Abstract: The invention relates to non-human transgenic animals expressing bioluminescent markers The invention provides a transgenic mouse whose genome comprises a nucleotide sequence encoding lucif erase, operably linked to murine control sequences whereby the lucif erase is expressed in all cells. Administration of a luciferin substrate to the mouse results in bioluminescence. The control sequence is the Rosa 26 promoter.

Abstract: An electrode assembly for implantation around an elongate biological structure such as, for example, a blood vessel, includes at least one belt mechanism for securing the electrode assembly around the outer surface of the elongate biological structure. Each of the at least one belt mechanism includes a strap and a buckle. The assembly has a length that is sufficient to permit wrapping it around the outer surface of the elongate biological structure. The buckle can be attached to, or integrally formed in, the base, and functions to retain a portion of the strap when the strap is engaged with the buckle.

Abstract: A method and device for providing stimulation to an artery for purposes of eliciting a physiologic response. A cuff having at least one electrode is provided, wherein the cuff is biased to conform to at least a portion of a vascular structure to maintain an intimate vascular structure-electrode interface. The device is selectively positioned proximate the effective position for providing stimulation to the vascular structure and the cuff is enabled to biasedly conform to at least a portion of the vascular structure. The cuff comprises includes resiliency enabling substantially normal pulsatile expansion of the artery while maintaining effective artery-electrode interface.

Abstract: Methods and apparatus for generating an electric field inside a patient include at least a first electrode and a second electrode on a common implantable substrate. Each of the electrodes has a respective proximal end and a respective distal end. Electrical energy can be applied that causes electrical current to flow simultaneously through the first and second electrodes preferentially from the proximal end of one electrode to the distal end of the other electrode.

Abstract: A method for predicting expected and unexpected loss outcomes for a portfolio of loans is provided. The loans are issued by a lender to a plurality of borrowers. The method includes recording key account and risk attributes for a historical portfolio of loans, recording actual default and loss information for each borrower included within the historical portfolio of loans, and comparing the key account and risk attributes with the actual default and loss information over a period of time.

Abstract: A medical electrical device that includes an elongated body extending from a proximal end to a distal end having an inner surface forming an elongated body lumen, a conductor extending through the elongated body lumen, and an electrode positioned along the distal end of the elongated body and electrically coupled to a distal end of the conductor. A connector ring is coupled to a proximal end of the elongated body and electrically coupled to a proximal end of the conductor, and includes an inner surface forming a connector ring lumen extending along the connector ring. A first flange extends from the inner surface to a first flange distal end and forms a conductor channel extending along the inner lumen to position the conductor within the connector ring and to form the electrical coupling of the connector ring and the proximal end of the conductor.

Abstract: Methods and apparatus for generating an electric field inside a patient include at least a first electrode and a second electrode on a common implantable substrate. Each of the electrodes has a respective proximal end and a respective distal end. Electrical energy can be applied that causes electrical current to flow simultaneously through the first and second electrodes preferentially from the proximal end of one electrode to the distal end of the other electrode.

Abstract: A method for enabling an existing business workflow tool to extend application functionality through the use of external components and for providing a business abstraction layer that lowers a user design barrier.

Abstract: Electrode structures for implantation include an electrode, an elastic backing attached to the electrode, and a sequestered drug on the backing or the electrode which is released to control and/or limit the growth of scar tissue. The elastic backing includes a tissue contacting side which contacts a tissue structure, and an exposed side away from the tissue contacting side. The electrode structure can be used to activate baroreceptors, and the backing is elastic and can stretch and retract with the tissue structure, for example the carotid sinus. The electrode and the sequestered drug can be positioned on the tissue contacting side so the drug is released near the electrode. The backing can be made from an insulating material and limit diffusion of the drug toward the exposed side, permitting scar tissue to grow near the exposed side to maintain positioning of the electrode.

Abstract: An implantable lead has a lead body construction designed to accommodate loading forces exerted on the lead body during patient movement. The lead body may be sufficiently stretchable to resist forces that could otherwise cause lead failure, axial migration of the electrodes, anchor damage, or tissue damage. Increasing stretchability of a lead body can also increase the vulnerability of the lead body to flex fatigue, buckling fatigue, kinking, and crush. Therefore, the lead described herein includes a coiled wire stylet guide to provide enhanced column strength. The coiled wire stylet guide may or may not be electrically conductive.

Abstract: An implantable electrical connector system, which may be used as part of an electrical lead, a connector block on an implantable pulse generator, or the connector of a lead extension. The distal most electrical contact on the proximal end of the lead (or lead extension) is adapted to provide registration or alignment of all of the electrical contacts of the proximal end of the lead (or lead extension) with electrical contacts of the distal connector of a lead extension or the electrical contacts of a connector block of an implantable pulse generator (IPG). In an exemplary embodiment, the distal most electrical contact on the proximal end portion of the lead may have a flange or shoulder that is adapted to engage the distal electrical contact of the female connection section of a lead extension or connector block. Most preferably, in this exemplary embodiment, the flange or shoulder is an integral part of the distal most electrical contact.

Abstract: A file folder edge reinforcement for the free edge of a file and having, and elongated reinforcement panel of flexible polyester film to overly the front and back sides of a free edge of the file, notches formed in the ends of the panel, an adhesive layer on the undersurface of the panel, an adhesive barrier backing panel releasably secured to the undersurface of the reinforcement panel, a fold line defined by an axis between the notches, along which the panel can be folded to overly both the front and back of the free edge of the file.

Abstract: Pyrimidine derivatives are provided wherein the 6-position carries the group OSO.sub.2 NR.sup.5 R.sup.6 and the 2-position carries the group NR.sup.1 R.sup.2. R.sup.1 and R.sup.2 are preferably hydrogen or lower alkyl but both are not hydrogen and R.sup.5 and R.sup.6 are preferably lower alkyl, although these groups may form a cyclic ring. The 3-position and 4-position are preferably substituted with lower alkyl, although lower alkynyl or alkenyl may be used. The derivatives are compounded into compositions for combatting fungal pests.