Patents by Inventor Martina Beishuizen
Martina Beishuizen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10100344Abstract: The present invention relates to a mutant microbial host cell which is deficient in the production of the AgsE protein or in the production of an homologous thereof if compared with a parent microbial host cell which has not been modified and measured under the same conditions. It has been surprisingly found that when the mutant microbial host cell according to the invention is used in a method to produce a compound of interest, for example an enzyme, an improved yield of said compound is obtained if compared to a method in which a parent host cell which has not been modified is used when measured under the same conditions.Type: GrantFiled: January 27, 2017Date of Patent: October 16, 2018Assignee: DSM IP ASSETS B.V.Inventors: Noël Nicolaas Maria Elisabeth Van Peij, Martina Beishuizen, Peter Jozef Ida Van De Vondervoort
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Patent number: 10035986Abstract: The present invention relates to a mutant microbial host cell which is deficient in the production of the AgsE protein or in the production of an homologous thereof if compared with a parent microbial host cell which has not been modified and measured under the same conditions. It has been surprisingly found that when the mutant microbial host cell according to the invention is used in a method to produce a compound of interest, for example an enzyme, an improved yield of said compound is obtained if compared to a method in which a parent host cell which has not been modified is used when measured under the same conditions.Type: GrantFiled: July 19, 2013Date of Patent: July 31, 2018Assignee: DSM IP ASSETS B.V.Inventors: Noël Nicolaas Maria Elisabeth Van Peij, Martina Beishuizen, Peter Jozef Ida Van De Vondervoort
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Patent number: 9745563Abstract: The present invention relates to a mutant microbial host cell which has been modified, preferably in its genome, to result in a deficiency in the production of a polypeptide having ?-amylase activity AmyC or an homologous thereof. It has been surprisingly found that when the mutant microbial host cell according to the invention is used in a method to produce a compound of interest, for example an enzyme, an improved purity of the product is obtained.Type: GrantFiled: July 19, 2013Date of Patent: August 29, 2017Assignee: DSM IP ASSETS B.V.Inventors: Noel Nicolaas Maria Elisabeth Van Peij, Martina Beishuizen, Peter Jozef Ida Van De Vondervoort
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Publication number: 20170175158Abstract: The present invention relates to a mutant microbial host cell which is deficient in the production of the AgsE protein or in the production of an homologous thereof if compared with a parent microbial host cell which has not been modified and measured under the same conditions. It has been surprisingly found that when the mutant microbial host cell according to the invention is used in a method to produce a compound of interest, for example an enzyme, an improved yield of said compound is obtained if compared to a method in which a parent host cell which has not been modified is used when measured under the same conditions.Type: ApplicationFiled: January 27, 2017Publication date: June 22, 2017Inventors: Noël Nicolaas Maria Elisabeth VAN PEIJ, Martina BEISHUIZEN, Peter Jozef Ida VAN DE VONDERVOORT
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Patent number: 9657309Abstract: The present invention relates to a method for carrying out recombination at a target locus.Type: GrantFiled: March 12, 2013Date of Patent: May 23, 2017Assignee: DSM IP ASSETS B.V.Inventors: Noel Nicolaas Maria Elisabeth Van Peij, Martina Beishuizen, Yvonne Johannes Odilia Arendsen
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Publication number: 20150191705Abstract: The present invention relates to a mutant microbial host cell which is deficient in the production of the AgsE protein or in the production of an homologous thereof if compared with a parent microbial host cell which has not been modified and measured under the same conditions. It has been surprisingly found that when the mutant microbial host cell according to the invention is used in a method to produce a compound of interest, for example an enzyme, an improved yield of said compound is obtained if compared to a method in which a parent host cell which has not been modified is used when measured under the same conditions.Type: ApplicationFiled: July 19, 2013Publication date: July 9, 2015Inventors: Noël Nicolaas Maria Elisabeth Van Peij, Martina Beishuizen, Peter Jozef Ida Van De Vondervoort
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Publication number: 20150166970Abstract: The present invention relates to a mutant microbial host cell which has been modified, preferably in its genome, to result in a deficiency in the production of a polypeptide having ?-amylase activity AmyC or an homologous thereof. It has been surprisingly found that when the mutant microbial host cell according to the invention is used in a method to produce a compound of interest, for example an enzyme, an improved purity of the product is obtained.Type: ApplicationFiled: July 19, 2013Publication date: June 18, 2015Inventors: Noel Nicolaas Maria Elisabeth Van Peij, Martina Beishuizen, Peter Jozef Ida Van De Vondervoort
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Publication number: 20150050739Abstract: The present invention relates to a method for carrying out recombination at a target locus.Type: ApplicationFiled: March 12, 2013Publication date: February 19, 2015Inventors: Noel Nicolaas Maria Elisabeth Van Peij, Martina Beishuizen, Yvonne Johannes Odilia Arendsen
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Patent number: 8945898Abstract: The present invention relates to a method for the production of a compound of interest by microbial fermentation, wherein the microbial host cell used has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The present invention further relates to a microbial host cell that has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The invention further relates to a compound of interest.Type: GrantFiled: July 1, 2011Date of Patent: February 3, 2015Assignee: DSM IP Assets B.V.Inventors: Noel Nicolaas Maria Elisabeth Van Peij, Marcus Hans, Martina Beishuizen, Dick Schipper, Robertus Antonius Mijndert Van Der Hoeven, Olaf Leonardus Schouten
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Publication number: 20130144034Abstract: The present invention relates to a method for the production of a compound of interest by microbial fermentation, wherein the microbial host cell used has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The present invention further relates to a microbial host cell that has been modified in its genome such that it results in a deficiency in the production of at least one non-ribosomal peptide synthase. The invention further relates to a compound of interest.Type: ApplicationFiled: July 1, 2011Publication date: June 6, 2013Applicant: DSM IP ASSETS B.V.Inventors: Noel Nicolaas Maria Elisabeth Van Peij, Marcus Hans, Martina Beishuizen, Dick Schipper, Robertus Antonius Mijndert Van Der Hoeven, Olaf Leonardus Schouten
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Patent number: 7968312Abstract: The present invention relates to polypeptides that have an activity corresponding to at least one activity of the SEC61 polypeptide, polynucleotides encoding these polypeptides and the use thereof in the preparation of host cells suitable for production of a polypeptide of interest. Such host cells may have an increased capacity to secrete a polypeptide of interest.Type: GrantFiled: June 16, 2005Date of Patent: June 28, 2011Assignee: DSM IP Assets B.V.Inventors: Cornelis Maria Jacobus Sagt, Nöel Nicolaas Maria Elisabeth Van Peij, Linda De Lange, Martina Beishuizen, Serge Petrus Donkers
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Publication number: 20090004693Abstract: The present invention relates to polypeptides that have an activity corresponding to at least one activity of the SEC61 polypeptide, polynucleotides encoding these polypeptides and the use thereof in the preparation of host cells suitable for production of a polypeptide of interest. Such host cells may have an increased capacity to secrete a polypeptide of interest.Type: ApplicationFiled: June 16, 2005Publication date: January 1, 2009Inventors: Cornelis Maria Sagt, Noel Nicolaas Maria Elisabeth Peij, Linda De Lange, Martina Beishuizen, Serge Petrus Donkers