Patents by Inventor Mary Margaret Bendig

Mary Margaret Bendig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reshaped human antibody to human interleukin-6 receptor
    Patent number: 7479543
    Abstract: A reshaped human antibody to the human IL-6R, comprising: (A) an L chain comprising, (1) a human L chain C region, and (2) an L chain V region comprising human L chain framework regions (FRs), and mouse L chain complementary determination regions (CDRs) of a momoclonal antibody to the IL-6 receptor (IL-6R); and (B) an H chain comprising, (1) a human H chain C region, and (2) an H chain V region comprising human H chain FRS, and mouse H chain CDRs of a monoclonal antibody to the IL-6R. Since major portion of the reshaped human antibody is derived from a human antibody and the mouse CDRs which are less immunogenic, the present reshaped human antibody is less immunogenic to human, and therefor is promised for therapeutic uses.
    Type: Grant
    Filed: May 4, 2004
    Date of Patent: January 20, 2009
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Masayuki Tsuchiya, Koh Sato, Mary Margaret Bendig, Steven Tarran Jones, Jose William Saldanha
  • Reshaped human antibody to human interleukin-6 receptor
    Publication number: 20050142635
    Abstract: A reshaped human antibody to the human IL-6R, comprising: (A) an L chain comprising, (1) a human L chain C region, and (2) an L chain V region comprising human L chain framework regions (FRs), and mouse L chain complementary determination regions (CDRs) of a momoclonal antibody to the IL-6 receptor (IL-6R); and (B) an H chain comprising, (1) a human H chain C region, and (2) an H chain V region comprising human H chain FRS, and mouse H chain CDRs of a monoclonal antibody to the IL-6R. Since major portion of the reshaped human antibody is derived from a human antibody and the mouse CDRs which are less immunogenic, the present reshaped human antibody is less immunogenic to human, and therefor is promised for therapeutic uses.
    Type: Application
    Filed: May 4, 2004
    Publication date: June 30, 2005
    Inventors: Masayuki Tsuchiya, Koh Sato, Mary Margaret Bendig, Steven Tarran Jones, Jose Saldanha
  • Reshaped human antibody to human interleukin-6 receptor
    Patent number: 5817790
    Abstract: A reshaped human antibody to the human IL-6R, comprising:(A) an L chain comprising,(1) a human L chain C region, and(2) an L chain V region comprising human L chain framework regions (FRs), and mouse L chain complementary determination regions (CDRs) of a monoclonal antibody to the IL-6 receptor (IL-6R); and(B) an H chain comprising,(1) a human H chain C region, and(2) an H chain V region comprising human H chain FRs, and mouse H chain CDRs of a monoclonal antibody to the IL-6R.Since major portion of the reshaped human antibody is derived from a human antibody and the mouse CDRs which are less immunogenic, the present reshaped human antibody is less immunogenic to human, and therefor is promised for therapeutic uses.
    Type: Grant
    Filed: May 8, 1995
    Date of Patent: October 6, 1998
    Assignee: Chugai Seiyaku Kabushiki
    Inventors: Masayuki Tsuchiya, Koh Sato, Mary Margaret Bendig, Steven Tarran Jones, Jose William Saldanha
  • Reshaped human to human interleukin-6 receptor
    Patent number: 5795965
    Abstract: A reshaped human antibody to the human IL-6R, comprising:(A) an L chain comprising,(1) a human L chain C region, and(2) an L chain V region comprising human L chain framework regions (FRs), and mouse L chain complementary determination regions (CDRS) of a momoclonal antibody to the IL-6 receptor (IL-6R); and(B) an H chain comprising,(1) a human H chain C region, and(2) an H chain V region comprising human H chain FRs, and mouse H chain CDRs of a monoclonal antibody to the IL-6R.Since major portion of the reshaped human antibody is derived from a human antibody and the mouse CDRs which are less immunogenic, the present reshaped human antibody is less immunogenic to human, and therefor is promised for therapeutic uses.
    Type: Grant
    Filed: December 20, 1993
    Date of Patent: August 18, 1998
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Masayuki Tsuchiya, Koh Sato, Mary Margaret Bendig, Steven Tarran Jones, Jose William Saldanha