Patents by Inventor Martin Stockmann

Martin Stockmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9560989
    Abstract: A method for determining the metabolic capacity of an enzyme includes time-resolved determination of the concentration of a product in exhaled air. The product is created by metabolism of a substrate, previously administered to an individual, by an enzyme of the individual. The product concentration is determined until the maximum product concentration in the exhaled air is reached. A model function is fitted to measured values of the product concentration, obtained by the time-resolved determination of the product concentration between start and end times. The metabolic capacity of the enzyme is determined based on parameters of the model function. Determining the metabolic capacity of the enzyme takes place based on at least two parameters of the model function, wherein the maximum value and time constant of the model function are not selected as parameters at the same time, and the start and/or end times are not selected as parameters.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: February 7, 2017
    Assignee: HUMEDICS GMBH
    Inventors: Karsten Heyne, Martin Stockmann, Tom Rubin
  • Patent number: 9278145
    Abstract: An analysis method determines a functional parameter of an organ by measuring 13CO2 content in exhaled air of an individual to which a substrate has been administered. The reaction of the substrate in the body of the individual enriches the exhaled air with 13CO2. The maximum reaction rate of the substrate in the body is determined via a change of the measured 13CO2 content in the exhaled air using zero-order enzyme kinetics. An aqueous methacetin solution having a pH greater than 7.0 is used in the analysis method. A face mask separates the exhaled air from inhaled air. The face mask is configured such that inhaled and exhaled air flows essentially completely through the face mask. Exhalation and inhalation valves in the face mask allow a flow of inhaled and exhaled air through the face mask. A diagnostic method is used to determine the functional parameters of the organ.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: March 8, 2016
    Assignees: FREIE UNIVERSITÄT BERLIN, CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN
    Inventors: Martin Stockmann, Björn Riecke
  • Publication number: 20150079619
    Abstract: An analysis method determines a functional parameter of an organ by measuring 13CO2 content in exhaled air of an individual to which a substrate has been administered. The reaction of the substrate in the body of the individual enriches the exhaled air with 13CO2. The maximum reaction rate of the substrate in the body is determined via a change of the measured 13CO2 content in the exhaled air using zero-order enzyme kinetics. An aqueous methacetin solution having a pH greater than 7.0 is used in the analysis method. A face mask separates the exhaled air from inhaled air. The face mask is configured such that inhaled and exhaled air flows essentially completely through the face mask. Exhalation and inhalation valves in the face mask allow a flow of inhaled and exhaled air through the face mask. A diagnostic method is used to determine the functional parameters of the organ.
    Type: Application
    Filed: November 25, 2014
    Publication date: March 19, 2015
    Inventors: Martin STOCKMANN, Björn RIECKE
  • Patent number: 8920334
    Abstract: The invention relates to an analysis method for determining a functional parameter of an organ of a human or animal individual by measuring the 13CO2 content in the air exhaled by the individual to which a substrate has been administered the reaction of which in the body of the individual enriches the air exhaled by the individual with 13CO2. The method is characterized by using a measuring device, the maximum reaction rate of the substrate in the body of the individual being determined via a change of the measured 13CO2 content in the air exhaled by the individual using zero-order enzyme kinetics. The invention also relates to an aqueous methacetin solution for use in said analysis method, the pH of the solution being greater 7.0. The invention also relates to a face mask (1) for use in the inventive method for separating the exhaled air from the air inhaled by an individual. Said face mask comprises a face mask body (2) and an air cushion (3) encircling the face mask body.
    Type: Grant
    Filed: June 26, 2006
    Date of Patent: December 30, 2014
    Assignees: Freie Universitaet Berlin, Charité Universitaetmedizin Berlin
    Inventors: Martin Stockmann, Bjön Riecke
  • Publication number: 20140107516
    Abstract: A method for determining the metabolic capacity of an enzyme includes time-resolved determination of the concentration of a product in exhaled air. The product is created by metabolism of a substrate, previously administered to an individual, by an enzyme of the individual. The product concentration is determined until the maximum product concentration in the exhaled air is reached. A model function is fitted to measured values of the product concentration, obtained by the time-resolved determination of the product concentration between start and end times. The metabolic capacity of the enzyme is determined based on parameters of the model function. Determining the metabolic capacity of the enzyme takes place based on at least two parameters of the model function, wherein the maximum value and time constant of the model function are not selected as parameters at the same time, and the start and/or end times are not selected as parameters.
    Type: Application
    Filed: April 13, 2012
    Publication date: April 17, 2014
    Applicant: HUMEDICS GMBH
    Inventors: Karsten Heyne, Martin Stockmann, Tom Rubin
  • Publication number: 20100143880
    Abstract: The invention relates to an analysis method for determining a functional parameter of an organ of a human or animal individual by measuring the 13CO2 content in the air exhaled by the individual to which a substrate has been administered the reaction of which in the body of the individual enriches the air exhaled by the individual with 13CO2. The method is characterized by using a measuring device, the maximum reaction rate of the substrate in the body of the individual being determined via a change of the measured 13CO2 content in the air exhaled by the individual using zero-order enzyme kinetics. The invention also relates to an aqueous methacetin solution for use in said analysis method, the pH of the solution being greater 7.0. The invention also relates to a face mask (1) for use in the inventive method for separating the exhaled air from the air inhaled by an individual. Said face mask comprises a face mask body (2) and an air cushion (3) encircling the face mask body.
    Type: Application
    Filed: June 26, 2006
    Publication date: June 10, 2010
    Applicants: FREIE UNIVERSITÄT BERLIN, CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN
    Inventors: Martin Stockmann, Björn Riecke
  • Publication number: 20090124918
    Abstract: The invention relates to an apparatus for spectroscopically analysing a gas, said apparatus having at least one radiation source (1), at least one detection apparatus (12; 20), at least one sample chamber (13) and a system of optical elements (4; 5; 6; 7; 9; 10; 11; 18; 19) which is intended and set up to direct at least part (3b) of the radiation (3) emitted by the radiation source (1) through the sample chamber (13) onto the detection apparatus (20), wherein the sample chamber (13) is used to hold a gaseous sample which contains the gas to be analysed, and wherein the apparatus is configured in such a manner that the sample can continuously flow through the sample chamber (13), and means (16) are provided for the purpose of determining the pressure and/or the volume and/or the concentration of the sample in the sample chamber (13). The invention also relates to a corresponding method for spectroscopically analysing a gas.
    Type: Application
    Filed: March 16, 2007
    Publication date: May 14, 2009
    Applicants: Freie Universitaetsmedizin Berlin,, Charite Universitaetsmedizin Berlin,
    Inventors: Martin Stockmann, Karsten Heyne, Bjoern Riecke
  • Patent number: D689603
    Type: Grant
    Filed: October 4, 2011
    Date of Patent: September 10, 2013
    Assignee: Humedics GmbH
    Inventor: Martin Stockmann