Patents by Inventor Mary Jane Cunningham

Mary Jane Cunningham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and Biomarkers for Detecting Nanoparticle Exposure
    Publication number: 20080254459
    Abstract: Methods for gene expression profiling for exposure to nanoscale particulates or nanomaterials is provided together with identified biomarkers for nanomaterial exposure. A toxicogenomic exposure profile for nanomaterial contact is provided in accordance with a systems biology approach by iteratively sampling a test system several times after contact with nanomaterials of various chemical types.
    Type: Application
    Filed: March 6, 2006
    Publication date: October 16, 2008
    Applicant: (HARC) HOUSTON ADVANCED RESEARCH CENTER
    Inventor: Mary Jane Cunningham
  • Marker genes responding to treatment with toxins
    Publication number: 20030165854
    Abstract: The present invention relates to a combination comprising a plurality of cDNAs which are differentially expressed in treated rat liver and in human liver and which may be used in their entirety or in part to diagnose, stage, or treat a liver disorder, to monitor diagnostic and therapeutic applications, to detect metabolic and toxicological responses, and to elucidate drug mechanism of action.
    Type: Application
    Filed: December 5, 2001
    Publication date: September 4, 2003
    Inventors: Mary Jane Cunningham, Matthew R. Kaser
  • Toxicological response markers
    Patent number: 6403778
    Abstract: The present invention relates to a composition comprising a plurality of polynucleotide targets. The composition can be used as hybridizable array elements in a microarray. The present invention also relates to methods for screening compounds and therapeutic treatments for toxicological responses.
    Type: Grant
    Filed: August 28, 1998
    Date of Patent: June 11, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Mary Jane Cunningham, Gary B. Zweiger, Scott R. Panzer, Jeffrey J. Seilhamer
  • Mammalian toxicological response markers
    Patent number: 6372431
    Abstract: The present invention relates to mammalian nucleic acid and protein molecules comprising a plurality of nucleic acid and protein molecules. The mammalian nucleic acid molecules can be used as hybridizable array elements in a microarray in diagnostic and therapeutic applications including detecting metabolic and toxicological responses, and in monitoring drug mechanism of action. The protein molecules can be used in a pharmaceutical composition. The present invention also relates to methods for screening compounds and therapeutics for metabolic responses indicative of a toxic compound or molecule.
    Type: Grant
    Filed: November 19, 1999
    Date of Patent: April 16, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Mary Jane Cunningham, Gary B. Zweiger, Matthew R. Kaser, Scott R. Panzer, Jeffrey J. Seilhamer, Henry Yue, Mariah R. Baughn, Yalda Azimzai, Preeti Lal
  • Markers for peroxisomal proliferators
    Patent number: 6160104
    Abstract: The present invention relates to a composition comprising a plurality of polynucleotide targets. The composition can be used as hybridizable array elements in a microarray. The present invention also relates to methods for screening compounds and therapeutic treatments for toxicological responses.
    Type: Grant
    Filed: October 13, 1998
    Date of Patent: December 12, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Mary Jane Cunningham, Gary B. Zweiger, Scott R. Panzer, Jeffrey J. Seilhamer
  • Monitoring toxicological responses
    Patent number: 6160105
    Abstract: The present invention relates to a composition comprising a plurality of polynucleotide targets. The composition can be used as hybridizable array elements in a microarray. The present invention also relates to methods for screening compounds and therapeutic treatments for toxicological responses.
    Type: Grant
    Filed: October 13, 1998
    Date of Patent: December 12, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Mary Jane Cunningham, Gary B. Zweiger, Scott R. Panzer, Jeffrey J. Seilhamer