Patents by Inventor Mary A. Ruth
Mary A. Ruth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240174653Abstract: The present invention relates to methods for treating patients with systemic sclerosis, comprising administering to a patient in need thereof a therapeutically effective amount of a soluble guanylate cyclase (sGC) activator of formula (I), or a pharmaceutically acceptable salt thereof, where R1-R7 and A are as defined herein.Type: ApplicationFiled: November 2, 2023Publication date: May 30, 2024Inventors: Mary Ruth FLACK, Julia KAUFMAN, Indra SETHY-CORACI
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Publication number: 20220010022Abstract: The present invention provides methods for treating, preventing or ameliorating atopic dermatitis (AtD). In certain embodiments, the invention provides methods to reduce skin infection in a patient with atopic dermatitis. The methods of the present invention include administering to a patient in need thereof a pharmaceutical composition including an anti-interleukin-36 receptor (anit-IL-36R) antibody.Type: ApplicationFiled: May 17, 2021Publication date: January 13, 2022Inventors: Mary Ruth FLACK, Jay FINE, Janine LAMAR, Steven John PADULA, Chandrasena Reddy PAMULAPATI, Meera RAMANUJAM, Ralf SIGMUND, Sudha VISVANATHAN, Elizabeta ZOVKO
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Publication number: 20200308271Abstract: This invention generally relates to methods for the treatment of IL-23 related diseases, in particular inflammatory diseases, such as psoriasis or psoriatic arthritis, utilizing anti-IL-23A antibodies.Type: ApplicationFiled: December 21, 2019Publication date: October 1, 2020Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Patrick BAUM, Mary Ruth Flack, Annette Bettina Galler, Bojan Lalovic, Kaori Maino, Steven John Padula, Paul Scholl, Koji Sha, Sudha Visvanathan
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Patent number: 10766180Abstract: A micro-voided film comprising high density polyethylene having a molecular weight of at least about 200,000, and low aspect ratio filler having a mean particle size from about 1 to about 25 microns. The film has a thickness of from about 10 to about 75 microns and a void fraction of from about 0.60 to about 0.75. The micro-voided film is made by a process comprising extruding the composition into a film having a thickness of from about 50 to about 300 microns, and orienting the extruded film using a high stalk, blown film process. The process produces a stabilized high stalk for increasing the production rate of blown, high molecular weight polyethylene, while increasing the film's physical and mechanical properties. The high stalk can be stabilized by application of high velocity, low volume flow rate of air over the interior and exterior surfaces of the extruded film.Type: GrantFiled: May 31, 2018Date of Patent: September 8, 2020Assignee: GREENROCK, LTD.Inventors: Mary Ruth Lehrter, Adam Pacelli
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Patent number: 10202410Abstract: The present disclosure relates to scaphopetalone analogs, methods of making the analogs, and their uses.Type: GrantFiled: September 30, 2016Date of Patent: February 12, 2019Assignee: Brigham Young UniversityInventors: Merritt B. Andrus, F. Brent Johnson, Mary Ruth Jaeger Greer, Rex G. Cates
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Publication number: 20180272589Abstract: A micro-voided film comprising high density polyethylene having a molecular weight of at least about 200,000, and low aspect ratio filler having a mean particle size from about 1 to about 25 microns. The film has a thickness of from about 10 to about 75 microns and a void fraction of from about 0.60 to about 0.75. The micro-voided film is made by a process comprising extruding the composition into a film having a thickness of from about 50 to about 300 microns, and orienting the extruded film using a high stalk, blown film process. The process produces a stabilized high stalk for increasing the production rate of blown, high molecular weight polyethylene, while increasing the film's physical and mechanical properties. The high stalk can be stabilized by application of high velocity, low volume flow rate of air over the interior and exterior surfaces of the extruded film.Type: ApplicationFiled: May 31, 2018Publication date: September 27, 2018Inventors: Mary Ruth LEHRTER, Adam PACELLI
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Patent number: 10011063Abstract: A micro-voided film comprising high density polyethylene having a molecular weight of at least about 200,000, and low aspect ratio filler having a mean particle size from about 1 to about 25 microns. The film has a thickness of from about 10 to about 75 microns and a void fraction of from about 0.60 to about 0.75. The micro-voided film is made by a process comprising extruding the composition into a film having a thickness of from about 50 to about 300 microns, and orienting the extruded film using a high stalk, blown film process. The process produces a stabilized high stalk for increasing the production rate of blown, high molecular weight polyethylene, while increasing the film's physical and mechanical properties. The high stalk can be stabilized by application of high velocity, low volume flow rate of air over the interior and exterior surfaces of the extruded film.Type: GrantFiled: November 17, 2014Date of Patent: July 3, 2018Assignee: GREENROCK, LTD.Inventors: Mary Ruth Lehrter, Adam Pacelli
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Publication number: 20180099798Abstract: Provided herein are packaging materials that include a non-foamed layer and a foamed layer including a polyethylene.Type: ApplicationFiled: October 10, 2017Publication date: April 12, 2018Applicant: Sugar Creek Packing Co.Inventor: Mary Ruth Lehrter
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Publication number: 20170298126Abstract: This invention generally relates to methods for the treatment of IL-23 related diseases, in particular inflammatory diseases, such as psoriasis or psoriatic arthritis, utilizing anti-IL-23A antibodies.Type: ApplicationFiled: April 13, 2017Publication date: October 19, 2017Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Patrick BAUM, Mary Ruth FLACK, Annette Bettina GALLER, Bojan LALOVIC, Kaori MAINO, Steven John PADULA, Paul SCHOLL, Koji SHA, Sudha VISVANATHAN
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Patent number: 9676131Abstract: A micro-voided film comprising high density polyethylene having a molecular weight of at least about 200,000, and low aspect ratio filler having a mean particle size from about 1 to about 25 microns. The film has a thickness of from about 0.1 to about 20 mils and a void fraction of from about 0.60 to about 0.75. The micro-voided film is made by a process comprising extruding the composition into a film having a thickness of from about 20 to about 200 mils, and orienting the extruded film using a high stalk, blown film process. The process produces a stabilized high stalk for increasing the production rate of blown, high molecular weight polyethylene, while increasing the film's physical and mechanical properties. The high stalk can be stabilized by application of high velocity, low volume flow rate of air over the interior and exterior surfaces of the extruded film.Type: GrantFiled: January 15, 2015Date of Patent: June 13, 2017Assignee: Greenrock, Ltd.Inventors: Mary Ruth Lehrter, Adam Pacelli
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Publication number: 20170152280Abstract: The present disclosure relates to scaphopetalone analogs, methods of making the analogs, and their uses.Type: ApplicationFiled: September 30, 2016Publication date: June 1, 2017Inventors: Merritt B. Andrus, F. Brent Johnson, Mary Ruth Jaeger Greer, Rex G. Cates
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Publication number: 20160222102Abstract: This invention generally relates to methods for the treatment of IL-23 related diseases, in particular inflammatory diseases, such as psoriasis, psoriatic arthritis or axial (spinal) spondyloarthritis (ax-SpA), including ankylosing spondylitis and non-radiographic ax-SpA, utilizing anti-IL-23A antibodies.Type: ApplicationFiled: February 2, 2016Publication date: August 4, 2016Inventors: Matthias ARNDT, Stella ASLANYAN, Mary Ruth FLACK, Annette Bettina GALLER, Bojan LALOVIC, Steven John PADULA, Paul Russell SCHOLL
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Publication number: 20150123302Abstract: A micro-voided film comprising high density polyethylene having a molecular weight of at least about 200,000, and low aspect ratio filler having a mean particle size from about 1 to about 25 microns. The film has a thickness of from about 0.1 to about 20 mils and a void fraction of from about 0.60 to about 0.75. The micro-voided film is made by a process comprising extruding the composition into a film having a thickness of from about 20 to about 200 mils, and orienting the extruded film using a high stalk, blown film process. The process produces a stabilized high stalk for increasing the production rate of blown, high molecular weight polyethylene, while increasing the film's physical and mechanical properties. The high stalk can be stabilized by application of high velocity, low volume flow rate of air over the interior and exterior surfaces of the extruded film.Type: ApplicationFiled: January 15, 2015Publication date: May 7, 2015Inventors: Mary Ruth LEHRTER, Adam Pacelli
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Publication number: 20150072131Abstract: A micro-voided film comprising high density polyethylene having a molecular weight of at least about 200,000, and low aspect ratio filler having a mean particle size from about 1 to about 25 microns. The film has a thickness of from about 10 to about 75 microns and a void fraction of from about 0.60 to about 0.75. The micro-voided film is made by a process comprising extruding the composition into a film having a thickness of from about 50 to about 300 microns, and orienting the extruded film using a high stalk, blown film process. The process produces a stabilized high stalk for increasing the production rate of blown, high molecular weight polyethylene, while increasing the film's physical and mechanical properties. The high stalk can be stabilized by application of high velocity, low volume flow rate of air over the interior and exterior surfaces of the extruded film.Type: ApplicationFiled: November 17, 2014Publication date: March 12, 2015Inventors: Mary Ruth LEHRTER, Adam PACELLI
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Patent number: 8889047Abstract: A micro-voided film comprising high density polyethylene having a molecular weight of at least about 200,000, and low aspect ratio filler having a mean particle size from about 1 to about 25 microns. The film has a thickness of from about 10 to about 75 microns and a void fraction of from about 0.60 to about 0.75. The micro-voided film is made by a process comprising extruding the composition into a film having a thickness of from about 50 to about 300 microns, and orienting the extruded film using a high stalk, blown film process. The process produces a stabilized high stalk for increasing the production rate of blown, high molecular weight polyethylene, while increasing the film's physical and mechanical properties. The high stalk can be stabilized by application of high velocity, low volume flow rate of air over the interior and exterior surfaces of the extruded film.Type: GrantFiled: January 11, 2011Date of Patent: November 18, 2014Assignee: Greenrock, Ltd.Inventors: Mary Ruth Lehrter, Adam Pacelli
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Publication number: 20110171449Abstract: A micro-voided film comprising high density polyethylene having a molecular weight of at least about 200,000, and low aspect ratio filler having a mean particle size from about 1 to about 25 microns. The film has a thickness of from about 10 to about 75 microns and a void fraction of from about 0.60 to about 0.75. The micro-voided film is made by a process comprising extruding the composition into a film having a thickness of from about 50 to about 300 microns, and orienting the extruded film using a high stalk, blown film process. The process produces a stabilized high stalk for increasing the production rate of blown, high molecular weight polyethylene, while increasing the film's physical and mechanical properties. The high stalk can be stabilized by application of high velocity, low volume flow rate of air over the interior and exterior surfaces of the extruded film.Type: ApplicationFiled: January 11, 2011Publication date: July 14, 2011Inventors: Mary Ruth LEHRTER, Adam Pacelli
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Patent number: 7671024Abstract: The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. The application is related to OBG3 polypepide fragments and compositions comprising these fragments. It also discloses methods of reducing free fatty acid levels with the polypeptide fragments of the invention.Type: GrantFiled: May 23, 2008Date of Patent: March 2, 2010Assignee: Serono Genetics Institute S.A.Inventors: Joachim Fruebis, Mary Ruth Erickson, Frances Yen-Potin, Bernard Bihain
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Publication number: 20090099076Abstract: The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, globular OBG3, has been identified that reduces weight gain in animals. This compound should be effective for reducing body mass and for treating obesity-related diseases and disorders. These obesity-related diseases and disorders include hyperlipidermias, atherosclerosis, diabetes, and hypertension.Type: ApplicationFiled: May 23, 2008Publication date: April 16, 2009Applicant: Serono Genetics Institute S.A.Inventors: Joachim Fruebis, Mary Ruth Erickson, Frances Yen-Potin, Bernard Bihain
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Patent number: 7470669Abstract: The present invention is drawn to methods of screening for new compounds for the treatment of obesity and obesity-related diseases and disorders, as well as methods of treating obesity-related diseases and disorders, based on the discovery of the role of the leptin-LSR interaction in obesity.Type: GrantFiled: September 27, 2005Date of Patent: December 30, 2008Assignee: Serono Genetics Institute, S.A.Inventors: Frances Yen, Mary Ruth Erickson, Joachim Fruebis, Bernard Bihain
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Patent number: 7393661Abstract: The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. This application pertains to nucleic acids encoding a compound, globular OBG3 polypeptide fragments, vectors and transformed host cells containing these nucleic acids and methods of making the globular OBG3 polypeptide fragments.Type: GrantFiled: May 19, 2005Date of Patent: July 1, 2008Assignee: Serono Genetics Institute S.A.Inventors: Joachim Fruebis, Mary Ruth Erickson, Frances Yen-Potin, Bernard Bihain