Patents by Inventor Masaaki Uenaka
Masaaki Uenaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140012013Abstract: Disclosed is a process for producing a pyrazole carboxylic acid derivative which is useful as a significant intermediate of an 11?HSD-1 inhibitor. A compound represented by the Formula (XI): is useful as a significant intermediate of an 11?HSD-1 inhibitor, wherein R1 and R2 are each independently hydrogen or substituted or unsubstituted alkyl, R3 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocyclyl and R4 is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocyclyl.Type: ApplicationFiled: March 15, 2012Publication date: January 9, 2014Applicant: SHIONOGI & CO., LTD.Inventors: Masaaki Uenaka, Shuji Yonezawa, Akira Iida, Mutsumi Takaki, Tomoyuki Ogawa, Satoshi Goda, Yoshikatsu Hirose, Tomohiro Fukuda
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Publication number: 20110224425Abstract: An object of the present invention is to provide a carbapenem synthetic intermediate which is advantageous in an industrial process. There are provided a process for producing Compound (I), or a pharmaceutically acceptable salt, or a solvate, or a crystal thereof, comprising reacting Compound (III) and Compound (IV) in the presence of the secondary amine, and a benzyl alcoholated crystal of Compound (I). There are further provided a method of deprotecting Compound (I) with a Pd catalyst, and a crystal of Compound (IV).Type: ApplicationFiled: March 21, 2011Publication date: September 15, 2011Inventors: Masaaki UENAKA, Yasuyuki HOZUMI, Kouichi NOGUCHI, Tadafumi KOMURASAKI
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Patent number: 7795471Abstract: The present invention relates to a process for preparing a compound of the formula: wherein R1 is lower alkyl, R4 is hydrogen or lower alkyl, and Z is optionally substituted lower alkyl, optionally substituted lower alkenly, optionally substituted amino, optionally substituted lower alkoxy, optionally substituted carbocyclyl or optionally substituted heterocyclyl.Type: GrantFiled: May 11, 2009Date of Patent: September 14, 2010Assignee: Shionogi & Co., Ltd.Inventors: Yasuyuki Kawanishi, Masaaki Uenaka, Munenori Matsuura
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Patent number: 7767809Abstract: The disclosed invention relates to a solvate of the compound (I) of the formula: or a crystal thereof.Type: GrantFiled: February 12, 2004Date of Patent: August 3, 2010Assignee: Shionogi & Co., Ltd.Inventor: Masaaki Uenaka
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Publication number: 20090221817Abstract: A process for the preparation of Compound (I) comprising reacting Compound (II) with a base in an aprotic solvent, which is represented by the following scheme: wherein R1 and R2 are each independently lower alkyl.Type: ApplicationFiled: May 11, 2009Publication date: September 3, 2009Applicant: Shionogi & Co., Ltd.Inventors: Yasuyuki KAWANISHI, Masaaki Uenaka, Munenori Matsuura
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Patent number: 7547800Abstract: A process for the preparation of Compound (I) comprising reacting Compound (II) with a base in an aprotic solvent, which is represented by the following scheme: wherein R1 and R2 are each independently lower alkyl.Type: GrantFiled: October 7, 2008Date of Patent: June 16, 2009Assignee: Shionogi & Co., Ltd.Inventors: Yasuyuki Kawanishi, Masaaki Uenaka, Munenori Matsuura
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Publication number: 20090043094Abstract: A process for the preparation of Compound (I) comprising reacting Compound (II) with a base in an aprotic solvent, which is represented by the following scheme: wherein R1 and R2 are each independently lower alkyl.Type: ApplicationFiled: October 7, 2008Publication date: February 12, 2009Applicant: Shionogi & Co., Ltd.Inventors: Yasuyuki KAWANISHI, Masaaki Uenaka, Munenori Matsuura
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Patent number: 7459580Abstract: A process for the preparation of Compound (I) comprising reacting Compound (II) with a base in an aprotic solvent, which is represented by the following scheme: wherein R1 and R2 are each independently lower alkyl.Type: GrantFiled: October 12, 2007Date of Patent: December 2, 2008Assignee: Shionogi & Co., Ltd.Inventors: Yasuyuki Kawanishi, Masaaki Uenaka, Munenori Matsuura
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Publication number: 20080171864Abstract: An object of the present invention is to provide a carbapenem synthetic intermediate which is advantageous in an industrial process. There are provided a process for producing Compound (I), or a pharmaceutically acceptable salt, or a solvate, or a crystal thereof, comprising reacting Compound (III) and Compound (IV) in the presence of the secondary amine, and a benzyl alcoholated crystal of Compound (I). There are further provided a method of deprotecting Compound (I) with a Pd catalyst, and a crystal of Compound (IV).Type: ApplicationFiled: February 14, 2006Publication date: July 17, 2008Inventors: Masaaki Uenaka, Yasuyuki Hozumi, Kouichi Noguchi, Tadafumi Komurasaki
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Publication number: 20080039662Abstract: A process for the preparation of Compound (I) comprising reacting Compound (II) with a base in an aprotic solvent, which is represented by the following scheme: wherein R1 and R2 are each independently lower alkyl.Type: ApplicationFiled: October 12, 2007Publication date: February 14, 2008Applicant: Shionogi & Co., Ltd.Inventors: Yasuyuki Kawanishi, Masaaki Uenaka, Munenori Matsuura
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Patent number: 7314950Abstract: A process for the preparation of Compound (I) comprising reacting Compound (II) with a base in an aprotic solvent, which is represented by the following scheme: wherein R1 and R2 are each independently lower alkyl.Type: GrantFiled: March 7, 2003Date of Patent: January 1, 2008Assignee: Shionogi & Co., Ltd.Inventors: Yasuyuki Kawanishi, Masaaki Uenaka, Munenori Matsuura
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Publication number: 20060229285Abstract: (Problem) A crystal of synthetic intermediates of carbapenem, which is useful for an industrial method for producing, is provided. (Means for Solution) A solvate of the compound (I) of the formula: or a crystal thereof.Type: ApplicationFiled: February 12, 2004Publication date: October 12, 2006Applicant: Shionogi & Co., Ltd.Inventor: Masaaki Uenaka
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Patent number: 7049437Abstract: The present invention provides a process of a compound of the formula (I): wherein R is heteroaryl or the like, ring A is a heteroalicyclic group or the like comprising reacting a compound of the formula (II): wherein Hal is halogen and the other symbols are the same as the above, in the presence of a sulfinic acid salt and further in the presence of an acid or a salt with an organic base, and a novel crystal form of 2-(3-isoxazolyl)-3,6,7,9-tetrahydroimidazo[4,5-d]pyrano[4,3-b]pyridine phosphate monohydrate.Type: GrantFiled: March 29, 2001Date of Patent: May 23, 2006Assignee: Shionogi & Co., Ltd.Inventors: Fumihiko Matsubara, Takashi Ohya, Masaaki Uenaka
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Publication number: 20050222255Abstract: A process for the preparation of Compound (I) comprising reacting Compound (II) with a base in an aprotic solvent, which is represented by the following scheme: wherein R1 and R2 are each independently lower alkyl.Type: ApplicationFiled: March 7, 2003Publication date: October 6, 2005Applicant: Shionogi & Co., Ltd.Inventors: Yasuyuki Kawanishi, Masaaki Uenaka, Munenori Matsuura
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Patent number: 6831177Abstract: Industrial and commercial processes for the preparation of 2-acyl-5-benzylfuran derivatives, 1,2,4-triazole-3-carboxylic acid ester derivatives or propenone derivatives having an anti-HIV activity; and useful crystals of the derivatives. A deblocking: (III-2), (IV-10), (VI-1), wherein R1, R2 and R4 are each independently hydrogen or the like; A is CR6 or N; R6 is hydrogen or the like; Q is a protecting group; and L is a leaving group.Type: GrantFiled: December 3, 2001Date of Patent: December 14, 2004Assignee: Shionogi & Co., Ltd.Inventors: Masaaki Uenaka, Kyozo Kawata, Masahiko Nagai, Takeshi Endoh
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Publication number: 20030088102Abstract: The present invention provides a process of a compound of the formula (I): 1Type: ApplicationFiled: September 25, 2002Publication date: May 8, 2003Inventors: Fumihiko Matsubara, Takashi Ohya, Masaaki Uenaka
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Patent number: 6506903Abstract: A process for the production of 4-thiazolylmethyl derivatives are provided. A process for the production of the compound represented by the formula (I): wherein R1 is hydrogen or halogen and Hal is halogen, which comprises reacting 4-methylthiazole with N-halosuccinimide in a solvent in the presence of a radical initiator.Type: GrantFiled: August 17, 2000Date of Patent: January 14, 2003Assignee: Shionogi & Co., Ltd.Inventors: Masaaki Uenaka, Masahiko Nagai, Naotake Kobayashi
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Patent number: 5760244Abstract: A process for the preparation of 3-isoxazolecarboxlic acid which is an intermediate for prepearing useful compounds is provided, said process being characterized in that a compound of formula (I) is reacted with hydroxylamine to obtain a compound of formula (II), and the compound thus obtained is treated with an alkali: ##STR1## wherein R.sup.1 is a lower alkyl, R.sup.2 is a carboxy protecting group, X is a halogen atom, and Y is a hydrogen atom, or X and Y together may form a single bond.Type: GrantFiled: July 28, 1997Date of Patent: June 2, 1998Assignee: Shionogi & Co., Ltd.Inventors: Susumu Takada, Nobuo Chomei, Masaaki Uenaka
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Patent number: 5696271Abstract: A process for the preparation of 3-isoxazolecarboxlic acid which is an intermediate for prepearing useful compounds is provided, said process being characterized in that a compound of formula (I) is reacted with hydroxylamine to obtain a compound of formula (II), and the compound thus obtained is treated with an alkali: ##STR1## wherein R.sup.1 is a lower alkyl, R.sup.2 is a carboxy protecting group, X is a halogen atom, and Y is a hydrogen atom, or X and Y together may form a single bond.Type: GrantFiled: August 7, 1996Date of Patent: December 9, 1997Assignee: Shionogi & Co., Ltd.Inventors: Susumu Takada, Nobuo Chomei, Masaaki Uenaka
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Patent number: 5214202Abstract: This invention relates to a synthesis method favorable for the industrial production of a benzoic acid derivative having a retinoid activity of the general formula: ##STR1## wherein the derivative can be obtained by a simple procedure in safety with high yield.Specifically, this invention relates to a synthesis method characterized in that only one vessel is needed for several reactions in the different steps of subjecting acetanilide as a starting material, which is readily available and safe to handle, to Friedel-Crafts reaction with 2,5-dimethyl-2,5-dichlorohexane; subjecting the thus obtained compound to acyl exchange reaction with monomethyl ester terephthalic chloride, followed by hydrolysis; and recrystallizing from a mixture of methanol and water.Moreover, the crystals in novel form obtained by the synthesis method of this invention are suitable for formulation, because the amount of solvents remaining therein after recrystallization is small and the grain size thereof is uniform.Type: GrantFiled: November 6, 1991Date of Patent: May 25, 1993Assignee: Shionogi & Co., Ltd.Inventors: Yoshinori Hamada, Isamu Yamada, Masaaki Uenaka, Teruo Sakata