Abstract: The invention provides arylthioether acetamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as bacterial infections, and in inhibiting LpxA activity.

Abstract: An III-nitride power semiconductor based heterojunction device comprising a first heterojunction and a second heterojunction transistor, wherein the second heterojunction transistor has a substantially identical structure to the first heterojunction transistor, and wherein the second heterojunction transistor is scaled to a smaller area or gate perimeter than the first heterojunction transistor by a scale factor X, where X is larger than 1.

Abstract: Systems and methods can determine respiratory rates of a patient using a respiratory device by performing one or more frequency analyses of a signal from the gases flow. The signal from the gases flow can be one that varies with the patient's breathing. The system can include a non-sealed patient interface, such as a nasal cannula in a nasal high flow therapy, or any other patient interfaces. The respiratory system can also detect whether the patient has taken off the patient interface and/or whether the patient connected to the patient interface is talking or eating. Data of the patient's use of the respiratory system and the patient's respiratory rates can provide therapy compliance and long-term trend of use information and/or progress in the patient's respiratory functions and/or other physiological functions.

Abstract: Various embodiments of a vortex hybrid motor are described herein. In some embodiments, the vortex hybrid motor may include a housing with a solid propellant positioned within the housing, and an injector ring positioned at a proximal end of the housing. The injector ring can include a plurality of angled injector units each including a first injector and a second injector angled towards an impingement point. A first fluid stream of a liquid propellant dispensed from the first injector can collide with a second fluid stream of the liquid propellant dispensed from the second injector to atomize the liquid propellant and form a spray fan formation. At least one of the first injector and the second injector can be positioned at an injection angle relative to the sidewall to create a swirl flow of the atomized injector fluid.

Abstract: A neutron reflector design which lowers stress in inner reflector members by supporting the inner reflector members on radially adjacent outer reflector members at the interface between the inner and outer reflector members, such that an individual inner reflector member is not supported by an inner reflector member in a layer of the reflector assembly immediately below, and the inner reflector member does not have to bear a load from an inner reflector member in a layer of the reflector assembly immediately above. The lowering of the load carried by the individual inner reflector members with this individual-member-support arrangement reduces stress-induced reflector damage with is enhanced in the high radiation flux environment adjacent to a nuclear reactor core. The inner reflector members are removable for replacement without the need to remove the outer reflector members.

Abstract: A runtime application self protection (RASP) plug-in logic monitors for, and prevents, outbound network connections that are initiated by server application logic and that are not intended by the application logic. The RASP plug-in has access to information generally available only to the application logic and identifies specific vulnerabilities within the application logic that can be patched. The vulnerabilities are identified by (i) data identifying the portion(s) of the application logic that is the source of the vulnerability and (ii) data identifying the authenticated user, if any, that is the source of the attack. The RASP plug-in catches and identifies specific attacks on the application logic in real-world, production operation.

Abstract: The VOIP call security is enhanced using the caller's geographical location information, which is transmitted to the home network device using an unmodifiable header. The home network device checks the veracity of the caller's geographical location information to determine whether the caller is suspicious.

Abstract: Systems and methods are provided for maintaining data privacy in a communication system. The method includes: providing a proxy network which creates a plurality of ingress processing elements and a plurality of egress processing elements, wherein the ingress processing elements and the egress processing elements each include at least a private processing unit and a private memory area; receiving a request at a selected ingress processing element from a first server; routing the request from the selected ingress processing element to a selected egress processing element; forwarding the request from the selected egress processing element to a second server; and erasing both the selected ingress processing element and the selected egress processing element.

Abstract: The invention provides a particle comprising a first semiconductor and a second semiconductor wherein the first semiconductor forms a heterojunction with the second semiconductor. The invention also provides a pharmaceutical composition comprising the particles, and relates to uses of the particles and composition in the treatment of cancer in combination with radiotherapy.

Abstract: A runtime application self protection (RASP) plug-in logic monitors for, and prevents, outbound network connections that are initiated by server application logic and that are not intended by the application logic. The RASP plug-in has access to information generally available only to the application logic and identifies specific vulnerabilities within the application logic that can be patched. The vulnerabilities are identified by (i) data identifying the portion(s) of the application logic that is the source of the vulnerability and (ii) data identifying the authenticated user, if any, that is the source of the attack. The RASP plug-in catches and identifies specific attacks on the application logic in real-world, production operation.

Abstract: The VOIP call security is enhanced using the caller's geographical location information, which is transmitted to the home network device using an unmodifiable header. The home network device checks the veracity of the caller's geographical location information to determine whether the caller is suspicious.

Abstract: A sintered polycrystalline body and a method of forming the sintered polycrystalline body are disclosed. The sintered polycrystalline body comprises a plurality of particles cubic boron nitride dispersed in a matrix. The matrix includes materials selected from compounds of any of titanium and aluminium. The polycrystalline body further comprises 0.1 to 5.0 volume % of lubricating chalcogenide particles dispersed in the matrix. The chalcogenide particles have a coefficient of friction of less than 0.1 with respect to a workpiece material. Preferably sulfide particles are used as lubricant. Preferably 30-70 vol.-% cBN is contained. Sintering takes place at 1100-1600° C. and 4-8 GPa.

Abstract: A sintered polycrystalline body and a method of forming the sintered polycrystalline body are disclosed. The sintered polycrystalline body comprises a plurality of particles cubic boron nitride dispersed in a matrix. The matrix includes materials selected from compounds of any of titanium and aluminium. The polycrystalline body further comprises 0.1 to 5.0 volume % of lubricating chalcogenide particles dispersed in the matrix. The chalcogenide particles have a coefficient of friction of less than 0.1 with respect to a workpiece material. Preferably sulfide particles are used as lubricant. Preferably 30-70 vol.-% cBN is contained. Sintering takes place at 1100-1600° C. and 4-8 GPa.

Abstract: A sense amplifier is provided. The sense amplifier comprises a first and second cross-coupled transistor pairs, a first and second current sources, a first digital input transistor, and a second digital input transistor. The first and second ends of the first cross-coupled transistor pair are coupled to an operating voltage, the first and second back gate ends of the first cross-coupled transistor pair are coupled to a first and second output ends respectively. The first and second back gate ends of the first cross-coupled transistor pair are coupled to a first and second output ends respectively, and the first and second ends of the first cross-coupled transistor pair are coupled to a first digital input end and second digital input end respectively.

Abstract: A method of screening compounds or molecules comprising the steps of: translating a sequence encoding the amino acid sequence comprising SEQ ID No. 29 in a translation system in the presence of a test compound or molecule; and analysing the translation product(s) for the presence of one or more of (a) a peptide comprising the amino acids Pro-Gly at the C terminus and a peptide comprising the amino acid Pro at the N terminus: or (b) a peptide comprising the amino acid sequence of SEQ ID No. 29.

Abstract: An improved gas delivery system and method delivers a sequence of pulses of prescribed amounts of at least two gases to a process chamber of a process tool in accordance with a predetermined recipe of steps of a gas delivery process. The system comprises: a plurality of channels, each including a control valve connected so as to control each pulse of gas flowing through the corresponding channel into the process chamber of the process tool; and an exhaust valve for controlling the pressure within the process chamber, the exhaust valve including a valve controller for controlling the operation of the gas delivery system including the control valves and the exhaust valve in accordance with the predetermined recipe of steps.

Abstract: An optical coating, comprising porous particles, or formed from porous precursor particles. The average thickness of the coating is in the range of from 75 to 400 nm, and the surface roughness of the coating is in the range of from 2 to 300 nm. This coating provides broadband antireflective properties across the visible and near infrared part of the electromagnetic spectrum.

Abstract: A method of screening compounds or molecules comprising the steps of: translating a sequence encoding the amino acid sequence comprising SEQ ID No. 29 in a translation system in the presence of a test compound or molecule; and analysing the translation product(s) for the presence of one or more of (a) a peptide comprising the amino acids Pro-Gly at the C terminus and a peptide comprising the amino acid Pro at the N terminus: or (b) a peptide comprising the amino acid sequence of SEQ ID No. 29.

Abstract: A master valve and at least one slave valve are connected via a network, wherein upon broadcast of a position setpoint of the master valve the at least one slave valve achieves a corresponding position within a shortened period of time, such network being a dedicated network or high speed shared network with position setpoint priority.

Abstract: A master valve and at least one slave valve are connected via a network, wherein upon broadcast of a position setpoint of the master valve the at least one slave valve achieves a corresponding position within a shortened period of time, such network being a dedicated network or high speed shared network with position setpoint priority.