Patents by Inventor Marvin Siegel
Marvin Siegel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9302531Abstract: A canvas stretcher frame and method for fabricating same is provided comprised of four perimeter members and four corner members. Each of the perimeter members demonstrates continuous and uniform corner tine receiving channels, mounting material receiving channels and a cross bar mounting channel running the entire length of the perimeter member. The corner members are formed of two corner sections and can be opened, via a key to increase frame perimeter. Due to the continuous and uniform shape and configuration of the perimeter members and the affixation means formed therein, the perimeter members may be cut to form a frame of any desired perimeter dimension without need for further mortizing or machining of the cut member prior to assembly.Type: GrantFiled: July 22, 2014Date of Patent: April 5, 2016Inventor: Marvin Siegel
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Publication number: 20160023506Abstract: A canvas stretcher frame and method for fabricating same is provided comprised of four perimeter members and four corner members. Each of the perimeter members demonstrates continuous and uniform corner tine receiving channels, mounting material receiving channels and a cross bar mounting channel running the entire length of the perimeter member. The corner members are formed of two corner sections and can be opened, via a key to increase frame perimeter. Due to the continuous and uniform shape and configuration of the perimeter members and the affixation means formed therein, the perimeter members may be cut to form a frame of any desired perimeter dimension without need for further mortising or machining of the cut member prior to assembly.Type: ApplicationFiled: July 22, 2014Publication date: January 28, 2016Inventor: Marvin Siegel
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Publication number: 20110142873Abstract: A method of treating or preventing a condition related to an HPV infection is provided. The method comprises administering to a subject a composition comprising a purified Hsp65-E7 fusion protein (HspE7) admixed with an immune stimulant selected from the group consisting of CpG, a TLR3 agonist such as PolyI:C, PolyICLC, mono-phosphoryl-lipid A (MPL), MPL-trehalose 6,6?-dimycolate (MPL-TDM), and anti-CD40. A composition comprising HspE7 and one or more than one of CpG, a TLR3 agonist such as PolyI:C, PolyICLC, MPL, MPL-TDM, and anti-CD40, and method of reducing a tumor or virus development in a mammal or subject in need thereof by using the composition are also provided.Type: ApplicationFiled: May 30, 2007Publication date: June 16, 2011Inventors: Gerry Rowse, John Webb, Marvin Siegel, Peter Emtage
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Patent number: 7754449Abstract: Disclosed is a method of treating a wart in a subject by administering to the subject a composition containing (1) a heat shock protein or an immunostimulatory fragment thereof, and (2) a protein of a human papilloma virus or an antigenic fragment thereof. Also disclosed is a method of treating a human papilloma virus infection in a subject infected or suspected of being infected with a human papilloma virus of a first type by administering to the subject a composition containing (1) a heat shock protein or an antigenic fragment thereof, and (2) a protein of a human papilloma virus of a second type or an antigenic fragment thereof, where the first type and second type are different.Type: GrantFiled: April 26, 2007Date of Patent: July 13, 2010Assignee: Nventa Biopharmaceuticals CorporationInventors: John R. Neefe, Stephen E. Goldstone, Mark T. Winnett, Marvin Siegel, Leslie J. Boux
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Publication number: 20080063661Abstract: Disclosed is a method of treating a wart in a subject by administering to the subject a composition containing (1) a heat shock protein or an immunostimulatory fragment thereof, and (2) a protein of a human papilloma virus or an antigenic fragment thereof. Also disclosed is a method of treating a human papilloma virus infection in a subject infected or suspected of being infected with a human papilloma virus of a first type by administering to the subject a composition containing (1) a heat shock protein or an antigenic fragment thereof, and (2) a protein of a human papilloma virus of a second type or an antigenic fragment thereof, where the first type and second type are different.Type: ApplicationFiled: April 26, 2007Publication date: March 13, 2008Inventors: John Neefe, Stephen Goldstone, Mark Winnett, Marvin Siegel, Leslie Boux
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Publication number: 20070160620Abstract: The present invention relates to a vaccine for inducing an immune response to an antigen in a vertebrate (e.g., mammal) comprising an antigen and all or a portion of a stress protein or all or a portion of a protein having an amino acid sequence sufficiently homologous to the amino acid sequence of the stress protein to induce the immune response against the antigen. In a particular embodiment, the present invention relates to vaccines and compositions which induce a CTL response in a mammal comprising an antigen and all or a portion of a stress protein. In another embodiment, the invention relates to vaccines and compositions which induce an immune response to an influenza virus in a mammal comprising an antigen of the influenza virus and all or a portion of one or more stress proteins. The invention also relates to vaccines and compositions for inducing a CTL response to a tumor-associated antigen comprising a tumor-associated antigen and all or a portion of the stress protein.Type: ApplicationFiled: December 7, 2006Publication date: July 12, 2007Inventors: Lee Mizzen, Lawrence Anthony, Huacheng Wu, Marvin Siegel
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Patent number: 7211411Abstract: Disclosed is a method of treating a wart in a subject by administering to the subject a composition containing (1) a heat shock protein or an immunostimulatory fragment thereof, and (2) a protein of a human papilloma virus or an antigenic fragment thereof. Also disclosed is a method of treating a human papilloma virus infection in a subject infected or suspected of being infected with a human papilloma virus of a first type by administering to the subject a composition containing (1) a heat shock protein or an antigenic fragment thereof, and (2) a protein of a human papilloma virus of a second type or an antigenic fragment thereof, where the first type and second type are different.Type: GrantFiled: June 18, 2004Date of Patent: May 1, 2007Assignee: Nventa Biopharmaceuticals CorporationInventors: John R. Neefe, Stephen E. Goldstone, Mark T. Winnett, Marvin Siegel, Leslie J. Boux
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Patent number: 7157089Abstract: The present invention relates to a vaccine for inducing an immune response to an antigen in a vertebrate (e.g., mammal) comprising an antigen and all or a portion of a stress protein or all or a portion of a protein having an amino acid sequence sufficiently homologous to the amino acid sequence of the stress protein to induce the immune response against the antigen. In a particular embodiment, the present invention relates to vaccines and compositions which induce a CTL response in a mammal comprising an antigen and all or a portion of a stress protein. In another embodiment, the invention relates to vaccines and compositions which induce an immune response to an influenza virus in a mammal comprising an antigen of the influenza virus and all or a portion of one or more stress proteins. The invention also relates to vaccines and compositions for inducing a CTL response to a tumor-associated antigen comprising a tumor-associated antigen and all or a portion of the stress protein.Type: GrantFiled: November 25, 1997Date of Patent: January 2, 2007Assignee: Stressgen Biotechnologies CorporationInventors: Lee Mizzen, Lawrence S. D. Anthony, Huacheng Bill Wu, Marvin Siegel
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Publication number: 20050202044Abstract: The present invention relates to a vaccine for inducing an immune response to an antigen in a vertebrate (e.g., mammal) comprising an antigen and all or a portion of a stress protein or all or a portion of a protein having an amino acid sequence sufficiently homologous to the amino acid sequence of the stress protein to induce the immune response against the antigen. In a particular embodiment, the present invention relates to vaccines and compositions which induce a CTL response in a mammal comprising an antigen and all or a portion of a stress protein. In another embodiment, the invention relates to vaccines and compositions which induce an immune response to an influenza virus in a mammal comprising an antigen of the influenza virus and all or a portion of one or more stress proteins. The invention also relates to vaccines and compositions for inducing a CTL response to a tumor-associated antigen comprising a tumor-associated antigen and all or a portion of the stress protein.Type: ApplicationFiled: February 19, 2004Publication date: September 15, 2005Inventors: Lee Mizzen, Lawrence Anthony, Huacheng Wu, Marvin Siegel
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Patent number: 6921534Abstract: The invention relates to HBV antigen-containing compositions that are useful in treating or preventing HBV infection. The content of the compositions can vary, as described herein, but the compositions comprise a stress protein, or a portion (e.g., a fragment) or derivative thereof, and an HBV antigen.Type: GrantFiled: February 5, 2002Date of Patent: July 26, 2005Assignee: Stressgen Biotechnologies CorporationInventors: Lee A. Mizzen, Marvin Siegel, Hongwei Liu
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Publication number: 20050152917Abstract: The invention relates to HBV antigen-containing compositions that are useful in treating or preventing HBV infection. The content of the compositions can vary, as described herein, but the compositions comprise a stress protein, or a portion (e.g., a fragment) or derivative thereof, and an HBV antigen.Type: ApplicationFiled: September 14, 2004Publication date: July 14, 2005Inventors: Lee Mizzen, Marvin Siegel, Hongwei Liu
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Publication number: 20050089841Abstract: The invention provides compositions and methods for stimulating a Th1-like response in vitro. Compositions include fusion proteins and conjugates that contain at least a portion of a heat shock protein. A Th1-like response can be elicited by contacting in vitro a cell sample containing naive lymphocytes with a fusion protein or conjugate of the invention. The Th1-like response can be detected by measuring IFN-gamma produced by the cell sample.Type: ApplicationFiled: October 6, 2003Publication date: April 28, 2005Inventors: Marvin Siegel, N. Chu, Lee Mizzen
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Publication number: 20040235741Abstract: Disclosed is a method of treating a wart in a subject by administering to the subject a composition containing (1) a heat shock protein or an immunostimulatory fragment thereof, and (2) a protein of a human papilloma virus or an antigenic fragment thereof. Also disclosed is a method of treating a human papilloma virus infection in a subject infected or suspected of being infected with a human papilloma virus of a first type by administering to the subject a composition containing (1) a heat shock protein or an antigenic fragment thereof, and (2) a protein of a human papilloma virus of a second type or an antigenic fragment thereof, where the first type and second type are different.Type: ApplicationFiled: June 18, 2004Publication date: November 25, 2004Applicant: Stressgen Biotechnologies Corporation, a Canadian corporationInventors: John R. Neefe, Stephen E. Goldstone, Mark T. Winnett, Marvin Siegel, Leslie J. Boux
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Patent number: 6797491Abstract: Disclosed is a method of treating a wart in a subject by administering to the subject a composition containing (1) a heat shock protein or an immunostimulatory fragment thereof, and (2) a protein of a human papilloma virus or an antigenic fragment thereof. Also disclosed is a method of treating a human papilloma virus infection in a subject infected or suspected of being infected with a human papilloma virus of a first type by administering to the subject a composition containing (1) a heat shock protein or an antigenic fragment thereof, and (2) a protein of a human papilloma virus of a second type or an antigenic fragment thereof, where the first type and second type are different.Type: GrantFiled: February 13, 2003Date of Patent: September 28, 2004Assignee: Stressgen Biotechnologies CorporationInventors: John R. Neefe, Stephen E. Goldstone, Mark T. Winnett, Marvin Siegel, Leslie J. Boux
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Patent number: 6657055Abstract: The invention provides compositions and methods for stimulating a Th1-like response in vitro. Compositions include fusion proteins and conjugates that contain at least a portion of a heat shock protein. A Th1-like response can be elicited by contacting in vitro a cell sample containing naive lymphocytes with a fusion protein or conjugate of the invention. The Th1-like response can be detected by measuring IFN-gamma produced by the cell sample.Type: GrantFiled: October 9, 2002Date of Patent: December 2, 2003Assignee: Stressgen Biotechnologies CorporationInventors: Marvin Siegel, N. Randall Chu, Lee A. Mizzen
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Publication number: 20030170268Abstract: Disclosed is a method of treating a wart in a subject by administering to the subject a composition containing (1) a heat shock protein or an immunostimulatory fragment thereof, and (2) a protein of a human papilloma virus or an antigenic fragment thereof. Also disclosed is a method of treating a human papilloma virus infection in a subject infected or suspected of being infected with a human papilloma virus of a first type by administering to the subject a composition containing (1) a heat shock protein or an antigenic fragment thereof, and (2) a protein of a human papilloma virus of a second type or an antigenic fragment thereof, where the first type and second type are different.Type: ApplicationFiled: February 13, 2003Publication date: September 11, 2003Applicant: Stressgen Biotechnologies Corporation, a Canadian corporationInventors: John R. Neefe, Stephen E. Goldstone, Mark T. Winnett, Marvin Siegel, Leslie J. Boux
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Publication number: 20030050469Abstract: The invention provides compositions and methods for stimulating a Th1-like response in vitro. Compositions include fusion proteins and conjugates that contain at least a portion of a heat shock protein. A Th1-like response can be elicited by contacting in vitro a cell sample containing naive lymphocytes with a fusion protein or conjugate of the invention. The Th1-like response can be detected by measuring IFN-gamma produced by the cell sample.Type: ApplicationFiled: October 9, 2002Publication date: March 13, 2003Applicant: Stressgen Biotechnologies Corporation, a Victoria, Canada corporationInventors: Marvin Siegel, N. Randall Chu, Lee A. Mizzen
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Patent number: 6495347Abstract: The invention provides compositions and methods for stimulating a Th1-like response in vitro. Compositions include fusion proteins and conjugates that contain at least a portion of a heat shock protein. A Th1-like response can be elicited by contacting in vitro a cell sample containing naive lymphocytes with a fusion protein or conjugate of the invention. The Th1-like response can be detected by measuring IFN-gamma produced by the cell sample.Type: GrantFiled: July 10, 2000Date of Patent: December 17, 2002Assignee: Stressgen Biotechnologies CorporationInventors: Marvin Siegel, N. Randall Chu, Lee A. Mizzen
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Publication number: 20020155434Abstract: The invention relates to HBV antigen-containing compositions that are useful in treating or preventing HBV infection. The content of the compositions can vary, as described herein, but the compositions comprise a stress protein, or a portion (e.g., a fragment) or derivative thereof, and an HBV antigen.Type: ApplicationFiled: February 5, 2002Publication date: October 24, 2002Inventors: Lee A. Mizzen, Marvin Siegel, Hongwei Liu
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Publication number: 20020110566Abstract: Disclosed is a method of treating a wart in a subject by administering to the subject a composition containing (1) a heat shock protein or an immunostimulatory fragment thereof, and (2) a protein of a human papilloma virus or an antigenic fragment thereof. Also disclosed is a method of treating a human papilloma virus infection in a subject infected or suspected of being infected with a human papilloma virus of a first type by administering to the subject a composition containing (1) a heat shock protein or an antigenic fragment thereof, and (2) a protein of a human papilloma virus of a second type or an antigenic fragment thereof, where the first type and second type are different.Type: ApplicationFiled: June 26, 2001Publication date: August 15, 2002Inventors: John R. Neefe, Stephen E. Goldstone, Mark T. Winnett, Marvin Siegel, Leslie J. Boux