Abstract: Disclosed is a method for total synthesis of CTX1B, which is developed for the synthesis of a ciguatoxin analogue such as CTX3C and enables the more efficient application of an established reaction to the total synthesis of CTC1B. More specifically, disclosed is a method for total synthesis of CTX1B comprising; an O.S-acetal formation for synthesizing a novel compound (3); a radical cyclization reaction for constructing a 9-membered ring formation reaction including a novel compound (6) through a novel compound (8) and yielding a compound (D); and a deprotection for yielding CTX1B. Also disclosed are novel compounds (1) to (8) which are particularly useful for synthesis of CTX1B and can be used for the synthesis of a ciguatoxin analogue.

Abstract: Disclosed is a method for total synthesis of CTX1B, which is developed for the synthesis of a ciguatoxin analogue such as CTX3C and enables the more efficient application of an established reaction to the total synthesis of CTC1B. More specifically, disclosed is a method for total synthesis of CTX1B comprising; an 0.5-acetal formation for synthesizing a novel compound (3); a radical cyclization reaction for constructing a 9-membered ring formation reaction including a novel compound (6) through a novel compound (8) and yielding a compound (D); and a deprotection for yielding CTX1B. Also disclosed are novel compounds (1) to (8) which are particularly useful for synthesis of CTX1B and can be used for the synthesis of a ciguatoxin analogue.

Abstract: A sandwich immunoassay kit for detecting ciguatoxins based on a combination of two anti-ciguatoxin CTX3C monoclonal antibodies produced by hybridomas, 3D11 (deposited at IPOD, AIST under accession number FMRM PB-8293) and 10C9 (FMRM PB-8292). In particular, one of the antibodies is labeled and each of them binds specifically to a different site of ciguatoxin CTX3C.

Abstract: A sandwich immunoassay kit for detecting ciguatoxins based on a combination of two anti-ciguatoxin CTX3C monoclonal antibodies produced by hybridomas, 3D11 (deposited at IPOD, AIST under accession number FMRM PB-8293) and 10C9 (FMRM PB-8292). In particular, one of the antibodies is labeled and each of them binds specifically to a different site of ciguatoxin CTX3C.

Abstract: A novel method for synthesis of a novel NAP-protected ciguatoxin class precursor represented by following compound 8, and an intermediate useful in the novel method synthesizing the precursor, and a novel method of total synthesis of CTX3C class via the compound 8.

Abstract: The present invention offers the monoclonal antibodies that have a high specificity to ciguatoxins, which are the causative poisons of the ciguatera poisoning. The monoclonal antibodies were produced using synthetic hapten conjugates as artificial antigens, which were prepared by the conjugation of a synthesized hapten consisting of the IJKLM-ring fragment of ciguatoxins with proteins such as KLH, BSA, etc. The monoclonal antibodies show a specific reactivity to ciguatoxins, but little or almost no reactivity to other marine polyether toxins such as the okadaic acid, etc.

Abstract: Corrosion resistant material is used for lead wires of the thermistor, and an exposed portion of electrodes of the thermistor and a portion surrounding a weld portion of the lead wires are coated with corrosion resistant material. Since the lead wires themselves are made of corrosion resistant material, no corrosion occurs in the welding portion and a cut working portion. Further, the lead wires and the exposed portion of the electrodes are coated with corrosion resistant material. Thereby an electronic device having extremely high corrosion resistivity and hence high durability and reliability is produced, with the result that the electronic device can be used for a long period without corrosion under the heavily corrosive environment, such as sulfur dioxide gas atmosphere.

Abstract: A microwave oven has only a microwave sensor or both microwave sensor and temperature sensor. The microwave sensor has a wave absorber to generate heat through absorption of microwave energy and a thermistor to detect temperature of this wave absorber. The temperature sensor has a thermistor to detect the ambient temperature around the wave absorber. A controller determines a value of microwave power on the basis of the output of the microwave sensor or each output of the microwave sensor and temperature sensor. The microwave oven can accurately detect microwave power without being influenced by variation of ambient temperature around the microwave sensor.

Abstract: A lead type chip capacitor which is disclosed herein comprises a capacitor chip having a lead terminal bonded thereto through a joining or bonding layer made of a highly melting metal paste. The lead type chip capacitor is produced by bonding at least one internal electrode in a capacitor chip with a lead terminal by a metal paste, drying them at a temperature in a range of 100.degree. to 200.degree. C., and firing the resulting capacitor chip with the lead terminal bonded thereto at a temperature in a range of 500.degree. to 900.degree. C. in the air or in a nitrogen atmosphere.

Abstract: A multilayered ceramic capacitor includes glass melted layers and adhering layers containing conductive patters in which the combination of two or more different species of dielectric materials are used for ceramic layers in the stack of the multilayered capacitor.

Abstract: A multi-layered ceramic capacitor characterized by a structure containing glass material layers imposed between adjacent ceramic layers and conductive layers which sandwich the glass material therebetween. The conductive electrode layers and/or glass material layers bind the thin ceramic film pieces during firing at lower temperatures resulting in a strong bonded capacitor having numerous electrical applications.