Abstract: The present disclosure provides a co-formulation that includes an antibody that binds specifically to C5 and a C5 iRNA which is a glycoconjugate that includes a ligand having terminal N-Acetylgalactosamine (GalNAc) residues and/or N-acetylglucosamine (GlcNAc) residues. Methods for reducing degradation of glycoconjugate RNA by beta-hexosaminidase enzyme are also provided. The present disclosure also includes methods for treating or preventing a C5-associated disease or disorder by administering one or more doses of an anti-C5 antibody or antigen-binding fragment thereof in combination with one or more doses of a C5 iRNA; preferably wherein the anti-C5 antibody or fragment and the C5 iRNA are in a co-formulation. The present disclosure also includes dosing regimens for treating C5-associated disease or disorder with a combination of anti-C5 antibody and C5 iRNA in subjects that either are treatment naïve or are switching from a previous C5 inhibitor therapy.

Abstract: The invention relates generally to a disposable household cleaning device and more specifically to disposable dustmop covers and broom covers. The present invention is made of soft, non-abrasive material to insure that the surface being cleaned is not scratched or otherwise harmed during the cleaning process. The present invention also avoids the need to launder dirty dust mop heads. The invention is designed to work in conjunction with commonly used household cleaning devices and employs individually exposable adhesive debris-retaining surfaces which assist in the efficient collection of dust and debris and which allow the invention to be reused several times before disposing of it.