Abstract: Medical devices for ablating nerves perivascularly and methods for making and using the same are disclosed. An example medical device may include an expandable frame slidably disposed within a catheter shaft. The expandable frame may be configured to shift between a collapsed configuration and an expanded configuration. One or more electrodes may be disposed on a surface of the expandable frame. The one or more electrodes may be disposed radially inward relative to the greatest radial extent of the expandable frame when the expandable frame is in the expanded configuration.

Abstract: A seed assembly for delivery to an interior of a heart includes an electrical stimulation circuit for delivering an electrical stimulus to cardiac tissue. A first electrode assembly is mechanically and electrically coupled to the seed assembly via a micro lead the first electrode assembly configured to deliver the electrical stimulus generated by the electrical stimulation circuit to the cardiac tissue. The seed assembly and the first electrode assembly are sized and shaped to fit entirely within the heart.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include an elongate shaft including a first tubular member and a second tubular member. A balloon may be coupled to the shaft. A first member may be coupled to the first tubular member and positioned within the balloon. A second member may be coupled to the first tubular member and positioned within the balloon. A medical implant may be coupled to the shaft and positioned adjacent to the balloon.

Abstract: Some embodiments of pacing systems employ wireless electrode assemblies to provide pacing therapy. The wireless electrode assemblies may wirelessly receive energy via an inductive coupling so as to provide electrical stimulation to the surrounding heart tissue. In certain embodiments, the wireless electrode assembly may include one or more biased tines that shift from a first position to a second position to secure the wireless electrode assembly into the inner wall of the heart chamber.

Abstract: An implantable cardiac tissue excitation system includes an implantable pacing controller unit with a pulse generation circuit. The system also includes a lead with a lead body extending between a proximal lead end attachable to the pacing controller unit and a distal lead end configured to be implanted within a heart. A lead conductor extends within the lead body. The system also includes a transmitter assembly located near the distal lead end that is electrically connected to the pulse generation circuit through the lead conductor to wirelessly transmit pacing control information and pacing energy. The system also includes a leadless electrode assembly configured to be implanted within the heart that includes a receiver to receive the wireless transmission, a charge storage unit to store the charge energy, and an electrical stimulation circuit to deliver an electrical stimulus to cardiac tissue using the pacing control information and the charge energy.

Abstract: Systems for nerve and tissue modulation are disclosed. An example system may an elongate shaft including an expandable frame coupled to the shaft adjacent to a distal end of the shaft. The frame may include a plurality of electrically conductive regions for emitting an electrical current comprising at least a first electrically conductive region and a second electrically conductive region. The system may further include a ground pad and a control unit electrically coupled to the plurality of electrically conductive regions and the ground pad. The control and power unit is configured to operate in unipolar mode and bipolar mode during the same procedure.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a renal nerve modulation device. The renal nerve modulation device may include an elongate shaft. A balloon may be coupled to the shaft. The balloon may have a hydrophilic electrode region. A sensor may be coupled to the balloon and may be disposed adjacent to the hydrophilic electrode region. An electrode may be coupled to the catheter shaft and may be disposed within the balloon.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a system for nerve modulation. The system may include an elongate shaft and a nerve modulation assembly disposed at the distal end of the shaft. The nerve modulation assembly may have a collapsed configuration and an expanded configuration. The nerve modulation assembly may include an inner basket and an outer basket. The inner basket may include a plurality of electrode struts. Each electrode strut may include an electrode. The outer basket may include a plurality of spacer struts.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include an elongate shaft including a first tubular member and a second tubular member. A balloon may be coupled to the shaft. A first member may be coupled to the first tubular member and positioned within the balloon. A second member may be coupled to the first tubular member and positioned within the balloon. A medical implant may be coupled to the shaft and positioned adjacent to the balloon.

Abstract: Some embodiments of a cardiac stimulation system may include a plurality of electrode assemblies that are interconnected by one or more wires while at least one of the electrode assemblies (e.g., a control electrode) wirelessly receives energy through inductive coupling with a power communication unit external to the heart (e.g., a device implanted along one or more ribs). These embodiments may provide an arrangement for efficient inductive coupling from the power communication unit to the control electrode. Also, in some circumstances, the cardiac stimulation system may eliminate the need for wired leads that extend to a location outside the heart, thereby reducing the likelihood of infection that passes along the wire and into the heart.

Abstract: An apparatus and method can receive wireless energy using a wireless electrostimulation electrode assembly. In certain examples, at least some of the received wireless energy can be delivered as an electrostimulation to a heart. In certain examples, the wireless electrostimulation electrode can be mechanically supported at least partially using a ring formed by an annulus of a mitral valve of the heart. In certain examples, the wireless electrostimulation electrode assembly can be configured to be intravascularly delivered to an implant location within a chamber of the heart at the annulus of the mitral valve of the heart, and can fit entirely within the heart.

Abstract: A catheter includes a flexible braided shaft having a length sufficient to access a target vessel of the body, such as a renal artery. An electrode at the catheter's distal tip is configured to ablate extravascular target tissue, such as perivascular renal nerve tissue. An electrical conductor coupled to the electrode extends along a first lumen of the shaft. A second lumen of the shaft terminates at a port arrangement on an outer surface of the shaft near the electrode. The second lumen transports a contrast media from the catheter's proximal end and through the port arrangement. The catheter may include a steering arrangement and a lubricious coating on an outer surface of the shaft, allowing a clinician to navigate the catheter through vasculature and into the target vessel without use of a separate delivery sheath or guiding catheter.

Abstract: A catheter arrangement includes a flexible shaft and a balloon disposed at a distal end of the shaft and configurable for deployment within a target vessel of the body, such as a renal artery. Ablation electrodes, supported by a balloon wall, are arranged in a predefined pattern. The electrodes deliver electrical energy sufficient to ablate target tissue, such as perivascular renal nerves, proximate the target vessel wall when the balloon is in a deployed configuration. A cooling arrangement is encompassed at least in part by the balloon and provides cooling to at least the electrodes during ablation such that a location at which steady-state ablative heating begins is translated from an electrode-tissue interface at the target vessel wall to a location a predetermined distance away from the electrode-tissue interface.

Abstract: A system/assembly for delivery and deployment of an inflation expandable stent within a vessel, comprising a catheter having proximal and distal ends; a stent, inflation expandable from a delivery diameter to a deployment diameter, such that the delivery diameter is reduced from the deployment diameter for conforming the stent to the catheter, such that the stent, in its delivery diameter, is coaxially mounted on the catheter near the catheter distal end; an expandable inflation means coaxially mounted on the catheter axially within the stent, for expansion of the stent from the delivery diameter to the deployment diameter upon application of fluid deployment pressure to the inflation means; and a securement component coaxially mounted on the catheter, axially within the expandable inflation means, the securement component designed and adapted to provide a securement pressure to the stent in the delivery diameter to maintain the stent in position on the catheter during delivery to the deployment site.

Abstract: An illustrative balloon catheter is disclosed. The balloon catheter may include an elongate shaft including a proximal section, a midshaft section, and a distal section. In some embodiments, the midshaft section may include a braid encapsulated in a polymer material. Additionally or alternatively, the midshaft section may include a thermoset polymer material. Additionally, in some cases, the distal section may include a distal outer tubular member and a distal inner tubular member, one or more of which may include a polymer material and, in some cases, a braid. Additionally, some example proximal section may include a metal polymer composite material.

Abstract: A system/assembly for delivery and deployment of an inflation expandable stent within a vessel, comprising a catheter having proximal and distal ends; a stent, inflation expandable from a delivery diameter to a deployment diameter, such that the delivery diameter is reduced from the deployment diameter for conforming the stent to the catheter, such that the stent, in its delivery diameter, is coaxially mounted on the catheter near the catheter distal end; an expandable inflation means coaxially mounted on the catheter axially within the stent, for expansion of the stent from the delivery diameter to the deployment diameter upon application of fluid deployment pressure to the inflation means; and a securement component coaxially mounted on the catheter, axially within the expandable inflation means, the securement component designed and adapted to provide a securement pressure to the stent in the delivery diameter to maintain the stent in position on the catheter during delivery to the deployment site.

Abstract: An apparatus and method can receive wireless energy using a wireless electrostimulation electrode assembly. In certain examples, at least some of the received wireless energy can be delivered as an electrostimulation to a heart. In certain examples, the wireless electrostimulation electrode can be mechanically supported at least partially using a ring formed by an annulus of a mitral valve of the heart. In certain examples, the wireless electrostimulation electrode assembly can be configured to be intravascularly delivered to an implant location within a chamber of the heart at the annulus of the mitral valve of the heart, and can fit entirely within the heart.

Abstract: Closure devices with a rapidly dissolving anchor, systems delivering closure devices, and methods for making and using the same. An example closure device for closing an opening in a body lumen may include a plug, a rapidly dissolving anchor, and a suture coupling the plug to the anchor. The rapidly dissolving anchor may be configured to dissolve within the body lumen within about 30 days or less. At least a portion of the plug may be disposed adjacent an exterior surface of the body lumen. At least a portion of the rapidly dissolving anchor may be disposed within the body lumen.

Abstract: A medical device comprises a catheter having at least one catheter shaft, which defines an inflation lumen for transport of an inflation fluid therethrough. The inflation fluid comprises a coolant. An expandable balloon, which has a proximal cone, distal cone, and a body region therebetween, is engaged to a distal region of the at least one catheter shaft. The balloon interior is in fluid communication with the inflation lumen. A portion of the catheter distal of the balloon body defines at least one port that is in fluid communication with the inflation lumen and the balloon interior.

Abstract: An implantable cardiac tissue excitation system includes an implantable pacing controller unit with a pulse generation circuit. The system also includes a lead with a lead body extending between a proximal lead end attachable to the pacing controller unit and a distal lead end configured to be implanted within a heart. A lead conductor extends within the lead body. The system also includes a transmitter assembly located near the distal lead end that is electrically connected to the pulse generation circuit through the lead conductor to wirelessly transmit pacing control information and pacing energy. The system also includes a leadless electrode assembly configured to be implanted within the heart that includes a receiver to receive the wireless transmission, a charge storage unit to store the charge energy, and an electrical stimulation circuit to deliver an electrical stimulus to cardiac tissue using the pacing control information and the charge energy.