatively lower modulus yarns and/or a more open knitted structure to provide reduced abrasion against the skin. A reactive system on the substrate remains stable when maintained in substantially moisture-free conditions and hardens upon exposure to sufficient moisture to form a rigid, self supporting structure. A soft, flexible protective material covers at least one of the major faces of the substrate along its length to provide a cushioning barrier between the substrate and the skin of a patient when the material is in use.

Abstract: A medical bandaging product fabricated of a rib-knitted fabric constructed of synthetic yarns selected from the group of acrylic, polyester and polypropylene yarns. An elastic yarn provides elasticity to the fabric, and an effective amount of a water repelling treatment is applied to the fabric for imparting water-repellent characteristics. The fabric may be used as a cast liner or as a protective wrapping of a splint product.

Abstract: An ankle brace of the type adapted to extend along the lateral and medial aspects of an injured ankle and lower leg for supporting the ankle during healing. A medial and lateral side support are provided for extending along the respective medial lateral aspects of the ankle and lower leg and includes an elongate, rigid support members, each having a lower end of sufficiently narrow width and thinness to fit inside a shoe being worn by a wearer of the brace, A soft, flexible perimeter edge portion is mechanically adhered to and extends outwardly in overlapping, non-interfitting relation to the support members for protecting the leg and ankle from irritation resulting from contact with edges of the support members. A connector connects the medial side support and lateral side support together at their respective lower ends and extend under the foot of the wearer of the brace.

Abstract: An orthopedic splint utilizing a polyurethane-based chemical system encapsulated in an envelope that hardens to form a splint. The orthopedic splint includes an envelope for containing a first component and a second component of maintained separate from each other within the envelope. A hardened splint is formed by causing the first component and the second component to mix in the envelope.

Abstract: An ankle brace of the type adapted to extend along the lateral and medial aspects of an injured ankle and lower leg for supporting the ankle during healing. A medial and lateral side support are provided for extending along the respective medial lateral aspects of the ankle and lower leg and includes an elongate, rigid support members, each having a lower end of sufficiently narrow width and thinness to fit inside a shoe being worn by a wearer of the brace, A soft, flexible perimeter edge portion is mechanically adhered to and extends outwardly in overlapping, non-interfitting relation to the support members for protecting the leg and ankle from irritation resulting from contact with edges of the support members. A connector connects the medial side support and lateral side support together at their respective lower ends and extend under the foot of the wearer of the brace.