Abstract: The present invention relates to bispecific anti-CCL2 antibodies binding to two different epitopes on human CCL2, pharmaceutical compositions thereof, their manufacture, and use as medicaments for the treatment of cancers, inflammatory, autoimmune and ophthalmologic diseases.

Abstract: The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of prostate cancer. Thus, the present invention concerns compounds that are represented by the general Formulae (Ia) or (Ib).

Abstract: The present invention relates to a compound or a pharmaceutically acceptable salt thereof having a chemical structure comprising: (A) at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; and (C) at least one dye moiety; wherein said compound has a molecular weight of not more than 5 kDa. Further, the invention refers to a method for producing such compound and to the in vivo and in vitro uses thereof.

Abstract: A rotary pressure filter, comprising a filter drum and a housing. A sensor is attached to the housing and emits light through a light-permeable section of the housing in the direction of a filter cake. The sensor receives light reflected from the filter cake through the light-permeable section of the housing. A processing unit compares properties of the emitted light with those of the received light and determines an absolute thickness of the filter cake and/or a change in the thickness of the filter cake over a pre-determined time. The invention further relates to a corresponding method.

Abstract: This disclosure relates to a compressor having at least two compression stages. In particular, an exemplary compressor includes a first radial compression stage arranged along an axis, a second radial compression stage arranged along the axis, and a connector fluidly connecting an outlet of the first radial compression stage to an inlet of the second radial compression stage. The connector has a plurality of sections arranged about the axis. The compressor may be a refrigerant compressor used in a heating, ventilation, and air conditioning (HVAC) chiller system.

Abstract: The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers and imaging agents for various disease states of prostate cancer.

Abstract: The present invention relates to a compound or a pharmaceutically acceptable salt thereof having a chemical structure comprising: A compound or a pharmaceutically acceptable salt thereof of formula (I): (A)-x1-(B)-x2-(C), wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; x1 is a spacer covalently connecting (A) and (B); x2 is a spacer or a chemical single bond connecting (B) and (C); wherein (C) has the formula wherein R1 to R4, R9, a, b, Y and X1 to X4 have the meaning as indicated in the claims and description.

Abstract: The present invention relates to a compound of a pharmaceutically acceptable salt thereof of formula (I) wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; x1 is a spacer or a chemical single bond covalently connecting (A) to the rest of the molecule; x2 is a spacer or a chemical single bond covalently connecting (C) to the rest of the molecule. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition.

Abstract: The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers and imaging agents for various disease states of prostate cancer.

Abstract: A multifunction operating device includes a carrier; an input part which has an input surface comprising an array of operating surfaces and which is to be mounted so as to be able to move relatively to the carrier; a touch sensor system which is designed to detect a touching of the input surface by an operating member of an operator, which touching is spatially resolved on the different operating surfaces, and to provide it as a touch detection result; a control unit electrically connected to the touch sensor system; an actuator electrically connected to the control unit and having an effective direction (W) for driving the input part so as to move it relatively to the carrier in order to generate an active haptic; the control unit is designed to trigger the active haptic depending on the touch detection result; an electromechanical switching element electrically connected to the control unit and arranged between the input part and the carrier in order to detect an actuation exerting a minimum actuating force

Abstract: A method for operating an internal combustion engine. The method includes: operating the internal combustion engine including a lambda regulation, which sets a fuel quantity to be supplied in accordance with a predefined setpoint lambda value, at preset times, carrying out a filter cleaning operation for a fuel tank ventilation, as a function of the presence of a release condition of the internal combustion engine, carrying out an adaptation of the lambda regulation by adapting at least one adaptation parameter as a function of operating variables of the internal combustion engine, at active filter cleaning operation and upon the presence of the release condition, operating variables which are required to carry out the adaptation of the lambda regulation being recorded, at deactivated filter cleaning operation and presence of the release condition, the adaptation of the lambda regulation being carried out as a function of the recorded operating variables.

Abstract: The present disclosure relates to an electrical cable assembly with a connector, in particular a trunk line cable assembly for a photovoltaic system, and to an assembly consisting of a module inverter and the trunk line cable assembly connected thereto, and also relates to a photovoltaic system comprising a plurality of photovoltaic modules and module inverters and AC side cabling between the module inverters and the trunk line cable assemblies, wherein the drop lines are connected to the trunk line cable by means of the connector, wherein the junction is enclosed by a two-piece connector housing which includes strain relief means for the trunk line cable and is optionally additionally overmolded.

Abstract: An assembly of at least two members. One of the members supports the other member, the assembly defining an axial direction, a radial direction, and a circumferential direction, an inner member of the at least two members being received radially inside an outer member of the at least two members, wherein the inner member and the outer member am attached to each other by a support arrangement, the support arrangement including at least one floating support assembly as a displaceable coupling between an inner member support point provided at the inner member and an outer member support point provided at the outer member. A displacement of support points in a radial direction results in an interrelated relative displacement of the support points in an axial direction end vice versa.

Abstract: A refrigerant compressor according to an exemplary aspect of the present disclosure includes, among other things, an impeller arranged in a main flow path and including a plurality of vanes. The impeller is configured to rotate about an axis. A channel is outside the main flow path. A first orifice fluidly couples the channel to the main flow path upstream of the vanes, and a second orifice fluidly couples the channel to the main flow path downstream of leading edges of the vanes.

Abstract: A mirror, a mirror substrate, a method for producing are provided. The mirror substrate is made of a material having a coefficient of mean linear thermal expansion of less than or equal to 1*10?6/K. The mirror substrate includes at least one feature selected from a group consisting of: a ratio of a lateral dimension to a maximum thickness of at least 100, a ratio of the lateral dimension to the maximum thickness of at least 150, a ratio of the lateral dimension to the maximum thickness of at least 200, a ratio of the lateral dimension to the maximum thickness of at least 300, a weight per unit area of 100 kg/m2 or less, a weight per unit area of 50 kg/m2 or less, a weight per unit area of 30 kg/m2 or less, a weight per unit area of 15 kg/m2 or less, a mirror surface with a roughness (Ra) of at most 3.5 ?m, and a mirror surface with a roughness (Ra) of less than 1.2 ?m.

Abstract: A component is produced in layers by laser melting. A molten pool is created in a bed of powder by a working laser beam. Further auxiliary laser beams are set to a power density that merely slows down the cooling of the material in one zone, but do not cause any renewed melting. In this way, the cooling rate of the microstructure can be set so that an advantageous structural formation develops. This allows for example the mechanical properties of the component produced to be advantageously improved without downstream heat treatments.

Abstract: A device for the additive manufacturing of a shaped body comprising: a process chamber for a material for making the shaped body; a plurality of bar elements defining at least a partial region of the process chamber, wherein each of the plurality of bar elements is movable in relation to one another; and a sensor associated with at least one of the plurality of bar elements detecting forces and/or torques acting on the at least one bar element.

Abstract: The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of prostate cancer. Thus, the present invention concerns compounds that are represented by the general Formulae (Ia) or (Ib).

Abstract: The present invention relates to a compound or a pharmaceutically acceptable salt thereof having a chemical structure comprising: (A) at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; and (C) at least one dye moiety; wherein said compound has a molecular weight of not more than 5 kDa. Further, the invention refers to a method for producing such compound and to the in vivo and in vitro uses thereof.

Abstract: The present invention provides a sealing device for an opening. The device includes a body that has a first side and a second side. A passageway is formed through the body such that the passageway has a first end adjacent to the first side and a second end that is adjacent to the second side. A sealing member is provided that includes an outer gasket and an inner gasket. The outer gasket is positioned adjacent the first side and the inner gasket is positioned adjacent the second side. A seal connector connects the inner gasket and the outer gasket and the seal connector passes through the passageway. In this way, the inner gasket and the outer gasket are mechanically attached to the ring. The sealing device is configured for use in such applications as sealing the cargo opening on the deck of a kayak.