Abstract: The invention relates to methods of (i) treating a subject for a disease, (ii) amelioration of decline of forced vital capacity in a subject in need thereof, (iii) modulating ?V?6 integrin, ?V?1 integrin, or both ?V?6 integrin and ?V?1 integrin in a subject in need thereof, (iv) increasing the expression of one or more genes in a subject in need thereof, (v) decreasing the expression of one or more genes in a subject in need thereof, and (vi) modulating the activity of at least one gene affecting fibrotic activity in a subject in need thereof, comprising administration of compounds of Formula (A), Formula (I), Formula (II), or (S)-4-((2-methoxyethyl)(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl)amino)-2-(quinazolin-4-ylamino)butanoic acid, or a pharmaceutically acceptable salt thereof as described herein; and administering to the subject at least a second drug selected from pirfenidone and nintedanib, or a salt thereof.

Abstract: A method for automatically replacing a first type of content associated with a real-time broadcast with a second type of content is provided. The method may include automatically parsing media content associated with the real-time broadcast and assigning timecode to the parsed media content. The method may further include determining whether the parsed media content includes the first type of content. The method may further include, in response to determining the parsed media content includes the first type of content, automatically determining a context associated with the first type of content. The method may further include automatically identifying the second type of content that matches the determined context. The method may also include, automatically replacing the first type of content in the parsed media content with the second type of content. The method may further include automatically presenting the real-time broadcast with the second type of content.

Abstract: The invention relates to the diagnosis of a condition characterised by TDP-43 proteinopathy by mass spectrometry using one or more signature peptides of TDP-43 species.

Abstract: A method for automatically replacing a first type of content associated with a real-time broadcast with a second type of content is provided. The method may include automatically parsing media content associated with the real-time broadcast and assigning timecode to the parsed media content. The method may further include determining whether the parsed media content includes the first type of content. The method may further include, in response to determining the parsed media content includes the first type of content, automatically determining a context associated with the first type of content. The method may further include automatically identifying the second type of content that matches the determined context. The method may also include, automatically replacing the first type of content in the parsed media content with the second type of content. The method may further include automatically presenting the real-time broadcast with the second type of content.

Abstract: The invention relates to methods for determining whether a subject is afflicted with a motor neuron disease, the method comprising conducting an analysis of cerebrospinal fluid and/or plasma, measuring the level of one or more sterol/oxysterol analytes, and comparing these to reference values. Further, the invention relates to methods of identifying agents suitable for the treatment of MND, and monitoring the progress of the disease.

Abstract: Displaying weather-based information for a flight path is disclosed. A data processing system receives a flight path and retrieves weather-related raster-based forecast data along the flight path. The data processing system then generates a vertical profile for the flight path for all altitudes along the flight path and all flight times along the flight path. The weather-related raster-based forecast data is then converted by the system into polygonal bands that are superimposed by the data processing system onto the vertical profile, resulting in a modified vertical profile. The modified vertical profile is then displayed by the data processing system with a selector in a graphical user interface (GUI) for selecting a flight time of the flight times along the flight path.

Abstract: Displaying weather-based information for a flight path is disclosed. A data processing system receives a flight path and retrieves weather-related raster-based forecast data along the flight path. The data processing system then generates a vertical profile for the flight path for all altitudes along the flight path and all flight times along the flight path. The weather-related raster-based forecast data is then converted by the system into polygonal bands that are superimposed by the data processing system onto the vertical profile, resulting in a modified vertical profile. The modified vertical profile is then displayed by the data processing system with a selector in a graphical user interface (GUI) for selecting a flight time of the flight times along the flight path.

Abstract: The invention relates to methods for determining whether a subject is afflicted with a motor neuron disease, the method comprising conducting an analysis of cerebrospinal fluid and/or plasma, measuring the level of one or more sterol/oxysterol analytes, and comparing these to reference values. Further, the invention relates to methods of identifying agents suitable for the treatment of MND, and monitoring the progress of the disease.

Abstract: The present invention provides novel methods of enhancing CD8+ T cell mediated immunity (also referred to as “CD8+ T cell immunity”) in a patient having a diseased state. In particular, the present invention provides for the enhanced expression of miR-155 in a population of patient specific T cells through the introduction of a nucleic acid molecule encoding a miR-155 transcript or a nucleic acid molecule encoding a chimeric antigen receptor and a miR-155 transcript into those cells, followed by the reintroduction of the T cells into the patient. The present invention also provides methods of enhancing the expansion of these T cells relative to control cells. Increased expansion of CD8+ T cells following enhanced miR-155 expression is directly related to enhanced CD8+ T cell immunity. The present invention further provides methods of enhancing anti-cancer immunity in a patient through the increased expression of miR-155 in patient specific T cells.

Abstract: The invention includes compositions and methods for regulating PI3K p110 delta as an anti-retroviral therapy. The invention includes a method of inhibiting p110 delta, a component of PI3K p110 delta signaling pathway, or any combination thereof in a cell as an anti-retroviral therapeutic approach for treating a retroviral infection, for example HTV. The invention includes a method of modulating PI3K p110 delta in a cell infected with a retrovirus by contacting the cell with an effective amount of a composition comprising an inhibitor of PI3K P110 delta.

Abstract: The invention includes compositions and methods for regulating PI3K p110 delta as an anti-retroviral therapy. The invention includes inhibiting p110 delta, a component of PI3K p110 delta signaling pathway, or any combination thereof in a cell as an anti-retroviral therapeutic approach for treating a retroviral infection, for example HIV. The invention includes a method of modulating PI3K p110 delta in a cell infected with a retrovirus by contacting the cell with an effective amount of a composition comprising an inhibitor of PI3K p110 delta.

Abstract: The invention includes compositions and methods for regulating p110 delta as an anti-influenza virus therapy. The invention includes inhibiting p110 delta, a component of p110 delta signaling pathway, or any combination thereof in a cell as an anti-influenza viral therapeutic approach for treating influenza virus infection. The invention includes a method of modulating p110 delta in a cell by contacting the cell with an effective amount of a composition comprising an inhibitor of p110 delta.

Abstract: The invention includes compositions and methods for regulating PI3K p110 delta as an anti-retroviral therapy. The invention includes inhibiting p110 delta, a component of PI3K p110 delta signaling pathway, or any combination thereof in a cell as an anti-retroviral therapeutic approach for treating a retroviral infection, for example HIV. The invention includes a method of modulating PI3K p110 delta in a cell infected with a retrovirus by contacting the cell with an effective amount of a composition comprising an inhibitor of PI3K p110 delta.