Patents by Inventor Mary S. Kleppe

Mary S. Kleppe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INTRANASAL ADMINISTRATION OF RAPID ACTING INSULIN
    Publication number: 20100210506
    Abstract: What is described are pharmaceutical compositions, formulations, and uses thereof, for medicaments for intranasal delivery of insulin to a patient, comprising an aqueous mixture of human insulin, a solubilizing agent, and a surface active agent, wherein the human insulin may be rapid actin insulin.
    Type: Application
    Filed: October 20, 2006
    Publication date: August 19, 2010
    Applicant: MDRNA, INC.
    Inventors: Steven C. Quay, Annemarie Stoudt Cohen, Henry R. Costantino, Shu-Chih Chen Quay, Anthony P. Sileno, Mary S. Kleppe
  • COMPOSITIONS AND METHODS FOR ENHANCED MUCOSAL DELIVERY OF PARATHYROID HORMONE
    Publication number: 20100184688
    Abstract: Pharmaceutical compositions and methods are described comprising at least a parathyroid hormone peptide (PTH) preferably PTH1-34 and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of PTH, for treating or preventing osteoporosis or osteopenia in a mammalian subject, preferably a human.
    Type: Application
    Filed: March 17, 2010
    Publication date: July 22, 2010
    Applicant: MDRNA, INC.
    Inventors: Steven C. Quay, Henry R. Costantino, Mary S. Kleppe, Ching-Yuan Li
  • FORMULATIONS FOR ENHANCED MUCOSAL DELIVERY OF PYY
    Publication number: 20090054326
    Abstract: Pharmaceutical formulations are described for enhancing mucosal delivery of peptide YY (PYY) to a mammal. A PYY dosage form is described that is suitable for multi-use administration. The PYY dosage form comprises a bottle containing an aqueous pharmaceutical formulation and an actuator effective intranasal administration of the formulation. The formulation comprises a therapeutically effective amount of PYY, a buffer to control pH, a water-miscible polar organic solvent and a chelating agent for cations. The PYY dosage form exhibits at least 90% PYY recovery after storage as used for greater than about five days.
    Type: Application
    Filed: July 10, 2006
    Publication date: February 26, 2009
    Applicant: NASTECH PHARMACEUTICAL COMPANY INC.
    Inventors: Henry R. Costantino, Mary S. Kleppe, Annemarie S. Cohen, Anthony P. Sileno
  • TRANSMUCOSAL DELIVERY OF PEPTIDE DERIVATIVES
    Publication number: 20090042790
    Abstract: What is described is a biological agent, comprised of a biologically active protein, or a fragment or a mimetic thereof, conjugated to at least one poly(alkylene oxide) chain having a size less than about 20 kDa, pharmaceutical formulations for intranasal delivery of said biological agent, or uses of said biological agent in the manufacture of said pharmaceutical formulation for administering said biological agent to a mammal.
    Type: Application
    Filed: June 13, 2006
    Publication date: February 12, 2009
    Applicant: NASTECH PHARMACEUTICAL COMPANY INC.
    Inventors: Henry R. Costantino, Mary S. Kleppe, Ching-Yuan Li
  • Pharmaceutical Formation For Increased Epithelial Permeability of Glucose-Regulating Peptide
    Publication number: 20080318837
    Abstract: What is described is a pharmaceutical formulation comprising a mixture of a pharmaceutically effective amount of glucose-regulating peptide (GRP) and enhancers, wherein the pharmaceutical formulation is used in the treatment of a metabolic syndrome.
    Type: Application
    Filed: December 1, 2006
    Publication date: December 25, 2008
    Applicant: NASTECH PHARMACEUTICAL COMPANY INC.
    Inventors: Steven C. Quay, Henry R. Costantino, Michael V. Templin, Alexis Kays Leonard, Mary S. Kleppe, Joshua O. Sestak
  • Compositions and methods for enhanced mucosal delivery of parathyroid hormone
    Patent number: 7435720
    Abstract: Pharmaceutical compositions and methods are described comprising at least a parathyroid hormone peptide (PTH) preferably PTH1-34 and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of PTH, for treating or preventing osteoporosis or osteopenia in a mammalian subject, preferably a human.
    Type: Grant
    Filed: October 17, 2006
    Date of Patent: October 14, 2008
    Assignee: MDRNA, Inc.
    Inventors: Steven C. Quay, Henry R. Costantino, Mary S. Kleppe, Ching-Yuan Li
  • Compositions and methods for enhanced mucosal delivery of parathyroid hormone
    Patent number: 7244709
    Abstract: Pharmaceutical compositions and methods are described comprising at least a parathyroid hormone peptide (PTH) preferably PTH1-34 and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of PTH, for treating or preventing osteoporosis or osteopenia in a mammalian subject, preferably a human.
    Type: Grant
    Filed: May 10, 2005
    Date of Patent: July 17, 2007
    Assignee: Nastech Pharamecutical Company Inc.
    Inventors: Steven C. Quay, Henry R. Costantino, Mary S. Kleppe, Ching-Yuan Li
  • Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity
    Patent number: 7229966
    Abstract: Pharmaceutical compositions and methods are described comprising at least one Y2 receptor-binding peptide, such as peptide YY(PYY), Neuropeptide Y (NPY) or Pancreatic Peptide (PP) and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of the peptide YY, for treating a variety of diseases and conditions in mammalian subjects, including obesity.
    Type: Grant
    Filed: February 17, 2004
    Date of Patent: June 12, 2007
    Assignee: Nastech Pharmaceutical Company Inc.
    Inventors: Steven C. Quay, Gordon Brandt, Mary S. Kleppe, Conor J. MacEvilly
  • Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity
    Patent number: 7186691
    Abstract: Pharmaceutical compositions and methods are described comprising at least one Y2 receptor-binding peptide, such as peptide YY(PYY), Neuropeptide Y (NPY) or Pancreatic Peptide (PP) and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of the peptide YY, for treating a variety of diseases and conditions in mammalian subjects, including obesity.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: March 6, 2007
    Assignee: Nastech Pharmaceutical Company Inc.
    Inventors: Steven C. Quay, Gordon Brandt, Mary S. Kleppe, Conor J. MacEvilly
  • Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity
    Patent number: 7157426
    Abstract: Pharmaceutical compositions and methods are described comprising at least one Y2 receptor-binding peptide, such as peptide YY(PYY), Neuropeptide Y (NPY) or Pancreatic Peptide (PP) and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of the peptide YY, for treating a variety of diseases and conditions in mammalian subjects, including obesity.
    Type: Grant
    Filed: January 30, 2004
    Date of Patent: January 2, 2007
    Assignee: Nastech Pharmaceutical Company Inc.
    Inventors: Steven C. Quay, Gordon Brandt, Mary S. Kleppe, Conor J. MacEvilly
  • Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity
    Publication number: 20040214772
    Abstract: Pharmaceutical compositions and methods are described comprising at least one Y2 receptor-binding peptide, such as peptide YY(PYY), Neuropeptide Y (NPY) or Pancreatic Peptide (PP) and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of the peptide YY, for treating a variety of diseases and conditions in mammalian subjects, including obesity.
    Type: Application
    Filed: February 17, 2004
    Publication date: October 28, 2004
    Applicant: Nastech Pharmaceutical Company Inc.
    Inventors: Steven C. Quay, Gordon Brandt, Mary S. Kleppe, Conor J. MacEvilly
  • Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity
    Publication number: 20040209807
    Abstract: Pharmaceutical compositions and methods are described comprising at least one Y2 receptor-binding peptide, such as peptide YY(PYY), Neuropeptide Y (NPY) or Pancreatic Peptide (PP) and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of the peptide YY, for treating a variety of diseases and conditions in mammalian subjects, including obesity.
    Type: Application
    Filed: January 30, 2004
    Publication date: October 21, 2004
    Applicant: Nastech Pharmaceutical Company Inc.
    Inventors: Steven C. Quay, Gordon Brandt, Mary S. Kleppe, Conor J. MacEvilly
  • Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity
    Publication number: 20040157777
    Abstract: Pharmaceutical compositions and methods are described comprising at least one Y2 receptor-binding peptide, such as peptide YY(PYY), Neuropeptide Y (NPY) or Pancreatic Peptide (PP) and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of the peptide YY, for treating a variety of diseases and conditions in mammalian subjects, including obesity.
    Type: Application
    Filed: December 23, 2003
    Publication date: August 12, 2004
    Applicant: Nastech Pharmaceutical Company Inc.
    Inventors: Steven C. Quay, Gordon Brandt, Mary S. Kleppe, Conor J. MacEvilly