Patents by Inventor Mary McGrane

Mary McGrane has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dietary and hormonal regulation of expression of exogenous genes in transgenic animals under control of the promoter of the gene for phosphoenolpyruvate carboxykinase
    Patent number: 5075229
    Abstract: A transgenic animal is constructed in which one or more cells contain a promoter to the gene for cytosolic PEPCK operably linked to a non-PEPCK gene of interest. Expression of this gene is controlled by modifying the protein and carbohydrate components of the animal's diet, or by direct hormonal regulation. The PEPCK promoter is induced by high protein and inhibited by high carbohydrate, or more directly by cAMP and insulin. The linked gene is expressed essentially only after bith and essentially only in particular tissues. The PEPCK promoter has a extremely high promoter strength.
    Type: Grant
    Filed: June 13, 1988
    Date of Patent: December 24, 1991
    Assignee: Ohio University Edison Animal Biotechnology Center
    Inventors: Richard W. Hanson, Mary McGrane, Jay Short, Maria Hatzoglou