Abstract: The present invention provides a method and system for improving patient compliance to prescribed therapeutic regimens by allowing the patient to participate in a system, the system being firstly authorized by the patient to initiate communication with the patient should the patient become non-compliant with the prescribed regimen. The system initiates communication with non-compliant patients through means that may include telephone, facsimile, electronic mail, text messaging, RFID, and Bluetooth®, but will not contact those users adhering to the prescribed regimen. Those users adhering to the prescribed regimen, therefore, may report compliance actively (e.g., notifying the system of compliance, thereby preventing communication from the system) or passively (e.g., through high frequency communications from sensors monitoring compliance, thereby preventing communication from the system).