Abstract: Provided are compounds of Formula (I?): or pharmaceutically acceptable salts thereof, wherein the variables in the formula are as defined herein; and methods for their use and production.

Abstract: An apparatus and method for joining layers of a web of film in a sealing machine by using magnetic force generated by one or more electro-magnets. The apparatus includes a first member and a second member that are opposite to each other. The first member includes at least one electro-magnet. The second member includes a portion thereof that is attracted to the first member. A heater and a pressure applicator are coupled to one of the first or second members. The electro-magnet is energized and moves the second member towards the first member by attracting the second member. The first member and the second member urge together while the pressure applicator forces the film layers against the heating element to heat the layers. The pressure of the first and second members joins the softened layers together and thereby seals a portion of the layers of a web of film between the first member and second members.

Abstract: Apparatus and methods for removing excess fluid, and specifically gas, from a flexible container and sealing the container are provided. The apparatus comprises a device for receiving a flexible container including a product and having a first open end and a second sealed end located at an opposite end of the container from the first open end. The device includes an interior designed to receive at least a portion of the flexible container. The interior is defined, at least in part, by a compressible member that is so constructed and arranged so as to progressively squeeze excess gas located in the interior of the flexible container from the second sealed end out the first open end of the flexible container. The device also includes an integral sealing member that seals the first open end of the flexible container after the compressible member squeezes fluid from the interior of the flexible container.