Abstract: The present invention relates to a compound according to Formula (1a) or (1b): wherein R1; R3; Y and X are defined herein, and their use in methods of nucleic acid synthesis.

Abstract: A method, system, and computer program product are disclosed for securely orchestrating containers in a container orchestration environment. The containers comprise confidential containers running in a trusted execution environment (TEE) and standard containers running in the container orchestration environment. The containers are securely orchestrated without modifying the containers, container runtimes, and platforms, protecting sensitive data and code of the containers by restricting access to containers.

Abstract: Disclosed herein are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.

Abstract: Methods and systems are provided to generate instructions and share video content following an impact event. They include detecting an impact event associated with a vehicle and transmitting a request to at least one video recording device within an area of interest from the vehicle. They further include receiving video content captured within a time period around the impact event from at least one video recording device. Methods and systems are also provided to generate useful information following an impact event including detecting an impact event associated with a vehicle and determining one or more contextual parameters associated with the impact event. They further include generating display content based on the one or more contextual parameters and displaying the generated display content on a screen within the vehicle.

Abstract: The invention relates to a hair styling device, and in particular to a hair straightener. The hair styling device (10; 210) has a first arm (12; 212) and a second arm (14; 214), the first and second arms being moveable relative to one another between a closed or operative condition and an open or inoperative condition. The first member (12; 212) has a first heating panel (16; 116; 216) and the second member (14; 214) has a second heating panel (18; 118; 218). The heating panels (16, 18; 116, 118; 216, 218) are corrugated to increase the length of the path the hair must take between the heating panels. The first and second heating panels are spaced apart in the operative condition so as not to press or clamp the hair therebetween.

Abstract: An adapter includes a substantially rigid body having a distal portion, a proximal portion, a central opening formed at least in part by an inner wall of the body, and a longitudinal axis extending substantially centrally through the opening. The distal portion includes an annular ring having a top surface and a ridge disposed opposite the top surface, the ridge extending substantially perpendicular to the longitudinal axis. The distal. The adapter also includes a seal configured to form a substantially fluid-tight seal with a surface of a fitting removably attachable to the adapter.

Abstract: A terrain-referenced navigation system for an aircraft comprises: a stored digital terrain map; a position calculation unit arranged to calculate aircraft position relative to the stored digital terrain map to determine a terrain-referenced aircraft position; a fall line calculation unit arranged to calculate a fall line for a projectile starting from the terrain-referenced aircraft position as a launch point; and an impact point calculation unit arranged to directly compare the fall line with the digital terrain map, by incrementally comparing a height of the projectile along the fall line with a height of the terrain according to the stored digital terrain map in order to find an expected impact point on the terrain.

Abstract: Among other things, the present disclosure provides various agents. In some embodiments, provided agents can bind to beta-catenin. In some embodiments, the present disclosure provides technologies for modulating beta-catenin functions. In some embodiments, the present disclosure provides technologies for preventing and/or treating conditions, disorders or diseases associated with beta-catenin. In some embodiments, the present disclosure provides designed amino acids which can provide improved properties and/or activities. In some embodiments, the present disclosure provides agents comprising such amino acids.

Abstract: The present invention relates to a cleaning implement that includes a melamine-formaldehyde foam. The melamine-formaldehyde foam includes from about 0.1 to about 5 weight % of at least one linear polymer with a number average molecular weight Mn in the range from 500 to 10,000 g/mol. Additionally the present invention encompasses processes for making and methods for cleaning hard surfaces with a cleaning implement according to the present invention.

Abstract: A hinge assembly includes a first hinged body, a pivot pin assembly, and a second hinged body. The first hinged body includes a channel. The pivot pin assembly includes a pin body configured to slideably engage the channel. The pivot pin assembly may be translated within the channel and adjustably secured along the channel. The pin body includes a downwardly extending pin. The second hinged body comprises a pin aperture configured to cooperatively receive the pin. The first hinged body and the second hinged body are configured to hingedly pivot along a hinge axis defined by the pin when the pin is received in the pin aperture. The pin body may include a pin body aperture configured to receive an alignment fastener such that the pin body may be tilt adjusted relative to the first hinged body.

Abstract: A method of determining ageing of a mixed electrode of a full cell lithium ion battery is presented. The method includes obtaining a voltage hysteresis of the full cell lithium ion battery by comparison of a charging voltage to a discharging voltage at a specific state of charge, SOC. The specific SOC is in a range from 0% to 20% of a maximum SOC. The method further includes determining ageing of a volume expanding component of the mixed electrode based on the obtained voltage hysteresis.

Abstract: A bioconjugate of an E. coli glucosylated O4 antigen polysaccharide covalently linked to a carrier protein and compositions thereof are provided. Also provided are recombinant host cells for producing the bioconjugate, and methods of producing the bioconjugate using the recombinant host cells. The recombinant host cells contain a nucleic acid encoding a glucosyl transferase capable of modifying the E. coli O4 antigen with glucose branching to produce the glucosylated O4 antigen polysaccharide. Bioconjugates of an E. coli glucosylated O4 antigen polysaccharide described herein can be used alone or in combination with one or more additional E. coli O-antigen polysaccharides to induce antibodies against an E. coli glucosylated antigen, and to vaccinate a subject against extra-intestinal pathogenic E. coli (ExPEC).

Abstract: An electronic user device includes inclusion list storage with electronically readable memory, for storing an inclusion list and the inclusion list indicating included logical IDs. The device also has a security module app that receives a cellular broadcast message and extracts logical IDs therefrom. This processes a targeted cellular broadcast message embedded in the payload of the cellular broadcast message, based on whether a logical ID, also embedded in the payload, of the targeted cellular broadcast message is on the inclusion list. It then formats it for consumption by an electronic user device app that receives data via a data channel when available.

Abstract: Disclosed herein an anti-pT217 Tau antibody or a pT217 Tau-binding fragment thereof.

Abstract: Various embodiments provide systems and methods for live action gaming. According to one embodiment, a method facilitates scoring for an in-person, live-action game, for example, a projectile-tag scoring game or the like, involving multiple players. A gaming outfit worn by a first player or a projectile launcher of a second player may determine a shot hit by the second player against the first player based at least in part on detection of an impact of a projectile fired by the projectile launcher with the gaming outfit. A score for the in-person, live-action game may then be updated based on the shot hit.

Abstract: An active rear diffuser for a rear portion of a vehicle. The rear diffuser assembly is formed from a set of components that are uniform across all vehicle platforms, with some of the components being scalable and allowing them to be adjusted to an appropriate length without any retooling.

Abstract: In some embodiments, the present disclosure provides stapled peptides and compositions thereof. In some embodiments, provided peptides can bind to and modulate functions of estrogen receptor.

Abstract: The present invention relates to aqueous polymer latexes of film-forming copolymers which are suitable as binders in waterborne coating compositions, and are obtainable by aqueous emulsion polymerisation of ethylenically unsaturated monomers M, which comprise •20 to 95% by weight, based on the total amount of monomers M, of at least one monomer M1, which is selected from isobutyl acrylate and isoamyl acrylate and mixtures thereof; •0 to 55% by weight, based on the total amount of monomers M, of at least one monomer M2, which is selected from ethyl acrylate, n-propyl acrylate, n-butyl acrylate, n-pentyl acrylate, C6-C20-alkyl esters of acrylic acid and C5-C20-alkyl esters of methacrylic acid and mixtures thereof; •5 to 50% by weight, based on the total amount of monomers M, of at least one monomer M3, which is selected from tert-butyl acrylate, C1-C4-alkyl esters of methacrylic acid, C5-C20-cycloalkyl esters of acrylic acid, C5-C20-cycloalkyl esters of methacrylic acid, C5-C20-cycloalkylmethyl esters of acryli

Abstract: This invention generally provides two tactile stimulation modules, or “tappers”. One tapper is held by a person in each of his hands. Alternatively, a tapper is secured to each wrist or to other parts of the body on opposite sides. Each tapper is powered by a rechargeable battery, and contains both a tactile stimulation transducer, such as an electric motor having either a balanced or unbalanced mass on its output shaft, and a transceiver that communicates with a host or master. Each tapper includes at least one control button and a status indicator. Each tapper contains a micro-controller that performs tasks such as communication, motor activation, user monitoring and control, battery monitoring, low-power sleep, and algorithm execution. At least one tapper can contain at least one optional sensor, which measures a physiological function. Measurements can be used to modify performance of the tactile stimulation transducers.