Abstract: A method of producing a lenticular sheet having anisotropic optical properties comprising the steps of providing a body of transparent material having a pair of opposing sides and an index of refraction greater than one; forming a plurality of lenses on the first side of said pair of opposing sides in pre-selected portions of the first side; and wherein the remainder of the first side of said pair of opposing sides outside the pre-selected lens portions is generally flat and transparent. A method of manufacturing a lenticular sheet comprising the steps of producing a transparent sheet by engraving a desired lens pattern over an entire cylinder or flat plate; placing a mask over selected lens areas; metal plating the unmasked areas to a thickness greater than the surface of the masked areas; and cutting the plated areas back to the level of the masked areas.

Abstract: There is provide by the invention a method of diagnosing a human female suspected of being an symptomatic carrier of X-linked agammaglobulinemia (XLA). The method comprises sampling B cell lymphocytes of said female; and determining whether at least 95% of said B cell lymphocytes exhibit inactivation of the same chromosome; whereby said X chromosome inactivation is diagnostic of XLA. The invention further provides a method of screening a human female suspected of being an asymptomatic carrier of X-linked severe combined immunodeficiency (XSCID). The method comprises sampling the B or T cell lymphocytes of said female; determining whether at least 85% of said lymphocytes exhibit inactivation of the same chromosome; whereby said X chromosome inactivation is associated with XSCID.