Abstract: The present invention concerns antigen binding proteins specifically binding melanoma associated antigen A (MAGE-A) protein-derived antigens. The invention in particular provides antigen binding proteins which specifically bind to the MAGE-A antigenic peptide comprising or consisting of SEQ ID NO: 1 in a complex with a major histocombatibility (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said MAGE-A peptide/MHC complex. The antigen binding proteins of the invention are of use for the diagnosis, treatment and prevention of MAGE-A expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: A system for producing plastic containers with a heating device for heating plastic preforms, wherein the heating device has a transport device for transporting plastic preforms along a predetermined first transport path, and a plurality of holding devices for holding the plastic preforms and at least one heating device which heats the plastic preforms during the transport thereof and comprising a forming device for forming the plastic preforms to form plastic containers. The forming device is configured for expanding the plastic preforms heated by the heating device by applying a flowable medium, and includes a plurality of forming stations which form the plastic preforms to form the plastic containers. Both the heating device and the forming device have changeable elements, wherein the system has a changing device configured for changing both changeable elements of the heating device and changeable elements of the forming device.

Abstract: The present invention concerns antigen binding proteins directed against PRAME protein-derived antigens. The invention in particular provides antigen binding proteins which are specific for the tumor expressed antigen PRAME, wherein the tumor antigen comprises or consists of SEQ ID NO: 50 and is in a complex with a major histocompatibility complex (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said PRAME peptide. The antigen binding proteins of the invention are for use in the diagnosis, treatment and prevention of PRAME expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising said nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: The present invention pertains to antigen recognizing constructs against COL6A3 antigens. The invention in particular provides novel engineered T cell receptor (TCR) based molecules which are selective and specific for the tumor expressing antigen COL6A3. The TCR of the invention, and COL6A3 antigen binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of COL6A3 expressing cancerous diseases. Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention.

Abstract: In order to simplify the starting-up of a transport device in the form of a long-stator linear motor, a thermal design and/or an electrical design and/or a mechanical design of the transport device is checked using a time course of the electrical control variable of the drive coils for producing a product flow, and, before starting-up, a transport device configuration having a thermal and/or electrical and/or mechanical configuration is changed if the product flow cannot be implemented due to the thermal design and/or electrical design and/or mechanical design.

Abstract: The invention relates to a medical instrument having an elongated shaft, a movable tool at a distal end of the shaft, a handle with a movable grip part at a proximal end of the shaft, and a force transmission element which can be moved in the longitudinal direction of the instrument and is operatively connected to the movable grip part and to the tool such that an actuation of the movable grip part is converted into a movement of the tool. The instrument has a spring assembly that is arranged on the handle and has at least one leg spring, which has at least one winding and two legs, and a pin, wherein the at least one winding extends about the pin. When the movable grip part is actuated, a force is applied to at least one of the legs of the leg spring, said force reducing the friction between the winding and the pin such that the leg spring can be rotated about the pin and the force transmission element and the tool can be moved.

Abstract: An aircraft propulsion unit includes an electric motor, at least one accessory unit used for operating the electric motor, an inverter module, the inverter module including a plurality of inverters for powering the electric motor and the at least one accessory unit, and a cooling system coupled to the electric motor and the inverter module, the cooling system comprising a coolant path for circulating a coolant through or adjacent to the electric motor and the at least one accessory unit.

Abstract: Disclosed is a Transport apparatus (1) for supply rolls (8) with packaging material wound thereon. The transport apparatus (1) comprises at least one driverless transport vehicle (2) and at least one adapter (3). The adapter (3) is preferably connectable to the driverless transport vehicle (2), as well as being separable from the driverless transport vehicle (2). The adapter (3) is moreover designed to hold at least one supply roll (8).

Abstract: A dielectric wave guide cable (1) includes a tubular core (2) made from a low loss material having a certain permittivity. The tubular core (2) is encompassed by a cladding (3) having, compared to the tubular core (2), a lower permittivity. The tubular core (2) may be coated on the inside by a coating (3) having a higher permittivity. The cladding (3) may be encompassed by a jacket (4).

Abstract: A system and method are provided for creating an image including quantified flow within vessels of a subject. The method includes providing a single-sweep, three-dimensional (3D) image volume acquired from a subject during a single pass of a computed tomography (CT) imaging system as the subject receives a dose of a contrast agent and determining a phase shift corresponding to pulsatile contrast in vessels within the single-sweep, 3D image volume. The method further includes quantifying a flow through the vessels within the single-sweep, 3D image volume using the phase shift and generating a report including indicating flow through the vessels within the 3D image volume.

Abstract: A board to board connector assembly (1) includes a first connector (2) suitable to be arranged on a first printed circuit board (3) and a second connector (4) suitable to be arranged on a second printed circuit board (5). An adapter (6) is arranged in a mounted position between and interconnected to the first and the second connector (2, 4). The adapter (6) includes an adapter inner conductor (7) and an adapter outer conductor (8). The adapter outer conductor (8) is arranged separate from the adapter inner conductor (7) and comprises a bore (18) in which the adapter inner conductor (7) is arranged.

Abstract: A drive device for moving a leaf, in particular a door leaf or a window leaf, with an electric machine including an, in particular single, stator and an, in particular single, rotor, which can be rotated about a machine axis, and with a gear coupled to the electric machine. The gear has a first gear element, which can be rotated coaxially with the machine axis, with the first gear element being connected to the rotor in a rotationally-fixed manner.

Abstract: A drive device for moving a leaf, in particular a door leaf or window leaf, includes an electric machine. The electric machine is an axial flux machine having a stator, in particular a single stator, and a rotor, in particular a single rotor, which is rotatable relative to the stator about a machine axis.

Abstract: An apparatus comprising a first and second terminal configured to couple the apparatus to a first and second bus wire of a communication bus; a transceiver arrangement for communicating with one or more network nodes via the communication bus, the transceiver arrangement configured to provide and receive differential signalling according to a communication scheme to/from the communication bus, wherein the communication scheme defines at least a voltage to be used to provide said differential signalling; the apparatus configured to: based on a fault detection signal indicative of the occurrence of a fault in at least the communication bus, transmit a reconfiguration signal for the network nodes and wherein at least part of the reconfiguration signal has a high-voltage-level comprising a voltage higher than that defined in the communication scheme for said differential signalling; and wherein said reconfiguration signal is configured to cause the network nodes to switch single-ended signalling.

Abstract: A coaxial connecting member (1) for transmitting radio-frequency signals between a first and a second circuit board (2, 3) includes an inner conductor (4), an outer conductor (5) and an insulating member (6) arranged between the inner conductor (4) and the outer conductor (5). The inner conductor (4) and/or the outer conductor (5) comprise a first and a second end section (7, 8) to interconnect the inner conductor (4) to the first and the second circuit board (2, 3). The first and the second end section (7, 8) are interconnected to each other by at least one elastically deformable transversal section (9) to compensate axial and/or lateral misalignment of the first and the second circuit board (2, 3) with respect to each other.

Abstract: A method represents an environment via a display unit arranged on a person and visible for the person as a display image within the scope of a simulation. The simulation is carried out in an interaction environment, wherein a number of actuatable interaction elements are arranged in the interaction environment. An interaction environment image capture, depicting the interaction environment, is created by use of a first image capturing unit arranged on the person or relative to the person. A position of the person is determined in the interaction environment and based on the position of the person an environment image is provided. An image mask is provided which depicts the individual interaction elements contained in the interaction environment image capture and is represented in the display image. The interaction environment image capture and the environment image are superimposed using the image mask and then displayed on the display unit.

Abstract: A system and method are provided for creating an image including quantified flow within vessels of a subject. The method includes providing a single-sweep, three-dimensional (3D) image volume acquired from a subject during a single pass of a computed tomography (CT) imaging system as the subject receives a dose of a contrast agent and determining a phase shift corresponding to pulsatile contrast in vessels within the single-sweep, 3D image volume. The method further includes quantifying a flow through the vessels within the single-sweep, 3D image volume using the phase shift and generating a report including indicating flow through the vessels within the 3D image volume.

Abstract: A door drive for arrangement on or in connection with a door system, whereby at least one leaf element of the door system is movable. The door drive includes a motor unit with a housing, in which a stator is stationarily received, and wherein a rotor is arranged so as to be rotationally-movable in the housing and includes an output shaft, wherein the output shaft can be brought into operative connection in a driving manner with the leaf element. The rotor includes a support body, on which receiving fields are formed, on which permanent magnets are adhered.

Abstract: A torsional probe for a metrology instrument includes a cantilever coupled to a support structure via a torsion bar. The cantilever, support structure, and arms of torsion bar have substantially the same thickness. A method of manufacture of the torsion probe, as well as a method of using the torsion probe to measure photothermal induced surface displacement of a sample are also described.