Abstract: Compositions and methods for treating neuronal injury, such as in Parkinson's disease, comprising administration of hematopoietic stem cells and mesenchymal stromal cells to a subject are provided. Methods for producing such compositions from blood, including umbilical cord blood are also provided.

Abstract: Methods for producing therapeutic T cells from umbilical cord blood are provided. Methods for treating immune-related diseases or conditions (e.g. autoimmune diseases, transplant rejection, cancer) using umbilical cord blood derived therapeutic T cells are also provided. Compositions comprising umbilical cord blood derived therapeutic T cells are also provided. Methods for treating diseases and methods for increasing or decreasing available ATP within a proliferating cell, through mitochondrial transfer induction or inhibition are also provided.

Abstract: Methods for isolating mesenchymal stromal cells from umbilical cord blood. The methods include providing a blood collection bag having raw umbilical cord blood contained therein, draining the umbilical cord blood from the blood collection bag, introducing a cell detachment solution into the blood collection bag to dissociate mesenchymal stromal cells adhered to the bag surface, thereby forming a mesenchymal stromal cell enriched fluid, and voiding the mesenchymal stromal cell enriched fluid into a collection apparatus for further processing and culturing.

Abstract: Methods for providing wound healing compositions that include umbilical cord blood derived monocytes and umbilical cord blood derived platelet rich plasma are provided. Methods for treating a non-healing wound in a subject by administration of a wound healing composition that includes umbilical cord blood derived monocytes and umbilical cord blood derived platelet rich plasma are provided.

Abstract: Methods for producing therapeutic T cells from umbilical cord blood are provided. Methods for treating immune-related diseases or conditions (e.g. autoimmune diseases, transplant rejection, cancer) using umbilical cord blood derived therapeutic T cells are also provided. Compositions comprising umbilical cord blood derived therapeutic T cells are also provided.

Abstract: Methods for providing allogeneic, immune-tolerant and virus-resistant umbilical cord blood cells are provided. Compositions and methods for treating a disease or condition in a subject by transplantation of allogeneic, immune-tolerant, and virus-resistant umbilical cord blood cells are provided. PCR-based methods for identifying donor cord blood having a CCR5 ?32 genotype conferring HIV-resistance are provided.

Abstract: A composition and method for stabilizing DNA in saliva at room temperature. The composition comprises a denaturing agent, a chelating agent, a biocide and trehalose in a gel formulation. Such a composition is re-hydrated upon contact with saliva. Also included are means for storing the composition.

Abstract: Apparatus and methods are provided to obtain RNA-enhanced and protein-enhanced fluid samples which are stable at ambient temperatures. An apparatus includes a filter element made from a fibrous hydrophilic material which preferentially binds and filters cells, DNA-containing macrostructures, mucins and particulates, but does not preferentially bind RNA, RNA-containing macrostructures or proteins. An apparatus may include a sample collector having an absorbent collection pad which also does not preferentially bind RNA, RNA-containing macrostructures or proteins. A method includes obtaining a sample and passing the sample through an RNA-and-protein-preferential filter element to obtain RNA-enhanced and protein-enhanced samples. The method may include use of a RNA-and-protein-preferential absorbent pad material to collect the sample. DNA-rich samples may be obtained by using DNA elution buffer to release the DNA-containing cells and macrostructures after obtaining the RNA-enhanced and protein-enhanced samples.

Abstract: The invention provides methods of inducing neovascularization in a subject in need thereof. The invention further provides compositions, devices and implantable products generated from conditioned media, and in particular, from conditioned media from cultured umbilical cord populations. These compositions are useful for inducing neovascularization. The invention also provides methods of distributing compositions, devices and products to health care professionals.

Abstract: The invention provides, among other things, methods for modulating NFATc2 and methods for treating graft versus host disease, transplant rejection, and other NFATc2-related disorders.

Abstract: The invention provides, among other things, methods for treating an ischemic tissue in a subject in need thereof. The invention further provides methods for increasing the blood flow to an ischemic tissue in a subject in need thereof, such as to ischemic myocardium. The invention further provides cell-based formulations and related kits.