Patents by Inventor Maryanne J. Little

Maryanne J. Little has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mass spectrometric methods for sequencing nucleic acids
    Patent number: 6268131
    Abstract: A mass spectrometric method for sequencing nucleic acids using RNA polymerases, including DNA-dependent and RNA-dependent RNA polymerases, is provided. The methods use a modified Sanger sequencing strategy in which RNA polymerase is used to generate a set of nested RNA transcripts obtained by base-specific chain termination. These are analyzed by mass spectrometry. A method of identifying transcriptional terminator sequences or attenuator sequences is also provided.
    Type: Grant
    Filed: December 15, 1997
    Date of Patent: July 31, 2001
    Assignee: Sequenom, Inc.
    Inventors: Changwon Kang, Young-Soo Kwon, Young Tae Kim, Hubert Köster, Daniel P. Little, Maryanne J. Little, Guobing Xiang, David M. Lough, Charles Cantor