Abstract: The invention provides polyfluorinated aromatic or heterocyclic compounds comprising at least three ring substituents, at least one of which comprises a sulfurpentafluoride group and at least one of which comprises a labile group; methods for their preparation are also disclosed. Preferably, the compounds comprise either two sulfurpentafluoride groups or one sulfurpentafluoride group and one other polyfluorinated group, such as a trifluoromethyl group. Said labile group preferably comprises an amino, bromo or nitro group. Said compounds are useful in the preparation of medicaments.

Abstract: The invention provides polyflurinated aromatic or heterocyclic compounds comprising at least three ring sustitutents, at least one of which comprises a sulphurpentafluoride group and at least one of which comprises a labile group; methods for their preparation are also disclosed. Preferably, the compounds comprise either two sulphurpentafluoride groups or one sulphurpentafluoride group and one other polyflurinated group, such as a trifluoromethyl group. Said labile group preferably comprises an amino, bromo or nitro group. Said compounds are useful in the preparation of medicaments.

Abstract: A process is provided for the fluorination of an aromatic fused ring compound which comprises treating the compound with fluorine. A preferred process involves treating a solution of a naphthalene compound in an inert solvent with elemental fluorine, preferably comprised in a gas stream and diluted with an inert gas. The process provides a convenient and simple method by which fluorinated derivatives may be prepared with a high degree of specificity and shows improved yields over methods known from the prior art.