Abstract: dsRNAi oligonucleotides can be used in methods for the treatment of NASH, preferably the advanced fibrotic and/or cirrhotic stages thereof, using dosage regimens comprising a loading phase followed by a maintenance phase.

Abstract: An electrohydrodynamic inkjet printing system includes a print head with a plurality of ink nozzles arranged in recesses on the print head. A plurality of ejection electrodes located at the ink nozzles. A support structure is arranged in front of the ink nozzles and forming a front surface, wherein the ejection electrodes are arranged on the support structure. Gas from a first gas source and/or from a second gas source is conveyed through gas ducts and or gas is fed through the gas ducts to a gas sink. The gas ducts extend, over at least part of their length, along the support structure.

Abstract: A spectrometer device includes an optical interference filter which is designed to filter specific wavelength ranges of an incident light beam on passage through the optical interference filter. The spectrometer device also includes a detector device which is designed to detect the filtered light beam. Further, the spectrometer device includes a focusing device with a reflective surface. The focusing device is designed to focus the filtered light beam onto the detector device by reflection on the surface.

Abstract: A production cell includes: at least one robot arranged to handle products; at least one buffer area for intermediate storage of products inside the production cell; a vision system with cameras arranged to determine, based on images from the cameras, the identity and the location of objects in the production cell a plurality of production modules, each production module comprising at least one Hardware Module configured to process products; and a plurality of module attachment locations, each module attachment location being configured to connect with an interface section of a production module through at least a physical connection and a power connection.

Abstract: A method and apparatus for cooling a semiconductor chamber are described herein. A semiconductor chamber component, includes a powered region, a grounded region, and a fluid conduit disposed within the semiconductor chamber component and passing through the powered region and grounded region, the fluid conduit comprising a ceramic material.

Abstract: A spectrometer apparatus is disclosed that includes at least one light source for irradiating a sample with light, an optical detection device for detecting light scattered by the sample, at least one optical filter device, which is arranged in front of and/or behind the sample, a contact sensor device for determining a contact between the sample and the spectrometer apparatus and for outputting a corresponding output signal, a control device for controlling the light source and the detection device in response to the output signal. The control device is designed such that the control device modifies at least one operating parameter of the light source and the detection device, when the output signal indicates the contact between the sample and the spectrometer apparatus. A method for operating a spectrometer apparatus is disclosed as well.

Abstract: The invention relates to a mobile construction crane comprising a superstructure and an undercarriage, wherein one or more electrical consumers are provided in or at the superstructure, wherein a supply of the one or more electrical consumers with electrical energy takes place by at least one current generator installed in the undercarriage.

Abstract: System for order-receipt processing of an eyeglass lens, including: a receiver configured to receive order data of eyeglass lens, to store a catalog of eyeglass lens classes, which each are defined by a fixed number of predetermined and freely selectable order parameters and differ from each other in the number of freely selectable order parameters, and to classify the order data on the basis of the catalog of eyeglass lens classes, a processor configured to process the order data, to store only the highest eyeglass lens classes of the catalog of eyeglass lens classes, to select one of the highest eyeglass lens classes, to match the order data to the selected highest eyeglass lens class, to generate a respective digital reproduction of the eyeglass lens based on a calculation model and the adapted order data, and a communication device connecting the receiver and the processor.

Abstract: A valve assembly for a piston compressor, in particular an oil-free piston compressor for generating compressed air in a rail vehicle, includes a valve plate having a compressed-air opening, a valve retainer and a valve lamina which is flexible and/or movable in relation to the valve retainer and is provided for opening and closing the compressed-air opening; wherein a damping and/or braking device is provided which is associated with the valve lamina.

Abstract: The electrohydrodynamic print head comprises a nozzle carrier with a plurality of nozzles arranged thereon. A plurality of electrodes associated with the nozzles are located on the front side of the nozzles. A support structure supporting the electrodes is located on the nozzle carrier and comprises a plurality of support elements arranged between the nozzles. Ink retainers are arranged between the nozzles and the support elements. The front surfaces of the ink retainers are located behind the front ends of the nozzles in order to prevent the nozzles from being submerged by ink. Guard electrodes can be provided between the ejection electrodes and the ink retainers to reduce the electrical fields at the ink retainers and thereby to improve their efficiency to pin the ink. Suction ducts surrounding each nozzle allow to remove ink from the nozzles.

Abstract: The present invention relates to an improved treatment protocol using Intralymphatic immunotherapy (ILIT). In particular, the present invention relates ILIT in relation to grass allergy.

Abstract: A monitoring and measuring device for an air supply system of a vehicle, in particular a rail vehicle, includes a compressor which is designed to provide compressed air; a defined volume which is situated downstream of the compressor; a shut-off valve which is situated downstream of the defined volume; a pressure sensor which is provided at any desired position on the pressure line between the compressor and the shut-off valve and is configured to measure the pressure that builds in the defined volume. A first or second air drying device, for example, is used as the defined volume. The pressure curve measured by the pressure sensor can indicate whether there is a fault or a leak. A method for monitoring and for measuring parameters of an air supply system of a vehicle, in particular a rail vehicle is also provided.

Abstract: Container closure for a container (1), the container closure having at least one receiving chamber, for receiving a substance of liquid or powdery consistency, and having a mouthpiece (5) comprising a through-opening (13), characterized in that the container closure has an adapter (2), into which a capsule (3) having the substance is interchangeably inserted, and an actuating element (6) for actuating the capsule (3), wherein the capsule (3) has a housing forming the receiving chamber, in which a perforator (7) is arranged, and the housing has two openings, wherein one opening is closed by a closure film (8) and the second opening is closed by an end region of the perforator (7), wherein the actuating element (6) is operatively connected to the end region of the perforator (7) that closes the second opening of the capsule (3), and the adapter (2), the capsule (3) and the actuating element (6) form mutually separate components.

Abstract: A compressor system and method for operating a compressor system according to the compressed-air demand in an operating state of the vehicle utilize a compressor for producing compressed air for at least one compressed-air vessel, the delivery rate of the compressor being able to be adjusted at least indirectly by means of a control device. The control device is configured to be able to increase the delivery rate of the compressor beyond a defined operating maximum rate when there is exceptional demand.

Abstract: The invention relates to a compressor system for a rail vehicle, having: a compressor, a cooling device and a control device or an interface for receiving control signals of a control device, wherein the control device is configured to actuate the cooling device independently of the operation of the compressor, and to be able to provide a variable cooling fluid volumetric flow rate, in particular a cooling air volumetric flow rate, which can be specified by way of the control device as an actuating variable.

Abstract: The invention relates to an axle-mounted brake disk for a rail vehicle, comprising two friction rings which are arranged in parallel and at a distance from each other and are interconnected by a plurality of ribs extending in the direction of the rotational axis of the friction rings, where at least some of the ribs are embodied with different cross-sections from each other, where the cross-sections of a first subset of the ribs, embodied as supporting elements transmitting pressure forces, do not fall below a minimum cross-section, defined by the stability required in relation to the mechanical load during a brake process, and the cross-section of a second subset of the ribs, used to radiate thermal energy, falls below the minimum cross-section.

Abstract: A filter element has a filter medium annularly surrounding a longitudinal axis of the filter element. The filter medium can be flowed through radially from an exterior to an interior and has a plurality of folds. A first end disk is arranged at a first end face of the filter element. A primary air passage and a secondary air passage are provided. The filter medium has an axial recess at the first end face. The first end disk has a channel forming the secondary air passage and extending in the axial recess. The plurality of folds include first folds in a region of the recess and second folds away from the recess. An axial length of the first folds is reduced relative to an axial length of the second folds. An air filter with such filter element and an assembly method for the air filter are provided.

Abstract: An air filter has a filter housing having a raw air inlet and further has a filter element arranged in the filter housing. The filter element has a filter medium body and an end disk with a central primary air passage and a secondary air passage. The filter medium body annularly surrounds a longitudinal axis of the filter element and separates a raw side in the filter housing from a clean side inside the filter element. The filter housing has a primary air outlet communicating through the primary air passage with the clean side of the filter element. The filter housing has a secondary air outlet communicating through the secondary air passage with the clean side of the filter element. The secondary air outlet communicates with the secondary air passage through a channel arranged at the filter element, wherein the channel surrounds the primary air passage annularly and coaxially.

Abstract: A filter element has a filter medium folded in a star shape that surrounds annularly a longitudinal axis of the filter element and is flowed through radially from exterior to interior. The filter element has a primary air passage and a secondary air passage. In the filter medium, a cutout is formed that penetrates a plurality of folds of the filter medium. A passage socket at which the secondary air passage is formed extends through the cutout. An air filter provided with a filter housing having a raw air inlet, a primary air outlet, and a secondary air outlet, has such a filter element that separates in the filter housing a raw side communicating with the raw air inlet from a clean side. The primary air outlet communicates through the primary air passage and the secondary air outlet through the secondary air passage with the clean side, respectively.

Abstract: A method is described for charging an accumulator having terminals at which a terminal voltage is applied. The method includes the following steps: (a) charging the accumulator using a predefined current or a predefined electrical power until the terminal voltage has reached a predefined first value; (b) determining a time-dependent drop in the terminal voltage of the accumulator at a reduced charge current; (c) determining a second value on the basis of the voltage loss, the second value being greater than the first value; and (d) charging the accumulator using a predefined current or a predefined electrical power until the terminal voltage of the accumulator has reached the second value.