Patents by Inventor Maryann B. Gray

Maryann B. Gray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Expression of lipoproteins
    Patent number: 6538118
    Abstract: Heterologous lipidated proteins formed recombinantly are disclosed and claimed. The expression system can be E. coli. The heterologous lipidated protein has a leader sequence which does not naturally occur with the protein portion of the lipidated protein. The lipidated protein can have the Borrelia OspA leader sequence. The protein portion can be OspC, PspA, UreA, Ure B, or a fragment thereof. Methods and compositions for forming and employing the proteins are also disclosed and claimed.
    Type: Grant
    Filed: April 28, 1998
    Date of Patent: March 25, 2003
    Assignee: Connaught Laboratories, Inc.
    Inventors: Robert C. Huebner, Lorne F. Erdile, Donald J. Warakomski, Jr., Robert S. Becker, Maryann B. Gray, Derek J. Pyle
  • Immunological combination compositions and methods
    Patent number: 6251405
    Abstract: Immunological compositions and methods for making and using them. The compositions contain an antigen and a lipoprotein and optionally an adjuvant. The lipoprotein can itself be antigenic or immurogenic. The antigen can be influenza HA and the lipoprotein a recombinantly expressed product having an OspA leader for lipidation and PspA for the protein portion. The antigen can be OspC and the lipoprotein OspA. The components of the composition are co-administered. A potentiated immunological response is obtained by the compositions and methods.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 26, 2001
    Assignee: Connaught Laboratories, Inc.
    Inventors: Robert S. Becker, Robert C. Huebner, Maryann B. Gray, Karen S. Biscardi