Abstract: The present invention provides a method of modifying a target substance by contacting the target substance with a catalyst that catalyzes the modification of the target substance. In a preferred embodiment, the method comprises labeling a target substance by contacting the target substance with a label and a catalyst that catalyzes the attachment of the label to the target substance. Preferably, the catalyst catalyzes selectively the reaction between a specific target molecule and a specific label. The attachment of labels may be used to inactivate a biologically active target substance or otherwise modulate its activity. Alternatively, the method may be used to label the target molecule with a detectable label suitable for the sensitive detection of the target substance.

Abstract: A carrier includes supports that attach to opposite sides of the axle of a steerable wheel. Extending generally vertically from the supports are cylindrical tubes that accommodate long and narrow cargo such as baseball and softball bats. The tubes are held near the top by a first bracket extending between them. A second bracket is attached to the first through an elongated slot, and secures the first bracket to the vehicle, for example, at the steering column. The carriers extend vertically beyond the first bracket and so provide support for baseball and softball gloves and mitts. A ball container is suspended from the first bracket between the tubes. When the steering column and steerable wheel are rotated, the carrier rotates also, thereby preventing interference between the carrier and the transportation device. While the invention has application with other transportation devices, particular synergy is found when the inventive carrier is used in combination with a bicycle.