Patents by Inventor Martin Stelzle
Martin Stelzle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210292707Abstract: The invention refers to a method for culturing cells in a substrate in which a chamber having at least one side wall, a bottom, and a top is formed, comprising introduction of cells into the chamber, tilting of the substrate such that the cells accumulate on a side wall of the chamber, and holding the substrate in the tilted orientation such that the cells form a three-dimensional cell aggregate.Type: ApplicationFiled: March 18, 2021Publication date: September 23, 2021Applicant: ibidi GmbHInventors: Zeno VON GUTTENBERG, Britta HAGMEYER, Simon WERNER, Christian SCHMEES, Michael PAWLAK, Martin STELZLE
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Publication number: 20200405535Abstract: A cooling pad (10) for medical or veterinary applications, the cooling pad comprising a first heat exchanger (20); a second heat exchanger (30), a heat transfer fluid; a piping system (40); and an integrated pump device (50) for the heat transfer fluid; wherein the first heat exchanger (20) and the second heat exchanger (30) have the heat transfer fluid flowing through them; wherein the piping system (40) fluidically connects the first heat exchanger and the second heat exchanger; wherein the pump device (50) is adapted to cause an exchange of the heat transfer fluid between the first heat exchanger and the second heat exchanger; wherein the cooling pad (10) comprises a hermetically sealed fluid circuit for the heat transfer fluid, the fluid circuit comprising the first heat exchanger (20), the second heat exchanger (30), the piping system (40) and the pump device (50). Further, a corresponding cooling device (60), cooling system (1) and corresponding method (200) are proposed.Type: ApplicationFiled: September 11, 2020Publication date: December 31, 2020Inventors: Martin Stelzle, Gorden Steve Link, Simon Werner, Britta Hagmeyer
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Publication number: 20150204763Abstract: A system for carrying out analyses on and/or with biological sample material present in a sample arrangement region of a microfluidic sample chip comprises a connector plate for receiving the sample chip and a control unit to which the connector plate is detachably connectable for exchange of fluids and electrical signals.Type: ApplicationFiled: January 29, 2015Publication date: July 23, 2015Inventors: Martin Stelzle, Julia Schuette, Werner Simon, Britta Hagmeyer, Massimo Kubon
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Patent number: 9034162Abstract: A microfluidic cell for the dielectrophoretic separation, accumulation, and/or lysis of polarizable bioparticles, including an interdigital electrode system composed of two electrode groups having interdigitated electrodes, and a micromixer having microchannels and microelevations. The interdigital electrode system and the micromixer are situated on the same side of the cell to improve the separation, accumulation, and/or lysis characteristics. Moreover, also described is a microfluidic system which includes such a microfluidic cell, and use thereof, and a method for separating, accumulating, and/or lysing polarizable bioparticles.Type: GrantFiled: August 10, 2010Date of Patent: May 19, 2015Assignee: ROBERT BOSCH GMBHInventors: Michael Stumber, Martina Daub, Jochen Rupp, Massimo Kubon, Peter Rothacher, Meike Moschallski, Martin Stelzle, Christian Dorrer
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Patent number: 8968543Abstract: The present invention provides an apparatus and a method to assemble organotypical tissues which can then be perfused and investigated under preferably physiological conditions.Type: GrantFiled: March 22, 2012Date of Patent: March 3, 2015Assignee: NMI Naturwissenschaftliches und Medizinisches Institut an der Universitaet TuebingenInventors: Martin Stelzle, Brigitte Angres, Massimo Kubon, Julia Schuette, Britta Hagmeyer, Felix Holzner
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Patent number: 8268152Abstract: A microfluidic system (12) for assembling and subsequently investigating complex cell arrangements has a three-dimensional microstructure (11) in which the cell culture is assembled, cultivated and investigated. At least two microchannel segments (16, 17) through which the microstructure (11) can be perfused from outside with a medium (21, 22) run in the microstructure (11), whereby the microchannel segments (16, 17) run at least in sections approximately parallel or equidistant to one another. The two microchannel segments (16, 17) are separated from one another by a wall structure (25) in which at least one aperture (26) connecting the two microchannel segments (16, 17) is provided. An electrode arrangement (27) is provided in or on the microstructure (11) in order to generate an inhomogeneous electric field (28) in the region of the at least one aperture (26).Type: GrantFiled: October 1, 2010Date of Patent: September 18, 2012Assignee: NMI Naturwissenschaftliches und Medizinisches Institut an der Universitaet TuebingenInventors: Martin Stelzle, Brigitte Angres, Massimo Kubon, Julia Schuette, Britta Hagmeyer, Felix Holzner
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Publication number: 20120199487Abstract: The present invention provides an apparatus and a method to assemble organotypical tissues which can then be perfused and investigated under preferably physiological conditions.Type: ApplicationFiled: March 22, 2012Publication date: August 9, 2012Applicant: NMI Naturwissenschaftliches und Medizinisches Institute an der Universitaet TuebingenInventors: Martin STELZLE, Brigitte Angres, Massimo Kubon, Julia Schuette, Britta Hagmeyer, Felix Holzner
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Publication number: 20120183990Abstract: A closed microfluidic system is equipped with a carrier plate and a cover plate as well as wall regions arranged therebetween, which form a system of channels and/or cavities with an inner surface. Selected regions of the inner surface are selectively functionalized.Type: ApplicationFiled: February 27, 2012Publication date: July 19, 2012Inventors: Julia Schuette, Martin Stelzle
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Publication number: 20120031759Abstract: A dielectrophoretic fractionation device having a channel defining a direction of flow therethrough for the fractionation of particles in a liquid particle suspension is disclosed. The device also has a deflector unit affixed to a wall of the channel and arranged to generate an electric field gradient in the channel to spatially separate the particles in the liquid particle suspension. The device also has an actuator mounted to the channel and positioned to deform the wall. Also provided is a method for inhibiting aggregation of particles in a liquid particle suspension of the dielectrophoretic fractionation device, the method including periodically deforming the wall with the actuator.Type: ApplicationFiled: January 30, 2009Publication date: February 9, 2012Applicants: Natural and Medical Sciences Institute at the University of Tubingen, Bio-Rad Laboratories, Inc.Inventors: Monika Hausmann, Meike Moschallski, Anton Posch, Martin Stelzle, Joerg Kentsch, Simon Werner
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Publication number: 20110139621Abstract: A microfluidic cell for the dielectrophoretic separation, accumulation, and/or lysis of polarizable bioparticles, including an interdigital electrode system composed of two electrode groups having interdigitated electrodes, a flat electrode in which the interdigital electrode system and the flat electrode are situated on opposite sides of the cell in order to improve the separation, accumulation and/or lysis characteristics. Moreover, a microfluidic system which includes such a microfluidic cell, and use thereof, and a method for separating, accumulating, and/or lysing polarizable bioparticles is also described.Type: ApplicationFiled: August 10, 2010Publication date: June 16, 2011Inventors: Michael Stumber, Martina Daub, Jochen Rupp, Massimo Kubon, Peter Rothacher, Meike Moschallski, Martin Stelzle, Christian Dorrer
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Publication number: 20110139620Abstract: A microfluidic cell for the dielectrophoretic separation, accumulation, and/or lysis of polarizable bioparticles, including an interdigital electrode system composed of two electrode groups having interdigitated electrodes, and a micromixer having microchannels and microelevations. The interdigital electrode system and the micromixer are situated on the same side of the cell to improve the separation, accumulation, and/or lysis characteristics. Moreover, also described is a microfluidic system which includes such a microfluidic cell, and use thereof, and a method for separating, accumulating, and/or lysing polarizable bioparticles.Type: ApplicationFiled: August 10, 2010Publication date: June 16, 2011Inventors: Michael STUMBER, Martina Daub, Jochen Rupp, Massimo Kubon, Peter Rothacher, Meike Moschallski, Martin Stelzle, Christian Dorrer
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Publication number: 20110079513Abstract: A microfluidic system (12) for assembling and subsequently investigating complex cell arrangements has a three-dimensional microstructure (11) in which the cell culture is assembled, cultivated and investigated. At least two microchannel segments (16, 17) through which the microstructure (11) can be perfused from outside with a medium (21, 22) run in the microstructure (11), whereby the microchannel segments (16, 17) run at least in sections approximately parallel or equidistant to one another. The two microchannel segments (16, 17) are separated from one another by a wall structure (25) in which at least one aperture (26) connecting the two microchannel segments (16, 17) is provided. An electrode arrangement (27) is provided in or on the microstructure (11) in order to generate an inhomogeneous electric field (28) in the region of the at least one aperture (26).Type: ApplicationFiled: October 1, 2010Publication date: April 7, 2011Inventors: Martin Stelzle, Brigitte Angres, Massimo Kubon, Julia Schuette, Britta Hagmeyer, Felix Holzner
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Patent number: 7879214Abstract: A description is given of methods for collecting particles (1, 2) which are suspended in a liquid, including the following steps: providing the liquid containing the suspended particles (1, 2) in a compartment (10) having lateral surfaces (11), wherein at least one electrode (21) is arranged on at least one of the lateral surfaces (11), and generating high-frequency electric fields by means of the at least one electrode (21) so as to form at least one circulating flow (30), by means of which the particles (1, 2) are guided to at least one predetermined collecting area (40) in the compartment (10), wherein the flow (30) is formed in such a way that at least one branch of the flow runs along a longitudinal extent of the at least one electrode (21), and the flow (30) circulates about an axis (31) which is oriented perpendicular to the respectively adjacent lateral surface (11) with the electrode (21). Corresponding devices for collecting particles are also described.Type: GrantFiled: May 6, 2005Date of Patent: February 1, 2011Assignee: Perkinelmer Cellular Technologies Germany GmbHInventors: Thomas Schnelle, Torsten Muller, Jorg Kentsch, Frank Grom, Martin Stelzle
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Patent number: 7751896Abstract: An active retina implant has a multiplicity of pixel elements that convert incident light into electric stimulation signals for cells of the retina with which stimulation electrodes are to make contact. Each pixel element is provided with at least one image cell that converts incident light into electric signals, there being provided at least one amplifier whose input is connected to the image cell and whose output is connected to at least one stimulation electrode to which it supplies a stimulation signal. Also provided is an energy supply which provides externally coupled external energy as supply voltage for the image cells and the amplifiers. The image cell has a logarithmic characteristic according to which incident light of specific intensity is converted into electric signals of specific amplitude. The stimulation signal is supplied in the form of analog voltage pulses of specific pulse length and pulse spacings, the pulse amplitude being a function of the intensity of the incident light.Type: GrantFiled: December 19, 2005Date of Patent: July 6, 2010Assignee: Retina Implant AGInventors: Heinz-Gerhard Graf, Alexander Dollberg, Bernd Hoefflinger, Wilfried Nisch, Hugo Haemmerle, Alfred Stett, Martin Stelzle, Eberhart Zrenner
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Publication number: 20100084267Abstract: A pair of measuring electrodes comprising a first and a second, preferably in each case sheet-like electrode comprises an insulation layer arranged between said electrodes. One or more nanopores, which extend through said insulation layer as far as said first electrode, the surface of which is at least partially uncovered by said nanopores, are provided in each second electrode. The invention also describes a biosensor comprising a pair of measuring electrodes of this type, an electrochemical cell comprising a biosensor of this type and a process for producing said pair of measuring electrodes.Type: ApplicationFiled: September 25, 2009Publication date: April 8, 2010Applicant: NMI NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAT TEUBINInventors: Martin Stelzle, Wilfried Nisch
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Publication number: 20090194415Abstract: A pair of measuring electrodes comprising a first and a second, preferably in each case sheet-like electrode comprises an insulation layer arranged between said electrodes. One or more nanopores, which extend through said insulation layer as far as said first electrode, the surface of which is at least partially uncovered by said nanopores, are provided in each second electrode. The invention also describes a biosensor comprising a pair of measuring electrodes of this type, an electrochemical cell comprising a biosensor of this type and a process for producing said pair of measuring electrodes.Type: ApplicationFiled: January 27, 2009Publication date: August 6, 2009Applicant: NMI NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAT TUEBINInventors: Martin Stelzle, Wilfried Nisch
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Patent number: 7481912Abstract: A pair of measuring electrodes comprising a first and a second, preferably in each case sheet-like electrode comprises an insulation layer arranged between said electrodes. One or more nanopores, which extend through said insulation layer as far as said first electrode, the surface of which is at least partially uncovered by said nanopores, are provided in each second electrode. The invention also describes a biosensor comprising a pair of measuring electrodes of this type, an electrochemical cell comprising a biosensor of this type and a process for producing said pair of measuring electrodes.Type: GrantFiled: October 16, 2003Date of Patent: January 27, 2009Assignee: NMI Naturwissenschaftliches und Medizinisches Institut an der Universität TuebingenInventors: Martin Stelzle, Wilfried Nisch
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Publication number: 20070221501Abstract: A description is given of methods for collecting particles (1, 2) which are suspended in a liquid, including the following steps: providing the liquid containing the suspended particles (1, 2) in a compartment (10) having lateral surfaces (11), wherein at least one electrode (21) is arranged on at least one of the lateral surfaces (11), and generating high-frequency electric fields by means of the at least one electrode (21) so as to form at least one circulating flow (30), by means of which the particles (1, 2) are guided to at least one predetermined collecting area (40) in the compartment (10), wherein the flow (30) is formed in such a way that at least one branch of the flow runs along a longitudinal extent of the at least one electrode (21), and the flow (30) circulates about an axis (31) which is oriented perpendicular to the respectively adjacent lateral surface (11) with the electrode (21). Corresponding devices for collecting particles are also described.Type: ApplicationFiled: May 6, 2005Publication date: September 27, 2007Applicant: EVOTEC TECHNOLOGIES GMBHInventors: Thomas Schnelle, Torsten Muller, Jorg Kentsch, Frank Grom, Martin Stelzle
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Patent number: 7272447Abstract: An electrode arrangement for electrical stimulation of biological material has at least one stimulation electrode via which the biological material can be fed a stimulus signal. Furthermore, a counter electrode is present which forms a counter pole to the stimulation electrode, one sensor electrode is provided with the aid of which it is possible to determine a polarization voltage across the stimulation electrode.Type: GrantFiled: April 15, 2004Date of Patent: September 18, 2007Assignee: Retina Implant GmbHInventors: Alfred Stett, Wilfried Nisch, Martin Stelzle, Eberhart Zrenner
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Publication number: 20060184245Abstract: An active retina implant has a multiplicity of pixel elements that convert incident light into electric stimulation signals for cells of the retina with which stimulation electrodes are to make contact. Each pixel element is provided with at least one image cell that converts incident light into electric signals, there being provided at least one amplifier whose input is connected to the image cell and whose output is connected to at least one stimulation electrode to which it supplies a stimulation signal. Also provided is an energy supply which provides externally coupled external energy as supply voltage for the image cells and the amplifiers. The image cell has a logarithmic characteristic according to which incident light of specific intensity is converted into electric signals of specific amplitude. The stimulation signal is supplied in the form of analog voltage pulses of specific pulse length and pulse spacings, the pulse amplitude being a function of the intensity of the incident light.Type: ApplicationFiled: December 19, 2005Publication date: August 17, 2006Inventors: Heinz-Gerhard Graf, Alexander Dollberg, Bernd Hoefflinger, Wilfried Nisch, Hugo Haemmerle, Alfred Stett, Martin Stelzle, Eberhart Zrenner