Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: A configuration for a key management system is provided for managing cryptographic keys in cryptosystems. The configuration includes the use of database replication to improve the reliability, accessibility, and partition tolerance of the key management system. The configuration also includes the use of database sharding and distributed networks to improve the functionality of the key management system. From a logical level, the system can appear multi-master because client software can connect with any compute node in a plurality of compute nodes and perform key management operations on the entire key database from that compute node. From a physical level, the system can be a master-slave configuration with each database shard replication group having a single master shard instance and one or more slave shard instances. In some examples, the present disclosure provides better redundancy, load balancing, availability, and partition tolerance for key management systems.

Abstract: A computerized authorization system configured to authorize electronically-made requests to an electronic entity. The computerized authorization system comprises a store configured to store an indication of at least one predetermined electronic authorization device configured to authorize each electronically-made request. The computerized authorization system is further configured such that: in response to receiving an electronically-made request to the electronic entity, an indication of the request is output to the at least one predetermined electronic authorization device configured to authorize the request as indicated in the store; and in response to receiving an indication of authorization from the at least one predetermined electronic authorization device, an indication of authorization of the request is output to the electronic entity.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: The present invention relates to an electrode assembly, electrode structures and an electrolyser using said assemblies/structures, and in particular provides an electrode assembly comprising an anode structure and a cathode structure, each of said anode structure and cathode structure comprising i) a flange which can interact with a flange on an another electrode structure to hold a separator in between the two, ii) an electrolysis compartment which contains an electrode, and which in use contains a liquid to be electrolysed, iii) an inlet for the liquid to be electrolysed and iv) an outlet header for evolved gas and spent liquid, wherein the outlet header on one of the anode structure and the cathode structure is an external outlet header and the outlet header on the other one of the anode structure and the cathode structure is an internal outlet header, as well as to electrolysers comprising a plurality of such electrode assemblies.

Abstract: This invention relates to gaskets, apparatus incorporating said gaskets and to methods of using them.

Abstract: The present invention relates to an electrode assembly and an electrolyser using said assemblies/structures, wherein the electrode assembly comprises an anode structure and a cathode structure, each of said anode structure and cathode structure comprising an outlet header for evolved gas and spent liquid, wherein each of said anode structure and cathode structure comprising an outlet header for evolved gas and spent liquid, wherein the outlet header on the anode structure has a total internal volume of VA cm3 and the outlet header on the cathode structure has a total volume of VC cm3 wherein VA is less than VC, and/or i) the outlet header on the anode structure has an internal volume, VA cm3, an internal cross sectional area at the exit end of the header of AA cm2 and an internal length LA cm, and ii) the outlet header on the cathode structure has an internal volume, VC cm3, an internal cross sectional area at the exit end of the header of AC cm2 and an internal length LC cm, and one or both of the ratios VA/

Abstract: A computerized authorization system configured to authorize electronically-made requests to an electronic entity. The computerized authorization system comprises a store configured to store an indication of at least one predetermined electronic authorization device configured to authorize each electronically-made request. The computerized authorization system is further configured such that: in response to receiving an electronically-made request to the electronic entity, an indication of the request is output to the at least one predetermined electronic authorization device configured to authorize the request as indicated in the store; and in response to receiving an indication of authorization from the at least one predetermined electronic authorization device, an indication of authorization of the request is output to the electronic entity.

Abstract: A configuration for a key management system is provided for managing cryptographic keys in cryptosystems. The configuration includes the use of database replication to improve the reliability, accessibility, and partition tolerance of the key management system. The configuration also includes the use of database sharding and distributed networks to improve the functionality of the key management system. From a logical level, the system can appear multi-master because client software can connect with any compute node in a plurality of compute nodes and perform key management operations on the entire key database from that compute node. From a physical level, the system can be a master-slave configuration with each database shard replication group having a single master shard instance and one or more slave shard instances. In some examples, the present disclosure provides better redundancy, load balancing, availability, and partition tolerance for key management systems.

Abstract: A method, system, and computer-program product for handling network partitions in a network is provided. For example, a method can include providing a first compute node and a second compute node on the network. In such an example, the first compute node can include a master instance of a cryptographic database. In addition, the second compute node can include a first synchronous slave instance associated with the master instance. The method can further include identifying a network partition event on the network. The method can further include providing an asynchronous slave instance associated with the master instance and changing the asynchronous slave instance to a second synchronous slave instance in response to identifying the network partition event.

Abstract: A configuration for a key management system is provided for managing cryptographic keys in cryptosystems. The configuration includes the use of database replication to improve the reliability, accessibility, and partition tolerance of the key management system. The configuration also includes the use of database sharding and distributed networks to improve the functionality of the key management system. From a logical level, the system can appear multi-master because client software can connect with any compute node in a plurality of compute nodes and perform key management operations on the entire key database from that compute node. From a physical level, the system can be a master-slave configuration with each database shard replication group having a single master shard instance and one or more slave shard instances. In some examples, the present disclosure provides better redundancy, load balancing, availability, and partition tolerance for key management systems.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: The present invention relates to an electrode assembly, electrode structures and an electrolyser using said assemblies/structures, and in particular provides an electrode assembly comprising an anode structure and a cathode structure, each of said anode structure and cathode structure comprising i) a flange which can interact with a flange on an another electrode structure to hold a separator in between the two, ii) an electrolysis compartment which contains an electrode, and which in use contains a liquid to be electrolysed, iii) an inlet for the liquid to be electrolysed and iv) an outlet header for evolved gas and spent liquid, wherein the outlet header on one of the anode structure and the cathode structure is an external outlet header and the outlet header on the other one of the anode structure and the cathode structure is an internal outlet header, as well as to electrolysers comprising a plurality of such electrode assemblies.

Abstract: The present invention relates to an electrode assembly and an electrolyser using said assemblies/structures, wherein the electrode assembly comprises an anode structure and a cathode structure, each of said anode structure and cathode structure comprising an outlet header for evolved gas and spent liquid, wherein each of said anode structure and cathode structure comprising an outlet header for evolved gas and spent liquid, wherein the outlet header on the anode structure has a total internal volume of VA cm3 and the outlet header on the cathode structure has a total volume of VC cm3 wherein VA is less than VC, and/or i) the outlet header on the anode structure has an internal volume, VA cm3, an internal cross sectional area at the exit end of the header of AA cm2 and an internal length LA cm, and ii) the outlet header on the cathode structure has an internal volume, VC cm3, an internal cross sectional area at the exit end of the header of AC cm2 and an internal length LC cm, and one or both of the ratios VA/

Abstract: A method, system, and computer-program product for handling network partitions in a network is provided. For example, a method can include providing a first compute node and a second compute node on the network. In such an example, the first compute node can include a master instance of a cryptographic database. In addition, the second compute node can include a first synchronous slave instance associated with the master instance. The method can further include identifying a network partition event on the network. The method can further include providing an asynchronous slave instance associated with the master instance and changing the asynchronous slave instance to a second synchronous slave instance in response to identifying the network partition event.

Abstract: A configuration for a key management system is provided for managing cryptographic keys in cryptosystems. The configuration includes the use of database replication to improve the reliability, accessibility, and partition tolerance of the key management system. The configuration also includes the use of database sharding and distributed networks to improve the functionality of the key management system. From a logical level, the system can appear multi-master because client software can connect with any compute node in a plurality of compute nodes and perform key management operations on the entire key database from that compute node. From a physical level, the system can be a master-slave configuration with each database shard replication group having a single master shard instance and one or more slave shard instances. In some examples, the present disclosure provides better redundancy, load balancing, availability, and partition tolerance for key management systems.

Abstract: Provided are systems and methods for employing remote forensics and data security services over public and private networks by obtaining full access to digital data from the non-transitory computer-readable media of geographically dispersed computing devices such that the entire physical or logical media from each device is fully accessible to one or more user computers over the network. This is achieved via WebSocket technology implemented in point-to-point connection configurations, WebSocket technology implemented in network based digital data software switch configurations, and in combinations thereof. Application of these systems and methods are generally employed for the purpose of conducting remote examinations and remediation efforts upon electronic data comprising non-transitory computer-readable media on a network accessible computing device.

Abstract: This invention relates to gaskets, apparatus incorporating said gaskets and to methods of using them.