Patents by Inventor Marvin M. Goldenberg

Marvin M. Goldenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-alkenyl-3-hydroxybenzo[b]thiophene-2-carboxamide derivatives as dual cyclooxygenase and lipoxygenase inhibitors
    Patent number: 5068248
    Abstract: Method for increasing resistance to gastro-intestinal irritation, and for the treatment of pain, fever, inflammation, arthritic conditions, asthma, allergic disorders, skin diseases, cardiovascular disorders, psoriasis, inflammatory bowel disease, glaucoma or other prostaglandin and/or leukotriene mediated diseases comprising the administration to a subject in need of such treatment, a non-toxic therapeutically effective amount of compound of formula I: ##STR1##
    Type: Grant
    Filed: June 22, 1989
    Date of Patent: November 26, 1991
    Assignee: Merck & Co., Inc.
    Inventors: Allan N. Tischler, Philippe L. Durette, Bruce E. Witzel, Kathleen M. Rupprecht, Timothy F. Gallagher, Marvin M. Goldenberg, Debra L. Allison
  • N-alkenyl-3-hydroxybenzo[b]thiophene-2-carboxamide derivatives as dual cyclooxygenase and lipoxygenase inhibitors
    Patent number: 4760086
    Abstract: N-Alkenyl-3-hydroxybenzo[b]thiophene-2-carboxamide derivatives have been prepared by:(1) treating a substituted 2-halobenzoate with thioacetamide followed by N-alkenylation with appropriate agents, such as aldehydes, ketones, enol ethers, epoxides, acetals or ketals;(2) treating a substituted thiosalicylate with an appropriately substituted haloacetamide, followed by dehydration; and(3) further synthetic modification of compounds prepared above.These compounds have been found to be effective inhibitors of both cyclooxygenase and lipoxygenase and thereby useful in the treatment of pain, fever, inflammation, arthritic conditions, asthma, allergic disorders, skin diseases, cardiovascular disorders, psoriasis, inflammatory bowel disease, glaucoma or other prostaglandins and/or leukotriene mediated diseases.
    Type: Grant
    Filed: February 27, 1985
    Date of Patent: July 26, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Allan N. Tischler, Bruce E. Witzel, Philippe L. Durette, Kathleen M. Rupprecht, Timothy F. Gallagher, Debra L. Allison, Marvin M. Goldenberg
  • Anti-inflammatory/analgesic combination of cyclo-(N-methyl-Ala-Tyr-D-Trp-Lys-Val-Phe) and a selected non-steroidal anti-inflammatory drug (NSAID)
    Patent number: 4474766
    Abstract: Combinations of cyclo-(N-methyl-Ala-Tyr-D-Trp-Lys-Val-Phe) and a NSAID have been found to exhibit much lower gastric lesions or ulcers than normally associated with NSAIDs and are thereby clinically useful in long-term therapy for patients suffering from chronic rheumatoid arthritis or osteoarthritis.
    Type: Grant
    Filed: June 27, 1983
    Date of Patent: October 2, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Marvin M. Goldenberg, Doris L. Keller
  • Gastric cytoprotection with L-363,586
    Patent number: 4470974
    Abstract: The somatostatin analog L-363,586 is a cyclic hexapeptide having the structure; cyclo-(N-methyl-Ala-Tyr-d-Trp-Lys-Val-Phe). L-363,586 has been found to be useful for inducing gastric cytoprotection via a mechanism not involving the inhibition of gastric acid secretions. Specific therapeutic utilities include, erosive gastritis, erosive esophagitis, inflammatory bowel disease and ethanol induced hemorrhagic gastric erosions.
    Type: Grant
    Filed: June 27, 1983
    Date of Patent: September 11, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Marvin M. Goldenberg, Doris L. Keller
  • Anti-inflammatory/analgesic combination of .alpha.-fluoromethylhistidine and a selected non-steroidal anti-inflammatory drug (NSAID)
    Patent number: 4447443
    Abstract: Combinations of .alpha.-fluoromethylhistidine and a NSAID have been found to exhibit higher efficacy and shorter onset of action in the treatment of pain and inflammation.
    Type: Grant
    Filed: November 15, 1982
    Date of Patent: May 8, 1984
    Assignee: Merck & Co., Inc.
    Inventor: Marvin M. Goldenberg
  • 2,3-Dihydro-4H-1-benzopyran-4-one O-carbamoyl oximes
    Patent number: 4169097
    Abstract: A series of 2,3-dihydro-4H-1-benzopyran-4-one O-carbamoyl-oximes are useful as gastric antisecretory agents.
    Type: Grant
    Filed: April 3, 1978
    Date of Patent: September 25, 1979
    Assignee: Morton-Norwich Products, Inc.
    Inventors: George C. Wright, Thomas J. Schwan, Marvin M. Goldenberg
  • 4-Acetoxy-1,2,3,4-tetrahydro-2,2-dimethyl-6,7-methylenedioxyisoq uinolinium iodide
    Patent number: 4125529
    Abstract: 4-Acetoxy-1,2,3,4-tetrahydro-2,2-dimethyl-6,7-methylenedioxyisoquinolinium iodide is useful as a gastric acid antisecretory agent.
    Type: Grant
    Filed: August 19, 1977
    Date of Patent: November 14, 1978
    Assignee: Morton-Norwich Products, Inc.
    Inventors: Thomas J. Schwan, Marvin M. Goldenberg
  • 6-Nitro-or amino-4-chromanone oxime
    Patent number: 4115405
    Abstract: The compounds 6-nitro- or amino-4-chromanone oxime are useful as anti-inflammatory agents.
    Type: Grant
    Filed: July 1, 1977
    Date of Patent: September 19, 1978
    Assignee: Morton-Norwich Products, Inc.
    Inventors: George C. Wright, Marvin M. Goldenberg
  • N-Benzyl-4-chromanamines
    Patent number: 4115407
    Abstract: Certain N-benzyl-4-chromanamines are useful as anti-inflammatory agents.
    Type: Grant
    Filed: July 1, 1977
    Date of Patent: September 19, 1978
    Assignee: Morton-Norwich Products, Inc.
    Inventors: George C. Wright, Marvin M. Goldenberg
  • 3-(4-Chromanylamino)-2-oxazolidinones
    Patent number: 4108862
    Abstract: Certain 3-(4-chromanylamino)-2-oxazolidinones are useful as gastric antisecretory agents.
    Type: Grant
    Filed: July 1, 1977
    Date of Patent: August 22, 1978
    Assignee: Morton-Norwich Products, Inc.
    Inventors: George C. Wright, Marvin M. Goldenberg
  • 7-Dimethylamino-4-chromanone
    Patent number: 4108872
    Abstract: The compound 7-dimethylamino-4-chromanone is useful as an anti-inflammatory agent.
    Type: Grant
    Filed: July 1, 1977
    Date of Patent: August 22, 1978
    Assignee: Morton-Norwich Products, Inc.
    Inventors: George C. Wright, Marvin M. Goldenberg
  • O-(carboxymethyl)-4-chromanone oxime
    Patent number: 4108873
    Abstract: The compound O-(carboxymethyl)-4-chromanone oxime is useful as a gastric antisecretory agent.
    Type: Grant
    Filed: July 1, 1977
    Date of Patent: August 22, 1978
    Assignee: Morton-Norwich Products, Inc.
    Inventors: George C. Wright, Marvin M. Goldenberg
  • 6-Methoxy-N-vanillylidene-4-chromanamine
    Patent number: 4095023
    Abstract: The compound 6-methoxy-N-vanillylidene-4-chromanamine is useful as an anti-inflammatory.
    Type: Grant
    Filed: July 1, 1977
    Date of Patent: June 13, 1978
    Assignee: Morton-Norwich Products, Inc.
    Inventors: George C. Wright, Marvin M. Goldenberg
  • N-arylidene-4-chromanamines
    Patent number: 4093799
    Abstract: Certain N-arylidene-4-chromanamines are useful as gastric antisecretory agents.
    Type: Grant
    Filed: July 1, 1977
    Date of Patent: June 6, 1978
    Assignee: Morton-Norwich Products, Inc.
    Inventors: George C. Wright, Marvin M. Goldenberg
  • 3-[(4-Chromanylidene)amino]-2-oxazolidinones
    Patent number: 4093627
    Abstract: A series of 3-[(4-chromanylidene)amino]-2-oxazolidinones are useful as gastric antisecretory agents.
    Type: Grant
    Filed: July 1, 1977
    Date of Patent: June 6, 1978
    Assignee: Morton-Norwich Products, Inc.
    Inventors: George C. Wright, Marvin M. Goldenberg
  • Method for treating inflammation
    Patent number: 4036981
    Abstract: The use of trans-5-(4-chlorophenyl)-2-furanacrylic acid as an anti-inflammatory agent is described.
    Type: Grant
    Filed: July 12, 1976
    Date of Patent: July 19, 1977
    Assignee: Morton-Norwich Products, Inc.
    Inventor: Marvin M. Goldenberg
  • 5-Phenyl-2-furanyl-oxo or-hydroxy alkanoic acids and ethyl esters as gastric acid antisecretory agents
    Patent number: 4035394
    Abstract: Certain 5-phenyl-2-furanyl-oxo or-hydroxy alkanoic acids and ethyl esters are useful as gastric acid antisecretory agents.
    Type: Grant
    Filed: February 24, 1976
    Date of Patent: July 12, 1977
    Assignee: Morton-Norwich Products, Inc.
    Inventors: Stanford S. Pelosi, Jr., Marvin M. Goldenberg
  • 2-Bromo-1-hydroxyquinolizinium bromide substituted anilinium salts
    Patent number: 4020075
    Abstract: 2-Bromo-1-hydroxyquinolizinium bromide substituted anilinium salts are useful as antiinflammatory agents.
    Type: Grant
    Filed: May 13, 1974
    Date of Patent: April 26, 1977
    Assignee: Morton-Norwich Products, Inc.
    Inventors: Robert J. Alaimo, Marvin M. Goldenberg
  • Method of combatting gastric ulceration
    Patent number: 4016268
    Abstract: Bismuth subsalicylate co-administered with anti-inflammatory drugs combats gastric ulceration associated with such drugs.
    Type: Grant
    Filed: October 6, 1975
    Date of Patent: April 5, 1977
    Assignee: Morton-Norwich Products, Inc.
    Inventors: Marvin M. Goldenberg, Leroy J. Honkomp