Patents by Inventor Martina Hasova

Martina Hasova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hyaluronic acid derivative, method of preparation thereof, method of modification thereof and use thereof
    Patent number: 9522966
    Abstract: The invention relates to the preparation and use of ?,?-unsaturated aldehyde of hyaluronan having a double bond in the positions 4 and 5 and an aldehydic group in the position 6 of the glucosamine part of the polysaccharide. The method of preparation is based on dehydration of hyaluronan having an aldehydic group in the position 6 of the glucosamine part of the polysaccharide. Two methods have been described, which are dehydration in a solution or heating in solid state in absence of solvents, bases or other additives. This derivative allows stabilization of conjugates of hyaluronan with amino compounds by means of a multiple bond from the aldehyde side, and therefore, it is possible to effectively immobilize practically any compound containing an amino group to such modified hyaluronan in physiological conditions. In case of using a diamine or compounds or polymers containing three or more amino groups, it is possible to prepare crosslinked hyaluronan derivatives.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: December 20, 2016
    Assignee: Contipro Biotech s.r.o.
    Inventors: Radovan Buffa, Petra Sedova, Vladimir Velebny, Lucie Wolfova, Ivana Basarabova, Robert Pospisil, Martina Hasova, Kristina Nesporova
  • Hyaluronic Acid Derivative, Method of Preparation Thereof, Method of Modification Thereof and Use Thereof
    Publication number: 20150175717
    Abstract: The invention relates to the preparation and use of ?,?-unsaturated aldehyde of hyaluronan having a double bond in the positions 4 and 5 and an aldehydic group in the position 6 of the glucosamine part of the polysaccharide. The method of preparation is based on dehydration of hyaluronan having an aldehydic group in the position 6 of the glucosamine part of the polysaccharide. Two methods have been described, which are dehydration in a solution or heating in solid state in absence of solvents, bases or other additives. This derivative allows stabilization of conjugates of hyaluronan with amino compounds by means of a multiple bond from the aldehyde side, and therefore, it is possible to effectively immobilize practically any compound containing an amino group to such modified hyaluronan in physiological conditions. In case of using a diamine or compounds or polymers containing three or more amino groups, it is possible to prepare crosslinked hyaluronan derivatives.
    Type: Application
    Filed: August 8, 2013
    Publication date: June 25, 2015
    Applicant: CONTIPRO BIOTECH S.R.O.
    Inventors: Radovan Buffa, Petra Sedova, Vladimir Velebny, Lucie Wolfova, Ivana Basarabova, Robert Pospisil, Martina Hasova, Kristina Nesporova